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Mouse (Murine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1305081
Gray, Glaister, Chen, Goeddel, Pennica: Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta. in Journal of immunology (Baltimore, Md. : 1950) 1986
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Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN413480
Kahlenberg, Thacker, Berthier, Cohen, Kretzler, Kaplan: Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus. in Journal of immunology (Baltimore, Md. : 1950) 2011
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Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1589581
Hollborn, Vogler, Reichenbach, Wiedemann, Bringmann, Kohen: Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5. in Molecular vision 2015
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Rat (Rattus) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN809718
Yang, Poon, Luo, Cheung, Ho, Lo, Fan: Up-regulation of vascular endothelial growth factor (VEGF) in small-for-size liver grafts enhances macrophage activities through VEGF receptor 2-dependent pathway. in Journal of immunology (Baltimore, Md. : 1950) 2004
Mouse (Murine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN804033
Tiwari, Wang, Brochetta, Ke, Vita, Qi, Rivera, Soranzo, Zabucchi, Hong, Blank: VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways. in Blood 2008
Mouse (Murine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN988112
Zhang, Bennett, Verkman: Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms. in Annals of neurology 2011
Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1305079
Kitamura, Tange, Terasawa, Chiba, Kuwaki, Miyagawa, Piao, Miyazono, Urabe, Takaku: Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. in Journal of cellular physiology 1989
This study reveals that proper levels of Il1b signaling and tissue inflammation, which are tuned by macrophages, play a crucial role in tissue regeneration.
Leukocyte expression of IL-1beta was detectable only following injury, which activated leukocytes throughout zebrafish embryos in a caspase (zeige CASP3 Proteine) dependent manner.
Embryo and larva leukocytes upregulate IL-1beta expression proportional to the dose of ultraviolet radiation exposure in an immune response at the organismal level.
findings reveal that the Il-1beta-Myd88 (zeige MYD88 Proteine) axis and NADPH oxidase (zeige NOX1 Proteine)-mediated ROS (zeige ROS1 Proteine) signaling are two independent pathways that differentially regulate neutrophil migration during sterile inflammation.
the expression levels of IL-1beta and TNF-alpha in high cholesterol diet (HCD)-fed zebrafish larvae
These results represent the first demonstration of processing and secretion of zebrafish IL-1beta in response to a pathogen.
In fibrocystin/polyductin complex-defective cholangiocytes, beta-catenin and IL-1beta are responsible for signal transducer and activator of transcription 3-dependent secretion of CXCL10
These results suggest that mitochondrial ROS (zeige ROS1 Proteine)-TXNIP (zeige TXNIP Proteine)/NLRP3 (zeige NLRP3 Proteine)/IL-1beta axis activation is responsible for tubular oxidative injury, which can be ameliorated by MitoQ via the inhibition of mtROS overproduction
Circadian clock protein BMAL1 (zeige ARNTL Proteine) regulates IL-1beta in macrophages via NRF2 (zeige NFE2L2 Proteine).
TLR2 and NLRP3 (zeige NLRP3 Proteine) inflammasome activation in cardiac macrophages mediate the production of IL-1beta in diabetic mice. IL-1beta causes prolongation of the action potential duration, induces a decrease in potassium current and an increase in calcium sparks in cardiomyocytes, which are changes that underlie arrhythmia propensity.
show that mutant KRAS facilitates IKKalpha (zeige CHUK Proteine)-mediated responsiveness of tumor cells to host IL-1beta, thereby establishing a host-to-tumor signaling circuit that culminates in inflammatory MPE development and drug resistance
identify interleukin-1 beta as an upstream trigger for the upregulation of interactions between USP5 (zeige USP5 Proteine) and Cav3.2 (zeige CACNA1H Proteine) channels in the pain pathway
The present study demonstrated that IL-1b may induce ICAM-1 (zeige ICAM1 Proteine) expression, thus enhancing the cohesion between mesenchymal stem cells and endothelial progenitor cells via the p38 MAPK (zeige MAPK14 Proteine) signaling pathway.
SAG2A differentially modulates IL-1beta expression in resistant and susceptible murine peritoneal macrophages cells.
High IL-1beta expression is associated with experimental autoimmune encephalomyelitis.
tibias of botulin A toxin-treated and tail-suspended mice, which featured unloading and decreased bone mass, showed higher expression of IL-1beta, Lcn2 and Nos2, suggesting their pathophysiologic involvement in endothelial cell-osteoblast crosstalk.
