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Protein kinase c activity restricts dendritic arborization during embryonic brain circuit development through synaptotropic stabilization of dynamic processes.
PKCzeta promoted lung adenocarcinoma invasion and metastasis, and its expression was associated with MMP2 (zeige MMP2 Proteine) and MMP9 (zeige MMP9 Proteine) expression.
PKC-zeta may be responsible for the abnormal growth, proliferation, and migration of metastatic LOVO colon cancer cells via PKC-zeta/Rac1/Pak1 (zeige PAK1 Proteine)/beta-Catenin (zeige CTNNB1 Proteine) pathway.
reduced expression of PKCzeta/Pard3 (zeige PARD3 Proteine)/Pard6 contributes to non-small-cell lung cancer epithelial-mesenchymal transition, invasion, and chemoresistance.
Intestinal I/R induced the membrane translocation and phosphorylation of PKCzeta. Pretreatment with the PKCzeta activator phosphatidylcholine (zeige SGMS2 Proteine) remarkably attenuated gut (zeige GUSB Proteine) injury by suppressing apoptosis. H/R induced PKCzeta to combine with TRAF2 (zeige TRAF2 Proteine), which was phosphorylated by PKCzeta at Ser (zeige SIGLEC1 Proteine)(55), but not at Ser (zeige SIGLEC1 Proteine)(11), under intestinal I/R or H/R conditions
these results conclude that miR (zeige MLXIP Proteine)-25 targets PKCzeta and protects osteoblastic cells from Dex via activating AMPK (zeige PRKAA1 Proteine) signaling.
PKCzeta was specifically involved in ACOT7 (zeige ACOT7 Proteine) depletion-mediated cell cycle arrest as an upstream molecule of the p53 (zeige TP53 Proteine)-p21 (zeige CDKN1A Proteine) signaling pathway in MCF7 human breast carcinoma and A549 human lung carcinoma cells.
we found that Wnt3a (zeige WNT3A Proteine) treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 (zeige DVL2 Proteine) and Dvl3 (zeige DVL3 Proteine). Our findings suggest a model of positive regulation of PKCzeta-mediated Dvl (zeige DVL2 Proteine) signaling activity, to produce a strong and sustained response to Wnt3a (zeige WNT3A Proteine) treatment by stabilizing Dvl (zeige DVL2 Proteine) protein levels.
The data demonstrate that PKCzeta expression regulates the maturation of neonatal T-cells into specific functional phenotypes and that environmental influences may work via PKCzeta to regulate these phenotypes and disease susceptibility.
This study demonstrated that zinc upregulates PKCzeta by activating GPR39 (zeige GPR39 Proteine) to enhance the abundance of ZO-1 (zeige TJP1 Proteine), thereby improving epithelial integrity in S. typhimurium-infected Caco-2 cells.
Inhibition of protein kinase C zeta expression in prostate cancer cells promoted chemotaxis of peripheral macrophages and acquisition of M2 phenotypic features. These results were further supported by the finding that silencing of endogenous protein kinase C zeta promoted the expression of prostate cancer cell-derived interleukin-4 (zeige IL4 Proteine) and interleukin-10 (zeige IL10 Proteine)
HIF regulation of HOIL-1L (zeige RBCK1 Proteine) targets the phosphorylated PKC-zeta for degradation and serves as an hypoxia-adaptive mechanism to stabilize the Na,K-ATPase (zeige ATP1A1 Proteine), avoiding significant lung injury.
Under physiological conditions, PKMzeta is the principal PKC isoform that maintains LTP (zeige SCP2 Proteine) and long-term memory. PKCiota/lambda can compensate for PKMzeta, and because other isoforms could also maintain synaptic facilitation, there may be a hierarchy of compensatory mechanisms maintaining memory if PKMzeta malfunctions. [Review]
aPKCzeta is required for the cellular organization of acto-non-muscle myosin II (NMII) cytoskeleton, for proper cell adhesion and directed cell migration.
This study demonstrates that the combination therapy of PKCzeta and COX-2 inhibitors can significantly inhibit melanoma metastasis in vitro and in vivo, which will be an efficient strategy for treatment of melanoma metastasis in clinics
the inhibition of PKCzeta or ceramide synthesis did not further improve glucose tolerance in Angptl4 (zeige ANGPTL4 Proteine)(-/-) mice, suggesting that these molecules were major downstream effectors of Angptl4 (zeige ANGPTL4 Proteine).
Immunoblotting, qPCR, ChIP and siRNA-mediated gene knockdown studies revealed that the activation of phosphatidylinositol 3-kinase/protein kinase C zeta pathways in poly(I:C)-stimulated cells underlies Sp1 (zeige SP1 Proteine) phosphorylation and recruitment to the mCRAMP promoter, leading to enhanced transcription
APPL1 (zeige APPL1 Proteine) enhances glucose uptake by modulating the activation and localization of PKCzeta, as well as its functional interaction with both PP2A (zeige PPP2R2B Proteine) and myosin IIa.
Findings indicate PDZRN3 (zeige PDZRN3 Proteine) regulates vascular permeability through a PKCzeta-containing complex.
Data (including data from studies in transgenic and knockout mice) suggest that Pkcz (protein kinase C zeta) activation is key for early compensatory pancreatic beta-cell proliferation in insulin (zeige INS Proteine) resistance (overweight and diabetes type 2) by regulating downstream signal transduction components mTOR (mammalian target of rapamycin (zeige FRAP1 Proteine) protein) and Ccnd2 (cyclin-D2 (zeige CCND2 Proteine)).
These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.
chronic exposure to hypoxia leads to the emergence of cells lacking anti-replication activity of PKCzeta in the pulmonary artery adventitia.
inhibition of NO production by Ang-1 (zeige ANGPT1 Proteine), via phosphorylation of eNOS (zeige NOS3 Proteine) on Thr (zeige TRH Proteine)(497) by PKC zeta, is responsible, at least in part, for inhibition of VEGF (zeige VEGFA Proteine)-stimulated endothelial permeability by Ang-1 (zeige ANGPT1 Proteine).
ceramide as a potent physiological modulator of the Na(+)-ATPase, participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta.
Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta.
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
protein kinase C, zeta
, protein kinase c type Z
, protein kinase C zeta type
, protein kinase C zeta type-like
, atypical protein kinase C
, protein kinase C zeta subspecies
, 14 - 3 - 3 - zeta isoform
, atypical protein kinase C zeta