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anti-Human FURIN Antikörper:
anti-Mouse (Murine) FURIN Antikörper:
anti-Rat (Rattus) FURIN Antikörper:
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Cow (Bovine) Polyclonal FURIN Primary Antibody für ELISA, WB - ABIN2473713
Bray: Notch signalling: a simple pathway becomes complex. in Nature reviews. Molecular cell biology 2006
Human Polyclonal FURIN Primary Antibody für ELISA, WB - ABIN4312814
Jin, Wang, Millar, Quertermous, Rothblat, Glick, Rader: Hepatic proprotein convertases modulate HDL metabolism. in Cell metabolism 2007
Silencing furin genes reduced the survival of M. marinum-infected zebrafish embryos. A mycobacterial infection upregulated furinA in adult zebrafish.
Genetic analysis of fin development in zebrafish identifies furin as potential novel fraser syndrome disease genes
furin genes may function partially redundantly to activate Endothelin1 signaling in craniofacial patterning
the furin inhibitor dec-RVKR-CMK (zeige CXCL9 Antikörper) blocked entry of MERS-CoV harboring an S protein (zeige CDSN Antikörper) lacking furin cleavage sites; it even blocked entry into furin-deficient LoVo cells. In addition, dec-RVKR-CMK (zeige CXCL9 Antikörper) inhibited not only the enzymatic activity of furin but also those of cathepsin L (zeige CTSL1 Antikörper), cathepsin B (zeige CTSB Antikörper), trypsin, papain, and TMPRSS2 (zeige TMPRSS2 Antikörper).
Using protein X-ray crystallography, this study investigated the extended substrate binding site of furin in complex with three peptide-derived inhibitors at up to 1.9 A resolution.
In squamous cell carcinoma of the cervix (SCCC), higher levels of MMP-14 (zeige MMP14 Antikörper) expression were established in tumor cells, as evidenced by IHC (+3) and RT-PCR.Furin activity in the tumor was much higher than that in normal tissues. The expression of TIMP-2 (zeige TIMP2 Antikörper) mRNA was sufficiently obvious in both the tumor and normal tissues to the bottom of the uterine cavity.
these findings identify furin as an important factor for aRMS progression and survival. Thus, we propose furin as a novel therapeutic target for treatment of aRMS.
Novel protein crystallographic structures of the prototypical PC family member furin in different functional states were determined to 1.8-2.0 A.
findings uncover a role of ERK1 (zeige MAPK3 Antikörper) in the regulation of furin activity by supporting a self-sustaining loop for high TGF-beta (zeige TGFB1 Antikörper) activity in glioma-initiating cells.
Divers studies have confirmed the expression of furin in a large spectrum of cancers. Functional studies modulating its activity uncovered its importance for the processing of many cancer-related substrates and strongly indicate that high furin activity promotes the malignant phenotype of cancer cells. [review]
Furin plays an important role in the malignant phenotype of rhabdomyosarcoma cells by activating proteins involved in tumor growth, vascularization, metastasis and invasion.
Furin promotes epithelial-mesenchymal transition in pancreatic cancer cells probably via Hippo-YAP (zeige YAP1 Antikörper) pathway and may be a potential target for anti-pancreatic cancer.
Results suggest that (pro)renin receptor (zeige ATP6AP2 Antikörper) (s(P)RR (zeige ATP6AP2 Antikörper)) is generated by sequential processing by site-1 protease (S1P (zeige MBTPS1 Antikörper)) and furin protein.
The developmental arrest of early secondary follicles following furin disruption might be rooted in the loss of the mature form of ADAMTS1 (zeige ADAMTS1 Antikörper) and compromised proliferation of granulosa cells in mutant mice.
FURIN has an anti-inflammatory function in LysM+ myeloid cells in vivo.
The proprotein convertase furin is responsible for pro-OCN maturation in vitro and in vivo.
Studied the impact of Furin inhibition on the development and progression of hepatocellular carcinoma.
PC7 (zeige PCSK7 Antikörper) and the related proteases Furin and Pace4 (zeige PCSK6 Antikörper) regulate E-cadherin (zeige CDH1 Antikörper) function during blastocyst formation.
work confirms the hypothesis that the TCR-regulated protease FURIN plays an important role in T cell activation and that it can specifically modulate TCR-activated transactivation
the role of serpinB8 (zeige SERPINB8 Antikörper)/furin in obesity-associated chronic inflammation
Furin has a role as the primary in vivo convertase of ANGPTL3 (zeige ANGPTL3 Antikörper) and endothelial lipase (zeige LIPG Antikörper) in hepatocytes
overexpression of PCs, furin and PC5 (zeige PCSK5 Antikörper), but not PC7 (zeige PCSK7 Antikörper), which are all expressed in SMC (zeige DYM Antikörper), increase PKGI (zeige PRKG1 Antikörper) cleavage in a dose-dependent manner
Point mutation of the furin cleavage site at the S2' position of the S protein enables the virus to infect cultured cells independently of trypsin.
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene.
furin (paired basic amino acid cleaving enzyme)
, furin A
, furin B
, FES upstream region
, dibasic processing enzyme
, dibasic-processing enzyme
, furin, membrane associated receptor protein
, paired basic amino acid residue-cleaving enzyme
, proprotein convertase subtilisin/kexin type 3
, paired basic amino acid residue cleaving enzyme
, prohormone convertase 3
, subtilisin pro-protein processing enzyme
, paired basic amino acid cleaving enzyme
, trans Golgi network protease furin
, Paired basic amino acid cleaving enzyme (furin)
, Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein)
, proprotein convertase subtilisin/kexin type3