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results suggest that changes in the relative concentrations of RelB, NIK:IKK1, and p100 during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100.
report a detailed state-of-the-art mass spectrometry-based protein-protein interaction network including the noncanonical NF-kappaB (zeige NFKB1 ELISA Kits) signaling nodes TRAF2 (zeige TRAF2 ELISA Kits), TRAF3 (zeige TRAF3 ELISA Kits), IKKalpha (zeige CHUK ELISA Kits), NIK, and NF-kappaB2/p100 (zeige CUX1 ELISA Kits); also provide a differential interactome of NIK mutants that cause immunodeficiency
OLFM1 (zeige OLFM1 ELISA Kits) is a negative regulator of non-canonical NF-kappaB (zeige NFKB1 ELISA Kits) signalling by interacting with and inhibiting NIK. Thus, OLFM1 (zeige OLFM1 ELISA Kits) may serve as a valuable biomarker and therapeutic target for colorectal cancer (CRC (zeige CALR ELISA Kits)) patients.
The expression of OTUD7B and NIK were negatively correlated in non-small cell lung cancer tumor samples. the higher expression of NIK was related to more lymph node metastasis and later TNM (zeige ODZ1 ELISA Kits) stage. high OTUD7B/low NIK index can predict an good prognosis.
NIK expression was significantly increased in the tumor tissue of patients with breast carcinoma, which may be an important factor that affects the prognosis of these patients.
This study identified two novel independent loci (MAP3K14 and CARD9 (zeige CARD9 ELISA Kits)) strongly associated with joint damage in Mexican Americans and European Americans and a few shared loci showing suggestive evidence for association.
The forced expression of NDRG2 in ATL cells down-regulates not only the canonical pathway by inhibiting AKT signaling but also the non-canonical pathway by inducing NF-kappaB-inducing kinase (NIK) dephosphorylation via the recruitment of PP2A
NIK(+) endothelial cells may play an important role in the persistence of synovitis
Data suggest microRNA302c, but not microRNA520e, promotes replication of influenza A virus H3N2 although the two microRNAs target same site of NFkappaB (zeige NFKB1 ELISA Kits)-inducing kinase (MAP3K14) 3prime untranslated region; studies were conducted in lung epithelial cells.
TWEAK (zeige TNFSF12 ELISA Kits) induces noncanonical NF-kappaB (zeige NFKB1 ELISA Kits) signaling and signal-specific regulation of NIK mRNA expression.
constitutive activation of NIK (zeige MAP4K4 ELISA Kits) in the hematopoietic system leads to bone marrow (BM) failure and postnatal lethality.
NIK (zeige MAP4K4 ELISA Kits) pathways in both hepatocytes and immune cells act in concert to promote liver steatosis and glucose production in the setting of obesity.
this study demonstrates that although NIK (zeige MAP4K4 ELISA Kits) is dispensable for thymocyte development, it has a cell-intrinsic role in regulating the homeostasis and function of peripheral T cells
Using a novel conditional mutant of NIK (zeige MAP4K4 ELISA Kits), the authors could show in vivo that NIK (zeige MAP4K4 ELISA Kits) signaling in thymic epithelial cells is essential for the thymic hardwiring of gammadelta T cell cytokine production.
NIK (zeige MAP4K4 ELISA Kits) not only contributes to lymphoid organogenesis, inflammation and cell survival but also to TNFR1 (zeige TNFRSF1A ELISA Kits)/RIP1 (zeige RALBP1 ELISA Kits)-dependent cell death independently of the alternative NF-kappaB (zeige NFKB1 ELISA Kits) pathway.
This study demonstrated that NFkappaB-inducing kinase inhibits NFkappaB activity specifically in neurons of the CNS.
results assign NIK (zeige MAP4K4 ELISA Kits)-induced alternative NF-kappaB (zeige NFKB1 ELISA Kits) signaling a master regulatory role in B-cells, starting from the T1 stage and also show that B-1 B cells are less dependent on this pathway, presumably owing to the existence of alternative pathways yet to be determined
NIK (zeige MAP4K4 ELISA Kits), and thus probably the noncanonical NF-kappaB (zeige NFKB1 ELISA Kits) pathway, is critical to allow DCs to acquire the capacity to cross-present antigen and prime CD8 (zeige CD8A ELISA Kits) T cells after exposure to licensing stimuli.
Deletion of NIK (zeige MAP4K4 ELISA Kits) in adult mice results in decreases in B cell populations in lymph nodes and spleen, similar to what is observed upon blockade of BAFF (zeige TNFSF13B ELISA Kits).
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
, serine/threonine protein-kinase
, serine/threonine-protein kinase NIK
, NF kappa B-inducing kinase
, Nfkb inducing kinase
, protein kinase
, mitogen-activated protein kinase kinase kinase 14