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Human TRAF6 Protein expressed in Wheat germ - ABIN1323514
Nakada, Tai, Panier, Al-Hakim, Iemura, Juang, ODonnell, Kumakubo, Munro, Sicheri, Gingras, Natsume, Suda, Durocher: Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. in Nature 2010
Human TRAF6 Protein expressed in HEK-293 Cells - ABIN2734115
Tikhanovich, Kuravi, Artigues, Villar, Dorko, Nawabi, Roberts, Weinman: Dynamic Arginine Methylation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 Regulates Toll-like Receptor Signaling. in The Journal of biological chemistry 2015
we found that reactive oxygen species-induced autophagy acts as a negative feedback regulator of JNK (zeige MAPK8 Proteine) activity by dissociating Atg9 (zeige ATG9A Proteine)/mAtg9 (zeige ATG9A Proteine) from dTRAF2/TRAF6 in Drosophila.
null mutant of DTRAF2 showed immune deficiencies in which NF-kappaB nuclear translocation and antimicrobial gene transcription against microbial infection were severely impaired
TRAF6 coiled-coil oligomerization domain primes its interaction with Ubc13 (zeige UBE2N Proteine)/Ub~Ubc13 (zeige UBE2N Proteine) to confer processivity. Long polyUb chain assembly requires coiled-coil domain of TRAF6
TRAF6 is a key promoter of ischemic signaling cascades and neuronal death after cerebral ischemia/reperfusion injury. TRAF6 upregulation binds and ubiquitinates Rac1 directly, which promotes neuron death through neuroinflammation and neuro-oxidative signals.
Data provide a novel association between WDFY3 and the RANKL (zeige TNFSF11 Proteine)-induced osteoclastogenesis pathway via the modulation of TRAF6.
this study shows that TRAF6 is necessary for the nontranscriptional priming of NLRP3 (zeige NLRP3 Proteine) inflammasome by TLR/IL-1R derived signals
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (zeige TRAF1 Proteine)/NF-kappaB (zeige NFKB1 Proteine)-regulated apoptosis and the p53 (zeige TP53 Proteine)/PCNA (zeige PCNA Proteine)- and ATM (zeige ATM Proteine)/ATR-Chk1 (zeige CHEK1 Proteine)/2-controlled DNA-damage response pathways.
TRAF6 prevents the mitochondrial translocation of p53 (zeige TP53 Proteine) and spontaneous apoptosis by promoting lysine63-linked ubiquitination of p53 (zeige TP53 Proteine) in cytosol.
TRAF6 mediates lysine-63 ubiquitination within the SH2 domain of STAT3 (zeige STAT3 Proteine), which is an essential step for STAT3 (zeige STAT3 Proteine) membrane recruitment and phosphorylation in response to S Typhimurium infection; results reveal a strategy in which S Typhimurium T3SS effectors broaden their functions through the activation of host proteins in a ubiquitination-dependent manner to manipulate host cells into becoming a Salmonella-friendly zone
this study shows that an interaction of TRAF6 with cullin-5 (zeige CUL5 Proteine) promotes TRAF6 polyubiquitination and lipopolysaccharide signaling
Consistent with cellular studies, icaritin downregulated TRAF6 and NFATc1 protein expression in CD11b(+) /Gr-1(-/low) osteoclast precursors
Data (including data from studies using knockout mice) suggest that RANKL (zeige TNFSF11 Proteine) enhances TNF (zeige TNF Proteine)-induced osteoclast formation from precursor spleen cells and enhances bone resorption independently of Traf6 by degrading Traf3 (zeige TRAF3 Proteine), a known inhibitor of osteoclastogenesis. (RANKL (zeige TNFSF11 Proteine) = osteoclast differentiation factor (zeige TNFSF11 Proteine); TNF (zeige TNF Proteine) = tumor necrosis factor (zeige TNF Proteine); Traf (zeige TRAF1 Proteine) = TNF (zeige TNF Proteine) receptor-associated factor)
we have now analyzed the in vivo function of Traf6 in the innate immune response without interference of adaptive immunity
Full-length traf6 was functionally characterized.
Epigallocatechin-3-gallate is a novel E3 ubiquitin ligase (zeige MUL1 Proteine) inhibitor that could be used to target TRAF6 activity in melanoma cells, inhibiting cell proliferation/migration.
Results identified TRAF6 as a direct target of miR (zeige MLXIP Proteine)-429, and its downregulation partially attenuates the effect of miR (zeige MLXIP Proteine)-429 in promoting hepatocellular carcinoma cell proliferation and motility.
Compared with normal chondrocytes, the expression of miR (zeige MLXIP Proteine)-146a decreased, while the mRNA and protein expressions of TRAF6 and NF-kappaB (zeige NFKB1 Proteine) increased in osteoarthritis chondrocytes.
We report two siblings with SCID (zeige PRKDC Proteine) and an atypical phenotype of osteopetrosis (OP (zeige CSF1 Proteine)). A biallelic microdeletion encompassing the 5' region of TRAF6, RAG1 (zeige RAG1 Proteine) and RAG2 (zeige RAG2 Proteine) genes was identified. TRAF6, a tumor necrosis factor (zeige TNF Proteine) receptor-associated family member, plays an important role in T cell signaling and in RANKL (zeige TNFSF11 Proteine)-dependent osteoclast differentiation and activation but its role in human OP has not been previously reported
miR (zeige MLXIP Proteine)-146a improves intestine epithelial cells survival under ischemia and I/R injury through inhibition TLR4 (zeige TLR4 Proteine), TRAF6, and p-IkappaBalpha (zeige NFKBIA Proteine), subsequently leading to decreased NF-kappaB (zeige NFKB1 Proteine) p65 (zeige GORASP1 Proteine) nuclear translocation.
Taken together, these results define a novel role for miR (zeige MLXIP Proteine)-146a as a negative regulator of dengue virus-induced autophagy and identify TRAF6 as a key target of this microRNA in modulating the dengue virus-autophagy interaction.
These data define that YOD1 (zeige YOD1 Proteine) antagonizes TRAF6/p62 (zeige GTF2H1 Proteine)-dependent IL-1 (zeige IL1A Proteine) signaling to NF-kappaB (zeige NFKB1 Proteine).
high expression of TRAF6 is significant for esophageal cancer progression, and TRAF6 indicates poor prognosis in esophageal cancer patients.
CRBN (zeige CRBN Proteine) negatively regulates TLR4 (zeige TLR4 Proteine) signaling via attenuation of TRAF6 and TAB2 (zeige TAB2 Proteine) ubiquitination.
the polymorphisms in TLR-MyD88 (zeige MYD88 Proteine)-NF-kappaB (zeige NFKB1 Proteine) signaling pathway confer genetic susceptibility to Type 2 diabetes mellitus and diabetic nephropathy.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.
TNF receptor-associated factor 6-B
, E3 ubiquitin-protein ligase TRAF6
, TNF-receptor-associated factor 2
, TNF receptor-associated factor 6
, TNF receptor-associated factor 6-like
, RING finger protein 85
, interleukin-1 signal transducer
, TNF-receptor associated factor 6