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these results reveal that the IL-1 (zeige IL1A Proteine)/IL-1R2 axis is differentially regulated in the remitting intestinal mucosa of ulcerative colitis patients
Data show that all the six inflammation-related CpG-SNPs genotypes including IL1B (zeige IL1B Proteine) rs16944, IL1R2 rs2071008, PLA2G7 (zeige Lp-PLA2 Proteine) rs9395208, FAM5C rs12732361, CD40 (zeige CD40 Proteine) rs1800686, and CD36 (zeige CD36 Proteine) rs2065666 were associated with coronary heart disease (CHD (zeige CHDH Proteine)), suggesting an important role of inflammation in the risk of CHD (zeige CHDH Proteine).
Expression level of IL1R2 was down regulated in cervical squamous cell carcinoma.
No significant differences in the lymphocyte mRNA levels of IL-1R2, IL-6R, and Gp130 were observed between MDD patients and NC. These studies suggest abnormal gene expression of these cytokines and their membrane-bound receptors in the lymphocytes of MDD patients, and that their mRNA expression levels in the lymphocytes could be a useful biomarker for depression.
IL1R2 rs2310173 genotype GT was mildly protective against ankylosing spontylitis only in HLA-B27-negative patients.
IL1R2 hypomethylation and androgen receptor (zeige AR Proteine) hypermethylation may constitute an important determinant of disease severity, whereas NPR2 (zeige NPRL2 Proteine) hypomethylation and SP140 (zeige SP140 Proteine) hypermethylation may provide a biomarker for vulnerability to excessive daytime sleepiness in Obstructive Sleep Apnea
This is the first detection that the genetic variation rs2302589 in IL-1R2 gene was associated with ankylosing spondylitis in Northern Han Chinese.
Data show that interleukin-1 receptor type 2 (IL1R2) forms a complex with c-Fos proto-oncogene protein and activates the interleukin-6 (IL-6 (zeige IL6 Proteine)) and vascular endothelial growth factor A (VEGF-A (zeige VEGFA Proteine)) promoters.
Cerebrospinal fluid soluble interleukin-1 Receptor II, but not log interleukin-6 (zeige IL6 Proteine), levels were positively correlated with a composite measure of aggression.
results suggested that IL1R2 could have oncogenic potential in osteosarcoma
Thus, we show that IL-1R2 is harmful for the development of colitis, because IL-1R2 promotes the growth of proinflammatory intestinal microbiota by suppressing IL-1beta (zeige IL1B Proteine)-induced AMP (zeige TMPRSS5 Proteine) production.
Our data demonstrate that the decoy receptor IL-1R2 plays an important inhibitory role in local IL-1 (zeige IL1A Proteine)- and neutrophil-dependent tissue inflammation
Data indicate that a disintegrin and metallopeptidase domain 17 (ADAM17 (zeige ADAM17 Proteine)) regulates interleukin (IL)-1 (zeige IL1A Proteine) signaling via cleavage of IL-1 (zeige IL1A Proteine) receptor type 2 (IL-1R2).
IL-1 (zeige IL1A Proteine) receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 (zeige IL1A Proteine) signal on macrophages.
Interleukin-1 receptor type II is significantly upregulated in decidual cells close to the embryo during days 5 to 8 of pregnancy.
Data show that bee venom detected by inflammasome and trigger activation of caspase-1 (zeige CASP1 Proteine) and secretion of proinflammatory cytokine IL-1beta (zeige IL1B Proteine) is pyrin domain-containing 3 NLRP3 (zeige NLRP3 Proteine), apoptosis-associated speck-like protein ASC (zeige STS Proteine), and IL-1 (zeige IL1A Proteine) receptor dependent.
inoculation of young CD4 (zeige CD4 Proteine)(+) T cells or a fetal thymus graft led to down regulation of the interleukin 1 receptor type II (IL-1R2) gene in CD4 (zeige CD4 Proteine)(+) T cells and reduced age-related hearing loss
BACE1 (zeige BACE Proteine) and BACE2 (zeige BACE2 Proteine) may act as alternative alpha-secretase-like proteases in proteolytic processing of IL-1R2 and APP (zeige APP Proteine)
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage.
interleukin-1 receptor type 2
, soluble type II IL-1 receptor
, CD121 antigen-like family member B
, IL-1 type II receptor
, antigen CDw121b
, interleukin 1 receptor type II variant 3
, interleukin-1 receptor beta
, interleukin-1 receptor type II
, type II interleukin-1 receptor, beta
, IL-1 receptor beta chain