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anti-Rat (Rattus) TNFRSF11A Antikörper:
anti-Mouse (Murine) TNFRSF11A Antikörper:
anti-Human TNFRSF11A Antikörper:
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Human Monoclonal TNFRSF11A Primary Antibody für CyTOF, FACS - ABIN252472
Fiumara, Snell, Li, Mukhopadhyay, Younes, Gillenwater, Cabanillas, Aggarwal, Younes: Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines. in Blood 2001
Show all 15 Pubmed References
Human Monoclonal TNFRSF11A Primary Antibody für FACS, IHC (p) - ABIN252036
Lee, Kim, Jun, Yoo, Woo, Choi, Lee, Song, Sohn, Park-Min, Ivashkiv, Ji: Direct inhibition of human RANK+ osteoclast precursors identifies a homeostatic function of IL-1beta. in Journal of immunology (Baltimore, Md. : 1950) 2010
Show all 10 Pubmed References
Human Monoclonal TNFRSF11A Primary Antibody für CyTOF, ELISA (Capture) - ABIN4900544
Vernal, Dutzan, Hernández, Chandía, Puente, León, García, Del Valle, Silva, Gamonal: High expression levels of receptor activator of nuclear factor-kappa B ligand associated with human chronic periodontitis are mainly secreted by CD4+ T lymphocytes. in Journal of periodontology 2006
Show all 6 Pubmed References
Human Monoclonal TNFRSF11A Primary Antibody für FACS - ABIN4897927
Riegel, Maurer, Prior, Stegmaier, Heppert, Wagner, Hänsch: Human polymorphonuclear neutrophils express RANK and are activated by its ligand, RANKL. in European journal of immunology 2012
Mouse (Murine) Monoclonal TNFRSF11A Primary Antibody für FACS, IP - ABIN2479562
García-Pérez, Noguera, Hermenegildo, Martínez-Romero, Tarín, Cano: Alterations in the phenotype and function of immune cells in ovariectomy-induced osteopenic mice. in Human reproduction (Oxford, England) 2006
RANKL (zeige TNFSF11 Antikörper)/RANK control progenitor cell expansion and tumorigenesis in inherited breast cancer.
Artesunate inhibits RANKL (zeige TNFSF11 Antikörper)-induced osteoclastogenesis by suppressing the NF-kappaB (zeige NFKB1 Antikörper) signaling pathway.
Data suggest that mutations at position I248 in DE-loop of murine RANKL (zeige TNFSF11 Antikörper) have effects on interaction of RANKL (zeige TNFSF11 Antikörper) with RANK and on subsequent activation of osteoclastogenesis by this hetero-multimer. (RANKL (zeige TNFSF11 Antikörper) = osteoclast differentiation factor (zeige TNFSF11 Antikörper); RANK = tumor necrosis factor (zeige TNF Antikörper) receptor superfamily, member 11a protein)
The persistence of bone erosion and synovial osteoclasts in Rank-deficient mice, and the ability of TNF (zeige TNF Antikörper)/IL-6 (zeige IL6 Antikörper) to induce osteoclastogenesis, suggest that more than one cytokine pathway exists to generate these bone-resorbing cells in inflamed joints.
Muscle RANK deletion had no significant effects on the sham or denervated slow-twitch soleus muscles. These data identify a novel role for RANK as a key regulator of Ca(2 (zeige CA2 Antikörper)+)storage and SERCA (zeige ATP2A3 Antikörper) activity, ultimately affecting denervated skeletal muscle function.
present study shows that ginsenoside Rg3 protects against LPS (zeige TLR4 Antikörper)-induced acute lung injury through inactivating the NF-kappaB (zeige NFKB1 Antikörper) signaling
In palmatine-treated mice, RANKL (zeige TNFSF11 Antikörper) and OPG (zeige TNFSF11 Antikörper) expression decreased. In the culture supernatant of MC3T3-E1 cells, RANKL (zeige TNFSF11 Antikörper) and OPG (zeige TNFSF11 Antikörper) levels were significantly reduced by palmatine addition.