Taken together, the silencing of H4R (zeige HRH4 Proteine) inhibited the H4R (zeige HRH4 Proteine) mediated Mast cell functions and SAPK (zeige MAPK9 Proteine)/JNK (zeige MAPK8 Proteine) phosphorylation. Furthermore, the H4R (zeige HRH4 Proteine) activation utilized SAPK (zeige MAPK9 Proteine)/JNK (zeige MAPK8 Proteine) signaling pathway for IL-1beta release in HMC-1 cells
IL-1beta/IL-6 (zeige IL6 Proteine) network is highly expressed in the colorectal cancer (CRC (zeige CALR Proteine)) microenvironment, indicating that this network is important in the progression of CRC (zeige CALR Proteine)
Findings revealed an HIF-1alpha (zeige HIF1A Proteine)/IL-1beta signaling loop between cancer cells and tumor-associated macrophages in a hypoxic microenvironment, resulting in cancer cell epithelial-mesenchymal transition and metastasis; more importantly, our results suggest a potential role of an anti-inflammatory strategy in hepatocellular carcinoma treatment
Colombian individuals with high African ancestry proportions at locus 2q14 harbour more IL1B-CGTC copies and are consequently at an increased risk of colorectal cancer.
Study found a statistically significant association between the IL-1B rs16944 polymorphism and febrile seizures (FS) risk in Caucasians and Asians. The TT+CT genotypes were associated with a 1.43 times increased risk for FS in Caucasians, while an increased risk of 1.39 times was observed for FS development for the TT homozygotes in Asians.
Preincubation of LAD2 cells with the natural flavonoid methoxyluteolin (1-100 mM) inhibits (P < 0.0001) secretion and gene expression of IL-1beta, procaspase-1, and pro-IL-1beta. Mast cell secretion of IL-1beta in response to SP and IL-33 (zeige IL33 Proteine) reveals targets for the development of antiinflammatory therapies.
in Caco-2 CFTR (zeige CFTR Proteine)-shRNA cells, the EGFR (zeige EGFR Proteine) ligand EREG (zeige EREG Proteine) is overexpressed due to an active IL-1beta autocrine loop that indirectly activates EGFR (zeige EGFR Proteine), constituting new signaling effectors for the CFTR (zeige CFTR Proteine) signaling pathway, downstream of CFTR (zeige CFTR Proteine), Cl(-) , and IL-1beta.
The single nucleotide polymorphism (SNP) of IL-1beta gene (rs3917356G>A) increased the risk of HCC (zeige FAM126A Proteine) in the recessive model (p<0.001, OR=2.58, 95% CI=1.53-4.33), whereas other SNPs in IL-1alpha and IL-1RA (zeige IL1RN Proteine) showed no significant association between Hepatocellular carcinoma patients and controls.
Caspase-1 (zeige CASP1 Proteine)-dependent IL-1beta processing and secretion require the AIM2 (zeige AIM2 Proteine) inflammasome pathway in human dental pulp cells and the AIM2 (zeige AIM2 Proteine) inflammasome pathway is critical for regulation of the dental pulp immune response.
Genetic Polymorphisms of IL1B, IL6, and TNFalpha in a Chinese Han Population with Pulmonary Tuberculosis.
Analysis of host-protein interactions for African swine fever virus L83L identified IL-1beta as its host ligand. A recombinant African swine fever virus lacking the L83L was developed from the highly virulent field isolate Georgia2007 and was used to show that L83L is a non-essential gene.
This study showed that the presence of embryos in oviducts on days 2-3 after mating may influence the oviductal expression of the members of the IL-1beta system, determining the action of IL-1beta, which may be considered to be the earliest sign of pregnancy in pigs.
This study showed that classical swine fever virus and p7 protein induced IL-1beta secretion and that p7 protein was a short-lived protein degraded by the proteasome.
local expression of IL-1beta and IL-8 (zeige IL8 Proteine) in non-bacterial thrombotic endocarditis, Staphylococcus aureus infective endocarditis, animals with S. aureus sepsis without endocarditis and controls
IL1B regulates expression of IL1R1 (zeige IL1RN Proteine) and IL1RAP (zeige IL1RAP Proteine) and stimulates expression of PTGS1 (zeige PTGS1 Proteine) and PTGS2 (zeige PTGS2 Proteine) that are considered to be the most rate-limiting enzymes for endometrial synthesis of prostaglandins during the peri (zeige PLIN1 Proteine)-implantation period of pregnancy in pigs.
the results presented here strongly suggest IL-1beta as a key molecule guiding tissue remodelling events after myocardial infarction.
