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Human TNFSF13B Protein expressed in Escherichia coli (E. coli) - ABIN1344400
Bossen, Cachero, Tardivel, Ingold, Willen, Dobles, Scott, Maquelin, Belnoue, Siegrist, Chevrier, Acha-Orbea, Leung, Mackay, Tschopp, Schneider: TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts. in Blood 2008
Show all 2 Pubmed References
Human TNFSF13B Protein expressed in HEK-293 Cells - ABIN1344293
Huard, Tran, Benkhoucha, Manzin-Lorenzi, Santiago-Raber: Selective APRIL blockade delays systemic lupus erythematosus in mouse. in PLoS ONE 2012
Human TNFSF13B Protein expressed in Escherichia coli (E. coli) - ABIN413043
Kern, Cornuel, Billard, Tang, Rouillard, Stenou, Defrance, Ajchenbaum-Cymbalista, Simonin, Feldblum, Kolb: Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway. in Blood 2004
Equine adipose-derived stem cell (ASC (zeige PYCARD Proteine)) expresses BAFF (TNFSF13B) and its receptors, which may be associated with the differentiation process of ASC (zeige PYCARD Proteine) towards adipocyte.
BAFF-R (zeige TNFRSF13C Proteine) was consistently expressed on B cells infected by HCMV. Enhancement of BAFF/BAFF-R (zeige TNFRSF13C Proteine) signaling decreased the apoptosis rate and extended the survival of B cells.
soluble BCMA (zeige TNFRSF17 Proteine) sequesters circulating BAFF, thereby preventing it from performing its signaling to stimulate normal B-cell and plasma cell development, resulting in reduced polyclonal antibody levels in multiple myeloma patients.
results showed that serum BAFF in nasal type, extranodal NK/T cell lymphoma patients was significantly higher than that in control group and negatively correlated with patients' survival.
BAFF has a role in inducing IL35 (zeige EBI3 Proteine) production by regulatory B cells in lupus
Inhibition of ADAM10 (zeige ADAM10 Proteine) augments BAFF-dependent survival of primary human B cells, whereas inhibition of ADAM17 (zeige ADAM17 Proteine) increases BAFFR (zeige TNFRSF13C Proteine) expression levels
Data presented show that B-cell activating factor (BAFF) plays a central role in the induction and maintenance of cigarette smoke-induced pulmonary antinuclear antibodies and suggest a therapeutic potential for BAFF blockade in limiting autoimmune processes associated with smoking.
Among the BAFF receptors in a cohort of rheumatoid arthritis (RA) patients, the AA have shown, by fluorescence activated cell sorter (FACS) analysis of median fluorescence intensity (MFI), that transmembrane activator and calcium-modulating cyclophilin ligand (zeige CAMLG Proteine) interactor (TACI (zeige TNFRSF13B Proteine)) and B cell maturation antigen (BCMA (zeige TNFRSF17 Proteine)) do not change
The BAFF promoter increased in response to TNF-alpha (zeige TNF Proteine) treatment or overexpression of HIF-1alpha (zeige HIF1A Proteine). However, TNF-alpha (zeige TNF Proteine)-induced BAFF expression and promoter activity decreased after treatment with the ERK (zeige EPHB2 Proteine) inhibitor PD98059.
This study indicates that orbital fibroblasts from Graves' orbitopathy can express BAFF and mediate the intraorbital survival of B cells via BAFF mechanism.
Inhibition of B cell plasmablast differentiation by reduction of Aiolos (zeige IKZF3 Proteine) and Ikaros (zeige IKZF1 Proteine) may have utility in the treatment of systemic lupus erythematosus , where elevated levels of BAFF and Aiolos (zeige IKZF3 Proteine) may prime CD27 (zeige CD27 Proteine)(+) memory and double negative memory-like B cells to become Ab-producing plasmablasts in the presence of BAFF and proinflammatory cytokines.
This study suggests that BAFF selects IL-10 (zeige IL10 Proteine)(-)B cells over IL-10 (zeige IL10 Proteine)(+) regulatory B cells via BAFF receptors in inflammatory responses
BAFF plays a previously unappreciated role in lupus nephritis by inducing renal tertiary lymphoid structures and regulating the position of T cells within the glomeruli.
this study shows that BAFF overexpression reduces hypercholesterolemia and atherosclerosis in hyperlipidemic mice via TACI (zeige TNFRSF13B Proteine)-dependent B cell activation (zeige BLNK Proteine)
B cell-activating factor (BAFF) upregulates CD28 (zeige CD28 Proteine)/B7 and CD40 (zeige CD40 Proteine)/CD154 (zeige CD40LG Proteine) expression, and promotes the interactions between T and B cells in a BAFF receptor (zeige TNFRSF13C Proteine)-dependent manner.
findings highlight a novel mechanism through which BAFF promotes humoral autoimmunity via direct, TACI (zeige TNFRSF13B Proteine)-dependent activation of transitional B cells
neutrophils secreted a B cell-activating factor that highly accelerated plasma cell generation and antigen-specific antibody production.
The enhanced thermogenic program was confirmed by higher protein levels of UCP1 (zeige UCP1 Proteine) and irisin (zeige FNDC5 Proteine) in female BAFF-/- than in WT mice.
Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF (zeige TNF Proteine)) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.
Increased B-cell activating factor (BAFF) induced B cell differentiation into germinal center (GC) B (zeige NPR2 Proteine) cells within the autoimmune target tissue.
study reports the molecular cloning, expression and bioactivity of the porcine homologue of human BAFF
This study demonstrated expression of BAFF on cultured monocyte-derived dendritic cells, which was further enhanced by interferon-alpha (zeige IFNA Proteine) or interferon-gamma (zeige IFNG Proteine) treatment.
Although BAFF expression is dispensable for B cell development in the bone marrow, it is required for B cell development in gut (zeige GUSB Proteine)-associated lymphoid tissue.
BAFF and its receptors during B-cell activation (zeige BLNK Proteine) and autoantibody production in rabbits derived from selective breeding to develop a reproducible rabbit model of Systemic Lupus Erythematosus, were investigated.
Cloning and expression analysis of B-cell activating factor (BAFF) provide the basis for investigation of its role in regulating rabbit B-lymphocyte (zeige AKAP17A Proteine) development and immune responses.
BAFF was detected in developing appendix of young rabbits by immunohistochemical staining suggesting that BAFF plays a role during the period following birth when rabbit B-cell development is occurring.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
tumor necrosis factor ligand superfamily member 13B
, tumor necrosis factor (ligand) superfamily, member 13b
, B-cell activating factor
, B-lymphocyte stimulator
, TNF- and APOL-related leukocyte expressed ligand 1
, ApoL related ligand TALL-1
, B-cell-activating factor
, Delta4 BAFF
, TNF and ApoL-related leukocyte expressed ligand 1
, TNF homolog that activates apoptosis
, delta BAFF
, dendritic cell-derived TNF-like molecule
, tumor necrosis factor (ligand) superfamily, member 20
, tumor necrosis factor-like protein ZTNF4
, b cell-activating factor
, tumor necrosis factor superfamily member 13b