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anti-Rat (Rattus) FBXW7 Antikörper:
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Human Monoclonal FBXW7 Primary Antibody für IHC (p), ELISA - ABIN527479
Enchev, Scott, da Fonseca, Schreiber, Monda, Schulman, Peter, Morris: Structural basis for a reciprocal regulation between SCF and CSN. in Cell reports 2012
Show all 5 Pubmed References
Human Polyclonal FBXW7 Primary Antibody für ICC, IF - ABIN4892424
Lu, Pfeffer: Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression. in The Journal of cell biology 2013
Show all 4 Pubmed References
Human Polyclonal FBXW7 Primary Antibody für IP - ABIN257813
Bengoechea-Alonso, Ericsson: The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation. in Proceedings of the National Academy of Sciences of the United States of America 2010
Show all 2 Pubmed References
Human Polyclonal FBXW7 Primary Antibody für IF (p), IHC (p) - ABIN1386103
Wang, Yang, Liu, Huang, Wang, Chen, Chen: RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53-Fbxw7 pathway. in Biochemical and biophysical research communications 2015
Human Polyclonal FBXW7 Primary Antibody für IF, WB - ABIN527477
Maskey, Marlin, Kim, Kim, Ong, Li, Tsiokas: Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length. in The EMBO journal 2015
Cow (Bovine) Polyclonal FBXW7 Primary Antibody für IHC, WB - ABIN2780093
Huang, Ma, Li, Yu, Zhang, Wei, Jin, Xu, Gao, Huang: NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression. in Oncotarget 2014
Cow (Bovine) Polyclonal FBXW7 Primary Antibody für IHC, WB - ABIN2782955
Gong, Zack, Morris, Lin, Hukkelhoven, Raheja, Tan, Turcan, Veeriah, Meng, Viale, Schumacher, Palmedo, Beroukhim, Chan: Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins. in Nature genetics 2014
Human Monoclonal FBXW7 Primary Antibody für IHC, WB - ABIN2674168
Wang, Zhang, Zhou, Sun, Zheng, Lu, Gao, Yang, Zhang, Tao, Dou: Fbxw7 regulates hepatocellular carcinoma migration and invasion via Notch1 signaling pathway. in International journal of oncology 2015
Fbxw7 haploinsufficiency increased the risk of gastric carcinogenesis induced by MNU, which is associated with the accumulation of DNA damage as well as c-Myc (zeige MYC Antikörper) oncoprotein.
EglN2 might act as an FBW7 ubiquitin ligase substrate contributing to the progression of triple negative breast cancer.
FAM83D (zeige FAM83D Antikörper) knockdown up-regulated the protein expression level of F-box and WD repeat domain-containing 7 (FBXW7), but diminished the Notch1 (zeige NOTCH1 Antikörper) protein expression level.
Thus, our study uncovers a novel regulatory mechanism underlying which KLF10 (zeige KLF10 Antikörper) stability and its biological function are mediated by FBW7.
Results found it showed reduced expression in diffuse large B-cell lymphoma (DLBCL), which was associated with a poor outcome. Fbw7 expression promotes apoptosis in DLBCL cell lines. Furthermore, the study demonstrated that Fbw7 targets Stat3 (zeige STAT3 Antikörper) and especially activated Stat3 (zeige STAT3 Antikörper) for ubiquitylation to regulate its stability.
Data suggest that FBXW7, MCL1 (zeige MCL1 Antikörper) and PLK1 (zeige PLK1 Antikörper) may be relevant predictive markers of tumor progression and response to paclitaxel treatment.
FBW7 serves as a negative regulator of glucose metabolism through regulation of the c-Myc (zeige MYC Antikörper)/TXNIP (zeige TXNIP Antikörper) axis in pancreatic cancer.
increased expression of activated NOTCH1 (zeige NOTCH1 Antikörper) was found in NOTCH1 (zeige NOTCH1 Antikörper)/FBXW7 hotspot exon-mutated cases. Study suggests that NOTCH1 (zeige NOTCH1 Antikörper)/FBXW7 hotspot-mutated T-ALL cases had better response to ALL BFM-95 protocol.
