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RANKL (zeige TNFSF11 Proteine)/RANK control progenitor cell expansion and tumorigenesis in inherited breast cancer.
Artesunate inhibits RANKL (zeige TNFSF11 Proteine)-induced osteoclastogenesis by suppressing the NF-kappaB (zeige NFKB1 Proteine) signaling pathway.
Data suggest that mutations at position I248 in DE-loop of murine RANKL (zeige TNFSF11 Proteine) have effects on interaction of RANKL (zeige TNFSF11 Proteine) with RANK and on subsequent activation of osteoclastogenesis by this hetero-multimer. (RANKL (zeige TNFSF11 Proteine) = osteoclast differentiation factor (zeige TNFSF11 Proteine); RANK = tumor necrosis factor (zeige TNF Proteine) receptor superfamily, member 11a protein)
The persistence of bone erosion and synovial osteoclasts in Rank-deficient mice, and the ability of TNF (zeige TNF Proteine)/IL-6 (zeige IL6 Proteine) to induce osteoclastogenesis, suggest that more than one cytokine pathway exists to generate these bone-resorbing cells in inflamed joints.
Muscle RANK deletion had no significant effects on the sham or denervated slow-twitch soleus muscles. These data identify a novel role for RANK as a key regulator of Ca(2 (zeige CA2 Proteine)+)storage and SERCA (zeige ATP2A3 Proteine) activity, ultimately affecting denervated skeletal muscle function.
present study shows that ginsenoside Rg3 protects against LPS (zeige TLR4 Proteine)-induced acute lung injury through inactivating the NF-kappaB (zeige NFKB1 Proteine) signaling
In palmatine-treated mice, RANKL (zeige TNFSF11 Proteine) and OPG (zeige TNFSF11 Proteine) expression decreased. In the culture supernatant of MC3T3-E1 cells, RANKL (zeige TNFSF11 Proteine) and OPG (zeige TNFSF11 Proteine) levels were significantly reduced by palmatine addition.
Results show that moderate increases in affinity for RANK lead to a substantial augmentation of osteoclast formation, signaling, and bone resorption suggesting a biphasic relationship between RANKL (zeige TNFSF11 Proteine)/RANK affinity and osteoclastogenic capacity.
Dissection of the mechanism by which this occurs indicates that mCripto-1 activates receptor activator NF-kappaB (zeige NFKB1 Proteine)/receptor activator NF-kappaB (zeige NFKB1 Proteine) ligand, and NF-kappaB (zeige NFKB1 Proteine) signaling pathways.
We also show that R-spondin1 (zeige RSPO1 Proteine) is depleted in RANK-null progenitors, and that its exogenous administration rescues key aspects of RANK deficiency by reinstating a WNT (zeige WNT2 Proteine) response and mammary cell expansion
RANK is increased in hormone receptor (zeige NR4A1 Proteine) negative and basal breast cancer, and correlates with worse recurrence-free survival and risk of bone metastasis.
Studies showed that the central hypothalamic-pituitary regulatory system, via it's relative hormones, seems to control OPG/RANKL (zeige TNFSF11 Proteine)/RANK system function, and the pulsatility and circadian rhythmicity of these hormones may induce an oscillatory fluctuation of the OPG/ RANKL (zeige TNFSF11 Proteine) ratio. Also, psycological characteristics may provoke a shift of the OPG/ RANKL (zeige TNFSF11 Proteine) ratio towards an unbalanced or a balanced status. [review]
Studies strongly implicates RANK and RANKL as key molecules involved in the initiation of BRCA1-associated breast cancer. [review]
RANK is frequently expressed by cancer cells in contrast with RANKL (zeige TNFSF11 Proteine) which is frequently detected in the tumor microenvironment, and together they participate in every step in cancer development. (Review)
EGFR (zeige EGFR Proteine) and RANK combinatorial in vitro analyses revealed a significant upregulation of AKT (zeige AKT1 Proteine) and ERK (zeige EPHB2 Proteine) signaling after EGF (zeige EGF Proteine) stimulation in cell lines and also an increase of breast cancer cell invasiveness.
RANK/RANKL (zeige TNFSF11 Proteine) signaling is involved in the androgen deprivation therapy-induced acceleration of bone metastasis in castration-insensitive prostate cancer and is inhibited by osteoprotegerin (zeige TNFRSF11B Proteine) to prevent bone metastasis.
In histologically normal tissue of BRCA1-mutation carriers and showed that RANK(+) cells are highly proliferative, have grossly aberrant DNA repair and bear a molecular signature similar to that of basal-like breast cancer.
In this review, we will provide a summary of the biological functions of RANK signaling pathway (receptor activator of nuclear factor kappaB ligand RANKL (zeige TNFSF11 Proteine) and its receptor RANK ) and downstream pathways in bone remodeling, immunity and epithelial homeostasis, with a particular emphasis on cancer
Our results suggest that the polymorphism of the RANKL (zeige TNFSF11 Proteine), RANK, and OPG (zeige TNFRSF11B Proteine) genes does not make a significant genetic contribution to heel ultrasound measurements in a population of young Caucasian adults. Further studies replicating the results in independent populations are needed to support these initial findings.
Vav3 (zeige VAV3 Proteine) is a novel TRAF6 (zeige TRAF6 Proteine) interaction partner that functions in the activation of cooperative signaling between T6BSs and the IVVY motif in the RANK signaling complex.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.
osteoclast differentiation factor receptor
, receptor activator of NF-KB
, receptor activator of NF-kappaB
, tumor necrosis factor receptor superfamily member 11A
, loss of heterozygosity, 18, chromosomal region 1
, receptor activator of nuclear factor-kappa B