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RANK deficiency ameliorates podocyte injury by suppressing calcium/calcineurin/NFATc1 (zeige NFATC1 Proteine) signaling
TNFalpha and RANKL promote osteoclastogenesis by upregulating RANK via the NFkappaB pathway.
Results from this study demonstrate that RANK signalling in NPY (zeige NPY Proteine) neurons is involved in modulating NPY (zeige NPY Proteine) levels and through that matching bone mass to body weight.
the investigation of RANK and RANKL (zeige TNFSF11 Proteine) as possible novel immunotherapy targets in cancer is a rational approach. Here we have defined the mechanism of action of RANKL (zeige TNFSF11 Proteine)-RANK blockade in combination with anti-CTLA4 (zeige CTLA4 Proteine), and provide insight into the combination efficacy observed in the case reports.
Insulin induces RANK expression via ERK1/2, which contributes to the enhancement of osteoclast differentiation.
This indicated that RANK might be the binding target of baicalin. In sum, our findings revealed baicalin increased osteoclast maturation and function via p-ERK (zeige EPHB2 Proteine)/Mitf (zeige MITF Proteine) signalling. In addition, the results suggest that baicalin can potentially be used as a natural product for the treatment of bone fracture
RANKL (zeige TNFSF11 Proteine)/RANK control progenitor cell expansion and tumorigenesis in inherited breast cancer.
Artesunate inhibits RANKL (zeige TNFSF11 Proteine)-induced osteoclastogenesis by suppressing the NF-kappaB (zeige NFKB1 Proteine) signaling pathway.
Data suggest that mutations at position I248 in DE-loop of murine RANKL (zeige TNFSF11 Proteine) have effects on interaction of RANKL (zeige TNFSF11 Proteine) with RANK and on subsequent activation of osteoclastogenesis by this hetero-multimer. (RANKL (zeige TNFSF11 Proteine) = osteoclast differentiation factor (zeige TNFSF11 Proteine); RANK = tumor necrosis factor (zeige TNF Proteine) receptor superfamily, member 11a protein)
The persistence of bone erosion and synovial osteoclasts in Rank-deficient mice, and the ability of TNF (zeige TNF Proteine)/IL-6 (zeige IL6 Proteine) to induce osteoclastogenesis, suggest that more than one cytokine pathway exists to generate these bone-resorbing cells in inflamed joints.
gammadelta T cells suppressed iDCs osteoclastogenesis by downregulation of the RANK/cFos/ATP6V0D2 (zeige ATP6V0D2 Proteine) signaling pathway.
study identified the second disease gene for DOS. TNFRSF11A (zeige TNFRSF11A Proteine) isoforms may have the different roles in skeletal development and metabolism
The mRNA expression of RANK was highest in prostate tumour tissue from patients with bone metastases as compared to BPH or locally confined tumours, also shown in clinical subgroups distinguished by Gleason Score or PSA level.
For the RANK gene, the AGTGC haplotype was associated with the lowest risk of presenting chronic joint pain in individuals without TMD (zeige TTN Proteine) (P=0.03). This study supports the hypothesis that changes in the OPG (zeige TNFRSF11B Proteine) and RANK genes influence the presence of chronic joint pain in individuals with and without TMD (zeige TTN Proteine).
In this study, whole exome sequencing (WES) was successfully used in six patients with malignant infantile osteopetrosis (zeige CSF1 Proteine) (MIOP) and identified mutations in four MIOP-related genes (CLCN7 (zeige CLCN7 Proteine), TCIRG1 (zeige TCIRG1 Proteine), SNX10 (zeige SNX10 Proteine), and TNFRSF11A (zeige TNFRSF11A Proteine)).
triple-negative breast cancer (TNBC) patients that expressed both RANK and RANKL (zeige TNFSF11 Proteine) proteins had significantly worse RFS and OS than patients with RANK-positive, RANKL (zeige TNFSF11 Proteine)-negative tumors. RANKL (zeige TNFSF11 Proteine) was an independent, poor prognostic factor for RFS and OS in multivariate analysis in samples that expressed both RANK and RANKL (zeige TNFSF11 Proteine).
RANK is increased in hormone receptor (zeige NR4A1 Proteine) negative and basal breast cancer, and correlates with worse recurrence-free survival and risk of bone metastasis.
Studies showed that the central hypothalamic-pituitary regulatory system, via it's relative hormones, seems to control OPG/RANKL (zeige TNFSF11 Proteine)/RANK system function, and the pulsatility and circadian rhythmicity of these hormones may induce an oscillatory fluctuation of the OPG/ RANKL (zeige TNFSF11 Proteine) ratio. Also, psycological characteristics may provoke a shift of the OPG/ RANKL (zeige TNFSF11 Proteine) ratio towards an unbalanced or a balanced status. [review]
Studies strongly implicates RANK and RANKL as key molecules involved in the initiation of BRCA1-associated breast cancer. [review]
RANK is frequently expressed by cancer cells in contrast with RANKL (zeige TNFSF11 Proteine) which is frequently detected in the tumor microenvironment, and together they participate in every step in cancer development. (Review)
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.
osteoclast differentiation factor receptor
, receptor activator of NF-KB
, receptor activator of NF-kappaB
, tumor necrosis factor receptor superfamily member 11A
, loss of heterozygosity, 18, chromosomal region 1
, receptor activator of nuclear factor-kappa B