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Mouse (Murine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1305081
Gray, Glaister, Chen, Goeddel, Pennica: Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta. in Journal of immunology (Baltimore, Md. : 1950) 1986
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Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1589581
Hollborn, Vogler, Reichenbach, Wiedemann, Bringmann, Kohen: Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5. in Molecular vision 2015
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Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN413480
Kahlenberg, Thacker, Berthier, Cohen, Kretzler, Kaplan: Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus. in Journal of immunology (Baltimore, Md. : 1950) 2011
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Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1305079
Kitamura, Tange, Terasawa, Chiba, Kuwaki, Miyagawa, Piao, Miyazono, Urabe, Takaku: Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. in Journal of cellular physiology 1989
Mouse (Murine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN988112
Zhang, Bennett, Verkman: Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms. in Annals of neurology 2011
Rat (Rattus) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN809718
Yang, Poon, Luo, Cheung, Ho, Lo, Fan: Up-regulation of vascular endothelial growth factor (VEGF) in small-for-size liver grafts enhances macrophage activities through VEGF receptor 2-dependent pathway. in Journal of immunology (Baltimore, Md. : 1950) 2004
Mouse (Murine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN804033
Tiwari, Wang, Brochetta, Ke, Vita, Qi, Rivera, Soranzo, Zabucchi, Hong, Blank: VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways. in Blood 2008
This study reveals that proper levels of Il1b signaling and tissue inflammation, which are tuned by macrophages, play a crucial role in tissue regeneration.
Leukocyte expression of IL-1beta was detectable only following injury, which activated leukocytes throughout zebrafish embryos in a caspase (zeige CASP3 Proteine) dependent manner.
Embryo and larva leukocytes upregulate IL-1beta expression proportional to the dose of ultraviolet radiation exposure in an immune response at the organismal level.
findings reveal that the Il-1beta-Myd88 (zeige MYD88 Proteine) axis and NADPH oxidase (zeige NOX1 Proteine)-mediated ROS (zeige ROS1 Proteine) signaling are two independent pathways that differentially regulate neutrophil migration during sterile inflammation.
the expression levels of IL-1beta and TNF-alpha in high cholesterol diet (HCD)-fed zebrafish larvae
These results represent the first demonstration of processing and secretion of zebrafish IL-1beta in response to a pathogen.
Inhibition of signaling stimulated by both TNF (zeige TNF Proteine) and IL1beta synergizes with NF-kappaB (zeige NFKB1 Proteine) inhibition in eliminating leukemic stem cells.
Parenchymal polymorphonuclear myeloid-derived suppressor cell (PMN (zeige TBCE Proteine)-MDSC), have a positive correlation with IL1a (zeige IL1A Proteine), IL8 (zeige IL8 Proteine), CXCL5 (zeige CXCL5 Proteine), and Mip-1a (zeige CCL3 Proteine), suggesting they may attract PMN (zeige TBCE Proteine)-MDSC into the tumor
Chemokine receptor 2 (CCR2 (zeige CCR2 Proteine)(+)) monocytes invade the hippocampus between 1 and 3 d after SE. In contrast, only an occasional CD3 (zeige CD3E Proteine)(+) T lymphocyte was encountered 3 d after SE. The initial cellular sources of the chemokine (zeige CCL1 Proteine) CCL2 (zeige CCL2 Proteine), a ligand for CCR2 (zeige CCR2 Proteine), included perivascular macrophages and microglia. The induction of the proinflammatory cytokine IL-1beta was greater in FACS-isolated microglia than in brain-invading monocytes
hypernociception in experimental model of autoimmune encephalomyelitis may be a consequence of the increase in some cytokines in dorsal root ganglia, especially IL-1beta.
An OA model was established in mouse articular chondrocytes (MACs) treated by interleukin-1beta (IL-1beta).
The current study demonstrated that honey can stimulate or suppress the mRNA expression of some pro-inflammatory cytokines in mice brains. Furthermore, honey suppresses the TNF-alpha (zeige TNF Proteine) mRNA expression in the presence of T. gondii infection but it stimulates the IL-1beta and IL-6 (zeige IL6 Proteine) mRNA expression. Treatment of the mice with honey reduces parasite multiplication in the brain.
IL-1beta has a direct effect on NGAL (zeige LCN2 Proteine) production by tubular epithelial cells.
Following vasectomy, IL1alpha (zeige IL1A Proteine), IL1beta, IL1ra (zeige IL1RN Proteine), IL10 (zeige IL10 Proteine), and TNF-alpha (zeige TNF Proteine) may mediate immune reaction in whole epididymis, whereas IL6 (zeige IL6 Proteine) and TGF-beta1 (zeige TGFB1 Proteine) may mediate regionally different immune response primarily in the lower part of epididymis.
Elevations of CO2 cause oligomerization of the inflammasome components ASC (zeige STS Proteine), NLRP3 (zeige NLRP3 Proteine), caspase 1 (zeige CASP1 Proteine), thioredoxin interacting protein (zeige TXNIP Proteine), and calreticulin (zeige CALR Proteine) - a protein from endoplasmic reticulum, leading to IL-1beta synthesis. An increased production rate of MPs containing elevated amounts of IL-1beta persists for hours after short-term exposures to elevated CO2
dimerized or endogenous caspase-8 (zeige CASP8 Proteine) can also directly cleave IL-1beta into its biologically active form, in the absence of canonical inflammasome components.