Mycobacterium bovis infected animals have a higher frequency of IFN-gamma (zeige IFNG Proteine) producing CD4 (zeige CD4 Proteine)(+) T cells and elevated plasma IL-1beta levels.
The presence of embryos increased endometrial IL1B protein locally, while no differences regarding IL1R1 (zeige IL1RN Proteine) protein and IL1B and IL1R1 (zeige IL1RN Proteine) mRNA were detected.
For the inflammasome-dependent IL-1beta release, bovine monocytes require ATP in addition to a primary stimulus. This IL-1beta release depends on potassium efflux, but, in contrast to human and murine monocytes, does not require calcium influx or generation of reaction oxygen and is independent of the P2X7 receptor (zeige P2RX7 Proteine).
Role of TGF-beta1 (zeige TGFB1 Proteine) and TNF-alpha (zeige TNF Proteine) in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.
Testicular IL-1 alpha (zeige IL1A Proteine) and IL-1 beta concentrations were highest in the early post-natal period; however, IL-1 (zeige IL1A Proteine) bioactivity and IL-6 (zeige IL6 Proteine) concentrations were greatest in the immediate pre-pubertal period.
Data describe the expression of IL-8 (zeige IL8 Proteine), IL-1beta and their respective receptors, CXCR1 (zeige CXCR1 Proteine) and IL-1R1 in bovine theca cells, and suggest that VEGF (zeige VEGFA Proteine) is associated with the IL system in theca cells in ovary.
Genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta may have different roles as regulating PGF (zeige PGF Proteine)(2alpha) and PGE (zeige LIPF Proteine)(2) production during luteal phase.
non-metalloproteinase mechanisms participate in IL-1 (zeige IL1A Proteine)-induced matrix degradation and loss of tissue material properties
dynamic compression stimulates cell proliferation and proteoglycan (zeige Vcan Proteine) synthesis in the presence of IL-1beta and/or inhibitors of the MAPKs and NFkappaB and AP-1 (zeige JUN Proteine) signalling pathways
These results indicate that activation of the intrinsic antistaphylococcal response in bovine endothelial cells (BEC), enhanced by TNF-alpha (zeige TNF Proteine) and IL-1beta, is effective to eliminate S. aureus and S. epidermidis.
Mild heat shock increased the production of inflammatory cytokines, IL-1beta and IL-6 (zeige IL6 Proteine) in rabbit cornea cells.
IL-1beta and TNF-alpha (zeige TNF Proteine) expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta and TNF-alpha (zeige TNF Proteine).
IL-1beta induced a significant reduction in the relative intrinsic activity of GLUT5 and in this decrease are involved NO signal pathways; blockage of D-fructose intestinal uptake by IL-1beta may play an essential role in the pathophysiology of septic shock.
The inhibitory effect of IL-1beta on D-galactose absorption across mucosal side of enterocyte could be mediated by the activation of several kinases and nuclear factor kappa B.
Glucosamine hydrochloride treatment can can partially decrease the expression levels of IL-1 beta and increase the expression levels of TGF-beta 1 (zeige TGFB1 Proteine), which delays the development of osteoarthritis.
In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of IL1B transcripts depending on luteal stage.
results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta,COX-2, and TGFbeta1 (zeige TGFB1 Proteine)
Increased PGE2 production led to reduction in 5-LO (zeige ALOX5 Proteine) products in LPS (zeige IRF6 Proteine)-treated equine whole blood via IL-1b.
Results suggested that chemokine (zeige CCL1 Proteine) expression by cultured equine BECs following exposure to pulmonary hemorrhage conditions may contribute to the development of inflammatory airway disease in horses.
IL-1beta-induced up-regulation of matrix metalloproteinase 13 (zeige MMP13 Proteine) mRNA was blocked by all concentrations of geldanamycin tested
This study examined effects of in vitro exposure to solutions of hay (zeige GTF2H5 Proteine) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
, IL-1 beta
, interleukin-1 beta
, preinterleukin 1 beta
, prointerleukin-1 beta
, Interleukin-1 beta
, precursor interleukin-1beta
, interleukin-1 beta proprotein
, interleukin 1 beta
, lymphocyte proliferation-potentiating factor