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Human MAP3K7 Protein expressed in Wheat germ - ABIN1310225
Salazar, Kashiwada, Krejci, Meyer, Casale, Hallowell, Wilcox, Donoghue, Thompson: Fibroblast growth factor receptor 3 interacts with and activates TGF?-activated kinase 1 tyrosine phosphorylation and NF?B signaling in multiple myeloma and bladder cancer. in PLoS ONE 2014
Show all 3 Pubmed References
Rab1 (zeige RAB1A Proteine) is regulated by the host in a similar fashion, and that the innate immunity kinase TAK1 and Legionella effectors compete to regulate Rab1 (zeige RAB1A Proteine) by switch II modifications during infection.
nMet accelerated HCC (zeige FAM126A Proteine) tumorigenesis and metastasis via the activation of TAK1/NF-kappaB (zeige NFKB1 Proteine) pathway.
TAK1 protein expression increased in cartilage tissue from spinal tuberculosis patients.
TAK1 regulates Nrf2 (zeige GABPA Proteine) through modulation of Keap-p62/SQSTM1 (zeige SQSTM1 Proteine) interaction. This regulation is important for homeostatic antioxidant protection in the intestinal epithelium.
Overexpression of TAK1 was strongly associated with positive lymph node metastasis in pancreatic ductal adenocarcinoma.
dysregulation of the TAK1 complex produces a close phenocopy of Frontometaphyseal Dysplasia caused by FLNA (zeige FLNA Proteine) mutations; furthermore, the pathogenesis of some of the filaminopathies caused by FLNA (zeige FLNA Proteine) mutations might be mediated by misregulation of signaling coordinated through the TAK1 signaling complex
although TAK1 is located at the crossroad of inflammation, immunity, and cancer, this study reports MAP3K7 mutations in a developmental disorder affecting mainly cartilage, bone, and heart
This study suggests that aberrant activity of TAK1 impairs autophagy and subsequently leads to alterations in the vitality of retinal pigment epithelial cells.
TAK1 may be an important factor involved in the pathogenesis of thyroid cancer, and targeted down-regulation of TAK1 may improve the prognosis of patients with thyroid cancer.
Loss of MAP3K7 are associated with esophageal squamous cell carcinoma.
demonstrate the efficiency of ad--siRNA-TAK1 (zeige NR2C2 Proteine) in controlling joint inflammation of Collagen-Induced Arthritis, which is associated with the suppression of the expression of pro-inflammatory cytokines and JNK (zeige MAPK8 Proteine) activation.
These data, in addition to the fact that Map3k7 is upregulated in the sinus venous-the source of cells for the SAN-suggest that Map3k7 may be an endogenous regulator of the SAN fate
These results present a novel in vivo function, the negative role of TAK1 (zeige NR2C2 Proteine) in marginal zone B-cell development that is likely associated with NF-kappaB2 activation.
Tnfr1 (zeige TNFRSF1A Proteine) deletion partially restored thymic and lung macrophages.
TAK1 (zeige NR2C2 Proteine) is required for PPARgamma (zeige PPARG Proteine) transactivation and promotes PPARgamma (zeige PPARG Proteine) transcriptional activity synergistically with TAK1 binding protein 1 (TAB1 (zeige TAB1 Proteine)).
inhibition of TAK1 (zeige NR2C2 Proteine) triggered two caspase 8 (zeige CASP8 Proteine) activation pathways through the induction of RIP1 (zeige RALBP1 Proteine)-FADD (zeige FADD Proteine)-caspase 8 (zeige CASP8 Proteine) complex as well as FLIP cleavage/degradation.
Transforming growth factor-beta activated kinase 1 (TAK1) regulation of sterol-regulatory element-binding proteins (SREBPs) critically contributes to the maintenance of liver homeostasis to prevent steatosis, which is a potentially important mechanism to prevent hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) development.
TAK1 (zeige NR2C2 Proteine) regulates Nrf2 (zeige NFE2L2 Proteine) through modulation of Keap-p62/SQSTM1 (zeige SQSTM1 Proteine) interaction. This regulation is important for homeostatic antioxidant protection in the intestinal epithelium.
Mekk1 (zeige MAP2K1 Proteine) (encoded by Map3k1 (zeige MAP3K1 Proteine)) signaling activates Mapks to regulate Cdkn1b (zeige CDKN1B Proteine) (encoding p27(Kip1 (zeige CDKN1B Proteine))) expression and p27(Kip1 (zeige CDKN1B Proteine))-dependent proliferative expansion in response to antigen.
TRADD (zeige TRADD Proteine) knockout blunts pressure overload-induced cardiac hypertrophy through mediating TAK1 (zeige NR2C2 Proteine)/p38 MAPK (zeige MAPK14 Proteine) but not AKT (zeige AKT1 Proteine) phosphorylation
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2\; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
mitogen-activated protein kinase kinase kinase 7
, TGF-beta-activated kinase TAK1
, TGF-beta activated kinase 1
, TGF-beta-activated kinase 1
, transforming growth factor-beta-activated kinase 1
, mitogen activated protein kinase kinase kinase 7
, transforming growth factor beta-activated kinase 1