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Protein kinase c activity restricts dendritic arborization during embryonic brain circuit development through synaptotropic stabilization of dynamic processes.
Intestinal I/R induced the membrane translocation and phosphorylation of PKCzeta. Pretreatment with the PKCzeta activator phosphatidylcholine (zeige SGMS2 Proteine) remarkably attenuated gut (zeige GUSB Proteine) injury by suppressing apoptosis. H/R induced PKCzeta to combine with TRAF2 (zeige TRAF2 Proteine), which was phosphorylated by PKCzeta at Ser (zeige SIGLEC1 Proteine)(55), but not at Ser (zeige SIGLEC1 Proteine)(11), under intestinal I/R or H/R conditions
these results conclude that miR (zeige MLXIP Proteine)-25 targets PKCzeta and protects osteoblastic cells from Dex via activating AMPK (zeige PRKAA1 Proteine) signaling.
PKCzeta was specifically involved in ACOT7 (zeige ACOT7 Proteine) depletion-mediated cell cycle arrest as an upstream molecule of the p53 (zeige TP53 Proteine)-p21 (zeige CDKN1A Proteine) signaling pathway in MCF7 human breast carcinoma and A549 human lung carcinoma cells.
we found that Wnt3a (zeige WNT3A Proteine) treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 (zeige DVL2 Proteine) and Dvl3 (zeige DVL3 Proteine). Our findings suggest a model of positive regulation of PKCzeta-mediated Dvl (zeige DVL2 Proteine) signaling activity, to produce a strong and sustained response to Wnt3a (zeige WNT3A Proteine) treatment by stabilizing Dvl (zeige DVL2 Proteine) protein levels.
The data demonstrate that PKCzeta expression regulates the maturation of neonatal T-cells into specific functional phenotypes and that environmental influences may work via PKCzeta to regulate these phenotypes and disease susceptibility.
This study demonstrated that zinc upregulates PKCzeta by activating GPR39 (zeige GPR39 Proteine) to enhance the abundance of ZO-1 (zeige TJP1 Proteine), thereby improving epithelial integrity in S. typhimurium-infected Caco-2 cells.
Inhibition of protein kinase C zeta expression in prostate cancer cells promoted chemotaxis of peripheral macrophages and acquisition of M2 phenotypic features. These results were further supported by the finding that silencing of endogenous protein kinase C zeta promoted the expression of prostate cancer cell-derived interleukin-4 (zeige IL4 Proteine) and interleukin-10 (zeige IL10 Proteine)
Here we provide the first evidence that PKC-zeta is a potential target for the treatment of COPD (zeige ARCN1 Proteine) by selective small molecules
Study provides evidence for a novel PKC-zeta to p47phox interaction that is required for cell transformation from blebbishields and ROS (zeige ROS1 Proteine) production in cancer cells.
FRET-based translocation assays reveal that insulin (zeige INS Proteine) promotes the association of both p62 (zeige GTF2H1 Proteine) and aPKC with the insulin (zeige INS Proteine)-regulated scaffold IRS-1 (zeige IRS1 Proteine).
the inhibition of PKCzeta or ceramide synthesis did not further improve glucose tolerance in Angptl4 (zeige ANGPTL4 Proteine)(-/-) mice, suggesting that these molecules were major downstream effectors of Angptl4 (zeige ANGPTL4 Proteine).
Immunoblotting, qPCR, ChIP and siRNA-mediated gene knockdown studies revealed that the activation of phosphatidylinositol 3-kinase/protein kinase C zeta pathways in poly(I:C)-stimulated cells underlies Sp1 (zeige SP1 Proteine) phosphorylation and recruitment to the mCRAMP promoter, leading to enhanced transcription
APPL1 (zeige APPL1 Proteine) enhances glucose uptake by modulating the activation and localization of PKCzeta, as well as its functional interaction with both PP2A (zeige PPP2R2B Proteine) and myosin IIa.
Findings indicate PDZRN3 (zeige PDZRN3 Proteine) regulates vascular permeability through a PKCzeta-containing complex.
Data (including data from studies in transgenic and knockout mice) suggest that Pkcz (protein kinase C zeta) activation is key for early compensatory pancreatic beta-cell proliferation in insulin (zeige INS Proteine) resistance (overweight and diabetes type 2) by regulating downstream signal transduction components mTOR (mammalian target of rapamycin (zeige FRAP1 Proteine) protein) and Ccnd2 (cyclin-D2 (zeige CCND2 Proteine)).
androstenedione administration increased Akt1 (zeige AKT1 Proteine) and PKC zeta phosphorylation in the muscle tissue of C57BL6 mice.
studies support a model wherein an alternative mechanism regulates PKCzeta-mediated insulin (zeige INS Proteine) signalling that does not utilize conventional activation via agonist-evoked phosphorylation at the activation loop
PKCzeta/p62 (zeige GTF2H1 Proteine) activation stimulated inflammatory cytokine production and enhanced IGF-I (zeige IGF1 Proteine)-stimulated VSMC proliferation
Neuronal NF1 (zeige NF1 Proteine)/RAS regulation of cyclic AMP (zeige TMPRSS5 Proteine) requires atypical PKC zeta activation, which is perturbed in neurofibromatosis type 1 (zeige NF1 Proteine).
These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.
chronic exposure to hypoxia leads to the emergence of cells lacking anti-replication activity of PKCzeta in the pulmonary artery adventitia.
inhibition of NO production by Ang-1 (zeige ANGPT1 Proteine), via phosphorylation of eNOS (zeige NOS3 Proteine) on Thr (zeige TRH Proteine)(497) by PKC zeta, is responsible, at least in part, for inhibition of VEGF (zeige VEGFA Proteine)-stimulated endothelial permeability by Ang-1 (zeige ANGPT1 Proteine).
ceramide as a potent physiological modulator of the Na(+)-ATPase, participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta.
Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta.
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
protein kinase C, zeta
, protein kinase c type Z
, protein kinase C zeta type
, protein kinase C zeta type-like
, atypical protein kinase C
, protein kinase C zeta subspecies
, 14 - 3 - 3 - zeta isoform
, atypical protein kinase C zeta