Study identify SCF (zeige KITLG Antikörper)-FBW7 as a ubiquitin E3 ligase that regulates the cellular FAAP20 levels and Fanconi anemia (zeige PALB2 Antikörper) (FA) pathway. Deregulation of the GSK3beta- and FBW7-dependent FAAP20 degradation leads to a defect in the FA pathway, establishing a direct link between FBW7 and DNA repair.
HRAS (zeige HRAS Antikörper) mutations were more common in epithelial-myoepithelial carcinomas (EMCAs) with intact PLAG1 (zeige PLAG1 Antikörper) and HMGA2. Most EMCAs arose ex pleomorphic adenoma (PA)and the genetic profile of EMCA varies with the absence or presence of preexisting PA and its cytogenetic signature. Progression to higher grade EMCA with intact PLAG1 (zeige PLAG1 Antikörper) and HMGA2 correlates with the presence of TP53 (zeige TP53 Antikörper), FBXW7 mutations, or SMARCB1 (zeige SMARCB1 Antikörper) deletion.
These findings highlight the molecular basis of Hajdu-Cheney syndrome (HCS (zeige HLCS Antikörper)) pathogenesis and provide clinical insights into potential targeted therapeutic strategies for skeletal disorders associated with the aberrant FBW7/NOTCH2 (zeige NOTCH2 Antikörper) pathway as observed in patients with HCS (zeige HLCS Antikörper).
The findings reveal a PLK1 (zeige PLK1 Antikörper)-Fbw7-Myc (zeige MYC Antikörper) signaling circuit that underlies tumorigenesis and validate PLK1 (zeige PLK1 Antikörper) inhibitors, alone or with Bcl2 (zeige BCL2 Antikörper) antagonists, as potential effective therapeutics for MYC (zeige MYC Antikörper)-overexpressing cancers.
Fbxw7 suppresses KrasG12D-induced pancreatic tumorigenesis via a Yap (zeige YAP1 Antikörper)-dependent mechanism.
Study identifies a REV-ERBalpha (zeige NR1D1 Antikörper) post-translational regulatory circuit in which cyclin-dependent kinase 1 (CDK1 (zeige CDK1 Antikörper)) phosphorylation of REV-ERBalpha (zeige NR1D1 Antikörper) is recognized by the F-box protein (zeige FBXO30 Antikörper), FBXW7alpha, to direct REV-ERBalpha (zeige NR1D1 Antikörper) degradation via the proteasome. Disruption of this CDK1 (zeige CDK1 Antikörper)-FBXW7-mediated REV-ERBalpha (zeige NR1D1 Antikörper) degradation pathway in mouse liver alters circadian rhythmicity, in particular amplitude, and whole-body lipid/glucose home...
Gene expression profiling reveals transcriptional regulation by Fbxw7/mTOR (zeige FRAP1 Antikörper) pathway in radiation-induced mouse thymic lymphomas.
Prion (zeige PRNP Antikörper) infection induced the expression of FBXW7 in brain.
FBXW7 facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4 (zeige XRCC4 Antikörper) in tumor cells.
data demonstrate that Fbw7alpha negatively regulates osteogenesis by targeting Runx2 for ubiquitin-mediated degradation in a GSK3beta-dependent manner
In mice, an unusually direct antagonism between an E3 ligase and a deubiquitinase, Fbw7 and Usp28 (zeige USP28 Antikörper), modulate intestinal homeostasis and cancer.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
F-box and WD-40 domain protein 7
, F-box/WD repeat-containing protein 7
, F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)
, F-box protein FBW7
, F-box protein FBX30
, F-box protein SEL-10
, homolog of C elegans sel-10
, F-box and WD-40 domain protein 7, archipelago homolog
, F-box and WD-40 domain-containing protein 7
, F-box protein Fbxw6
, F-box-WD40 repeat protein 6
, f-box only protein 30