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Human MAP3K7 Protein expressed in Wheat germ - ABIN1310225
Salazar, Kashiwada, Krejci, Meyer, Casale, Hallowell, Wilcox, Donoghue, Thompson: Fibroblast growth factor receptor 3 interacts with and activates TGF?-activated kinase 1 tyrosine phosphorylation and NF?B signaling in multiple myeloma and bladder cancer. in PLoS ONE 2014
Show all 3 Pubmed References
overexpression of miR (zeige MLXIP Proteine)-20a reduced colony formation and tumor growth. Furthermore, the data revealed that the function of miR (zeige MLXIP Proteine)-20a was probably exerted via targeting the TAK1 expression. Overexpression of miR (zeige MLXIP Proteine)-20a sensitizes the osteosarcoma cells to chemotherapeutic drugs.
TGFbeta (zeige TGFB1 Proteine) and IL1beta (zeige IL1B Proteine) signaling interact at the SMAD2 (zeige SMAD2 Proteine)/3 level in human primary MSC (zeige MSC Proteine). Down-stream TGFbeta (zeige TGFB1 Proteine) target genes were repressed by IL1beta (zeige IL1B Proteine) independent of C-terminal SMAD2 (zeige SMAD2 Proteine) phosphorylation. We demonstrate that SMAD2 (zeige SMAD2 Proteine)/3 linker modifications are required for this interplay and identified TAK1 as a crucial mediator of IL1beta (zeige IL1B Proteine)-induced TGFbeta (zeige TGFB1 Proteine) signal modulation.
increased TAK1 expression may be involved in the progression of gastric cancer.
miR (zeige MLXIP Proteine)-146a, serving as a tumor suppressor, may significantly promote GC cell apoptosis by inhibition of the NF-kappaB (zeige NFKB1 Proteine) signaling pathway via targeting TAK1.
In conclusion, for the first time, we report that TRADD (zeige TRADD Proteine), TRAF2 (zeige TRAF2 Proteine), RIP1 (zeige UQCRFS1 Proteine) and TAK1 play a role in the regulating TNF-alpha (zeige TNF Proteine) signalling in human myometrium. These findings are of significance given the central role of TNF-alpha (zeige TNF Proteine) in the processes of human labour and delivery.
Rab1 (zeige RAB1A Proteine) is regulated by the host in a similar fashion, and that the innate immunity kinase TAK1 and Legionella effectors compete to regulate Rab1 (zeige RAB1A Proteine) by switch II modifications during infection.
nMet accelerated HCC (zeige FAM126A Proteine) tumorigenesis and metastasis via the activation of TAK1/NF-kappaB (zeige NFKB1 Proteine) pathway.
TAK1 protein expression increased in cartilage tissue from spinal tuberculosis patients.
TAK1 regulates Nrf2 (zeige GABPA Proteine) through modulation of Keap-p62/SQSTM1 (zeige SQSTM1 Proteine) interaction. This regulation is important for homeostatic antioxidant protection in the intestinal epithelium.
Overexpression of TAK1 was strongly associated with positive lymph node metastasis in pancreatic ductal adenocarcinoma.
Data indicate TNF receptor associated factor 6 (TRAF6 (zeige TRAF6 Proteine)) as an essential molecular switch leading to cardiac hypertrophy in a transforming growth factor beta-activated kinase 1 (TAK1), -dependent manner.
It is a key regulator of the toll (zeige TLR4 Proteine)-like receptor signaling pathway.
The conversion of Tak1 (zeige NR2C2 Proteine)-B to Tak1 (zeige NR2C2 Proteine)-A consistently led to significant accumulation of lipids in cultured AML12cells, as well as the dysregulation of several lipid metabolism-related genes in mouse liver. Different functional properties of the two isoforms may explain the conflicting functions previously reported for Tak1 (zeige NR2C2 Proteine).
demonstrate the efficiency of ad--siRNA-TAK1 (zeige NR2C2 Proteine) in controlling joint inflammation of Collagen-Induced Arthritis, which is associated with the suppression of the expression of pro-inflammatory cytokines and JNK (zeige MAPK8 Proteine) activation.
These data, in addition to the fact that Map3k7 is upregulated in the sinus venous-the source of cells for the SAN-suggest that Map3k7 may be an endogenous regulator of the SAN fate
These results present a novel in vivo function, the negative role of TAK1 (zeige NR2C2 Proteine) in marginal zone B-cell development that is likely associated with NF-kappaB2 activation.
Tnfr1 (zeige TNFRSF1A Proteine) deletion partially restored thymic and lung macrophages.
TAK1 (zeige NR2C2 Proteine) is required for PPARgamma (zeige PPARG Proteine) transactivation and promotes PPARgamma (zeige PPARG Proteine) transcriptional activity synergistically with TAK1 binding protein 1 (TAB1 (zeige TAB1 Proteine)).
inhibition of TAK1 (zeige NR2C2 Proteine) triggered two caspase 8 (zeige CASP8 Proteine) activation pathways through the induction of RIP1 (zeige RALBP1 Proteine)-FADD (zeige FADD Proteine)-caspase 8 (zeige CASP8 Proteine) complex as well as FLIP cleavage/degradation.
Transforming growth factor-beta activated kinase 1 (TAK1) regulation of sterol-regulatory element-binding proteins (SREBPs) critically contributes to the maintenance of liver homeostasis to prevent steatosis, which is a potentially important mechanism to prevent hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) development.
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2\; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
mitogen-activated protein kinase kinase kinase 7
, TGF-beta-activated kinase TAK1
, TGF-beta activated kinase 1
, TGF-beta-activated kinase 1
, transforming growth factor-beta-activated kinase 1
, mitogen activated protein kinase kinase kinase 7
, transforming growth factor beta-activated kinase 1