Results show that moderate increases in affinity for RANK lead to a substantial augmentation of osteoclast formation, signaling, and bone resorption suggesting a biphasic relationship between RANKL (zeige TNFSF11 Antikörper)/RANK affinity and osteoclastogenic capacity.
Dissection of the mechanism by which this occurs indicates that mCripto-1 activates receptor activator NF-kappaB (zeige NFKB1 Antikörper)/receptor activator NF-kappaB (zeige NFKB1 Antikörper) ligand, and NF-kappaB (zeige NFKB1 Antikörper) signaling pathways.
We also show that R-spondin1 (zeige RSPO1 Antikörper) is depleted in RANK-null progenitors, and that its exogenous administration rescues key aspects of RANK deficiency by reinstating a WNT (zeige WNT2 Antikörper) response and mammary cell expansion
In this study, whole exome sequencing (WES) was successfully used in six patients with malignant infantile osteopetrosis (zeige CSF1 Antikörper) (MIOP) and identified mutations in four MIOP-related genes (CLCN7 (zeige CLCN7 Antikörper), TCIRG1 (zeige TCIRG1 Antikörper), SNX10 (zeige SNX10 Antikörper), and TNFRSF11A).
triple-negative breast cancer (TNBC) patients that expressed both RANK and RANKL (zeige TNFSF11 Antikörper) proteins had significantly worse RFS and OS than patients with RANK-positive, RANKL (zeige TNFSF11 Antikörper)-negative tumors. RANKL (zeige TNFSF11 Antikörper) was an independent, poor prognostic factor for RFS and OS in multivariate analysis in samples that expressed both RANK and RANKL (zeige TNFSF11 Antikörper).
RANK is increased in hormone receptor (zeige NR4A1 Antikörper) negative and basal breast cancer, and correlates with worse recurrence-free survival and risk of bone metastasis.
Studies showed that the central hypothalamic-pituitary regulatory system, via it's relative hormones, seems to control OPG/RANKL (zeige TNFSF11 Antikörper)/RANK system function, and the pulsatility and circadian rhythmicity of these hormones may induce an oscillatory fluctuation of the OPG/ RANKL (zeige TNFSF11 Antikörper) ratio. Also, psycological characteristics may provoke a shift of the OPG/ RANKL (zeige TNFSF11 Antikörper) ratio towards an unbalanced or a balanced status. [review]
Studies strongly implicates RANK and RANKL as key molecules involved in the initiation of BRCA1-associated breast cancer. [review]
RANK is frequently expressed by cancer cells in contrast with RANKL (zeige TNFSF11 Antikörper) which is frequently detected in the tumor microenvironment, and together they participate in every step in cancer development. (Review)
EGFR (zeige EGFR Antikörper) and RANK combinatorial in vitro analyses revealed a significant upregulation of AKT (zeige AKT1 Antikörper) and ERK (zeige EPHB2 Antikörper) signaling after EGF (zeige EGF Antikörper) stimulation in cell lines and also an increase of breast cancer cell invasiveness.
RANK/RANKL (zeige TNFSF11 Antikörper) signaling is involved in the androgen deprivation therapy-induced acceleration of bone metastasis in castration-insensitive prostate cancer and is inhibited by osteoprotegerin (zeige TNFRSF11B Antikörper) to prevent bone metastasis.
In histologically normal tissue of BRCA1-mutation carriers and showed that RANK(+) cells are highly proliferative, have grossly aberrant DNA repair and bear a molecular signature similar to that of basal-like breast cancer.
In this review, we will provide a summary of the biological functions of RANK signaling pathway (receptor activator of nuclear factor kappaB ligand RANKL (zeige TNFSF11 Antikörper) and its receptor RANK ) and downstream pathways in bone remodeling, immunity and epithelial homeostasis, with a particular emphasis on cancer
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.
tumor necrosis factor receptor superfamily member 11A
, tumor necrosis factor receptor superfamily, member 11a, NFKB activator
, receptor activator of nuclear factor-kappa B
, tumor necrosis factor receptor superfamily member 11A-like
, osteoclast differentiation factor receptor
, receptor activator of NF-KB
, receptor activator of NF-kappaB
, loss of heterozygosity, 18, chromosomal region 1