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we identified F-box and WD repeat domain-containing 7 (FBXW7) protein as a direct functional target of miR (zeige MLXIP Proteine)-25 in esophageal squamous cell carcinoma (ESCC). In conclusion, the present study supports the potential of miR (zeige MLXIP Proteine)-25 as a prognostic predictor with its high expression in cancer tissues and its association with tumor progression by targeting FBXW7 in ESCC
FBXW7 was significantly downregulated in renal cell carcinoma (zeige MOK Proteine) cell lines. Upregulation of FBXW7 in 786-O and ACHN (zeige LARP6 Proteine) cell lines significantly inhibited cell migration, invasion and EMT (zeige ITK Proteine).
FBXW7 missense mutation is associated with metastatic colorectal adenocarcinoma.
miR (zeige MLXIP Proteine)-92b-3p inhibition prevented colorectal cancer proliferation, invasion, and migration by upregulating FBXW7, which might suggest the potential role of miR (zeige MLXIP Proteine)-92b-3p in colorectal carcinogenesis and metastasis.
FBXW7 is markedly downregulated in the liver of obese subjects. A functional low-frequency human FBXW7 coding variant ( (zeige AHSG Proteine)p.Ala204Thr) is associated with elevated blood glucose and T2DM risk in a Chinese population. Mechanistically, FBXW7 directly binds to hepatokine fetuin-A to induce its ubiquitination and subsequent proteasomal degradation, comprising an important mechanism maintaining glucose homeostasis.
Our findings suggest FBW7 mutational status and Mcl-1 (zeige MCL1 Proteine) stability as key determinants of response to Hsp90 (zeige HSP90 Proteine) inhibitors, which provides a rationale for using FBW7 genotype for potential patient stratification, and for drug combinations with Hsp90 (zeige HSP90 Proteine) inhibitors that can effectively overcome Mcl-1 (zeige MCL1 Proteine)-mediated resistance.
a cancer stem cell-specific FBXW7-regulatory mechanism is strongly associated with resistance to chemotherapeutic agents.
FBW7 promoted gemcitabine sensitivity via upregulation of equilibrative nucleoside transporter 1 (ENT1 (zeige SLC29A1 Proteine)) at the protein level rather than the transcriptional level.
FBW7 overexpression downregulated Aurora B (zeige AURKB Proteine), Mcl1 (zeige MCL1 Proteine) and Notch1 (zeige NOTCH1 Proteine) levels.
FBXW7 was a downstream target of miR (zeige MLXIP Proteine)-367 and CASC2 prohibited epithelial-to-mesenchymal transition progression and subsequently exerted its anti-metastatic effects via CASC2/miR (zeige MLXIP Proteine)-367/FBXW7 axis in hepatocellular carcinoma cells.
FBXW7 is markedly downregulated in the liver of obese mice. Mechanistically, FBXW7 directly binds to hepatokine fetuin-A (zeige AHSG Proteine) to induce its ubiquitination and subsequent proteasomal degradation, comprising an important mechanism maintaining glucose homeostasis.
the regulatory crosstalk between KLF5 (zeige KLF5 Proteine), miR (zeige MLXIP Proteine)-29a, and Fbw7/CDC4 cooperatively promotes atherosclerotic development
found that Fbw7 loss caused activation of NF-kappaB (zeige NFKB1 Proteine) signaling. Thus, FBW7 plays a protective role in acute intestinal inflammation by modulating the inflammatory response of NF-kappaB (zeige NFKB1 Proteine) pathway.
EglN2 might act as an FBW7 ubiquitin ligase substrate contributing to the progression of triple negative breast cancer.
These findings highlight the molecular basis of Hajdu-Cheney syndrome (HCS (zeige HLCS Proteine)) pathogenesis and provide clinical insights into potential targeted therapeutic strategies for skeletal disorders associated with the aberrant FBW7/NOTCH2 (zeige NOTCH2 Proteine) pathway as observed in patients with HCS (zeige HLCS Proteine).
The findings reveal a PLK1-Fbw7-Myc (zeige MYC Proteine) signaling circuit that underlies tumorigenesis and validate PLK1 inhibitors, alone or with Bcl2 (zeige BCL2 Proteine) antagonists, as potential effective therapeutics for MYC (zeige MYC Proteine)-overexpressing cancers.
Fbxw7 suppresses KrasG12D-induced pancreatic tumorigenesis via a Yap (zeige YAP1 Proteine)-dependent mechanism.
Study identifies a REV-ERBalpha (zeige NR1D1 Proteine) post-translational regulatory circuit in which cyclin-dependent kinase 1 (CDK1 (zeige CDK1 Proteine)) phosphorylation of REV-ERBalpha (zeige NR1D1 Proteine) is recognized by the F-box protein (zeige FBXO30 Proteine), FBXW7alpha, to direct REV-ERBalpha (zeige NR1D1 Proteine) degradation via the proteasome. Disruption of this CDK1 (zeige CDK1 Proteine)-FBXW7-mediated REV-ERBalpha (zeige NR1D1 Proteine) degradation pathway in mouse liver alters circadian rhythmicity, in particular amplitude, and whole-body lipid/glucose home...
Gene expression profiling reveals transcriptional regulation by Fbxw7/mTOR (zeige FRAP1 Proteine) pathway in radiation-induced mouse thymic lymphomas.
Prion (zeige PRNP Proteine) infection induced the expression of FBXW7 in brain.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
F-box and WD-40 domain protein 7
, F-box/WD repeat-containing protein 7
, F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)
, F-box protein FBW7
, F-box protein FBX30
, F-box protein SEL-10
, homolog of C elegans sel-10
, F-box and WD-40 domain protein 7, archipelago homolog
, F-box and WD-40 domain-containing protein 7
, F-box protein Fbxw6
, F-box-WD40 repeat protein 6
, f-box only protein 30