The genotypic polymorphisms of IL-1beta -511 and +3954, and of MUC7 (zeige MUC7 Proteine) VNTR, had no direct associations with the development of BMS. However, the T allele of IL-1beta -511 may increase the risk of BMS by increasing psychological asthenia.
our study has described the association between rs3783550 (IL-1A), rs3783546 (IL-1A) and rs2853550 (IL-1B) and AS risk and between a new haplotype, "TCG", of rs3783550, rs3783546 and rs2853550 and AS in Chinese Han population.
serum levels of IL-1beta were able to prognostically stratify our cohort of iDCM patients. The precise cut-off of IL-1beta associated with bad outcome in iDCM remains to be determined in larger, independent cohorts of patients.
Biological complications in implant-supported overdentures were found to be mostly associated with the presence of allele 2 of the IL1B gene.
High interleukin 1 beta expression is associated with neuroinflammation.
Data show that cyclic stretch activated the nucleotide-binding oligomerization domain-like receptor containing pyrin (zeige MEFV Proteine) domain 1 and 3 (NLRP1 and NLRP3 (zeige NLRP3 Proteine)) inflammasomes and induced the release of IL-1beta and pyroptosis via a caspase-1 (zeige CASP1 Proteine)-related mechanism in human periodontal ligament cells (HPDLCs).
Our findings suggest that there is a prevalence of mutated allele of IL-1 (zeige IL1A Proteine) gene cluster in our population, which may be responsible for renal dysfunction.
Demonstrate that RARalpha (zeige RARA Proteine) was frequently elevated in gastric carcinoma and exerted oncogenic properties via positive feedback loop of IL-1beta/Akt (zeige AKT1 Proteine)/RARalpha (zeige RARA Proteine)/Akt (zeige AKT1 Proteine) signaling.
Icariin inhibits MMP1 (zeige MMP1 Proteine), MMP3 (zeige MMP3 Proteine) and MMP13 (zeige MMP13 Proteine) expression through MAPK (zeige MAPK1 Proteine) pathways in IL1betastimulated SW1353 chondrosarcoma cells
Sesamin showed anti-inflammatory effects in IL-1beta-stimulated chondrocytes by activating Nrf2 (zeige GABPA Proteine) signaling pathway.
This study showed that classical swine fever virus and p7 protein induced IL-1beta secretion and that p7 protein was a short-lived protein degraded by the proteasome.
local expression of IL-1beta and IL-8 (zeige IL8 Proteine) in non-bacterial thrombotic endocarditis, Staphylococcus aureus infective endocarditis, animals with S. aureus sepsis without endocarditis and controls
IL1B regulates expression of IL1R1 (zeige IL1RN Proteine) and IL1RAP (zeige IL1RAP Proteine) and stimulates expression of PTGS1 (zeige PTGS1 Proteine) and PTGS2 (zeige PTGS2 Proteine) that are considered to be the most rate-limiting enzymes for endometrial synthesis of prostaglandins during the peri (zeige PLIN1 Proteine)-implantation period of pregnancy in pigs.
the results presented here strongly suggest IL-1beta as a key molecule guiding tissue remodelling events after myocardial infarction.
The presence of embryos increased endometrial IL1B protein locally, while no differences regarding IL1R1 (zeige IL1RN Proteine) protein and IL1B and IL1R1 (zeige IL1RN Proteine) mRNA were detected.
For the inflammasome-dependent IL-1beta release, bovine monocytes require ATP in addition to a primary stimulus. This IL-1beta release depends on potassium efflux, but, in contrast to human and murine monocytes, does not require calcium influx or generation of reaction oxygen and is independent of the P2X7 receptor (zeige P2RX7 Proteine).
Role of TGF-beta1 (zeige TGFB1 Proteine) and TNF-alpha (zeige TNF Proteine) in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.
Testicular IL-1 alpha (zeige IL1A Proteine) and IL-1 beta concentrations were highest in the early post-natal period; however, IL-1 (zeige IL1A Proteine) bioactivity and IL-6 (zeige IL6 Proteine) concentrations were greatest in the immediate pre-pubertal period.
Data describe the expression of IL-8 (zeige IL8 Proteine), IL-1beta and their respective receptors, CXCR1 (zeige CXCR1 Proteine) and IL-1R1 in bovine theca cells, and suggest that VEGF (zeige VEGFA Proteine) is associated with the IL system in theca cells in ovary.
Genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta may have different roles as regulating PGF (zeige PGF Proteine)(2alpha) and PGE (zeige LIPF Proteine)(2) production during luteal phase.
non-metalloproteinase mechanisms participate in IL-1 (zeige IL1A Proteine)-induced matrix degradation and loss of tissue material properties
dynamic compression stimulates cell proliferation and proteoglycan (zeige Vcan Proteine) synthesis in the presence of IL-1beta and/or inhibitors of the MAPKs and NFkappaB and AP-1 (zeige JUN Proteine) signalling pathways
These results indicate that activation of the intrinsic antistaphylococcal response in bovine endothelial cells (BEC), enhanced by TNF-alpha (zeige TNF Proteine) and IL-1beta, is effective to eliminate S. aureus and S. epidermidis.
the low friction of articular cartilage can be modified by TGF-beta1 (zeige TGFB1 Proteine) and IL-1beta treatment and that the friction coefficient depends on multiple factors, including superficial zone protein localization and surface roughness
Mild heat shock increased the production of inflammatory cytokines, IL-1beta and IL-6 (zeige IL6 Proteine) in rabbit cornea cells.
IL-1beta and TNF-alpha (zeige TNF Proteine) expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta and TNF-alpha (zeige TNF Proteine).
IL-1beta induced a significant reduction in the relative intrinsic activity of GLUT5 and in this decrease are involved NO signal pathways; blockage of D-fructose intestinal uptake by IL-1beta may play an essential role in the pathophysiology of septic shock.
The inhibitory effect of IL-1beta on D-galactose absorption across mucosal side of enterocyte could be mediated by the activation of several kinases and nuclear factor kappa B.
Glucosamine hydrochloride treatment can can partially decrease the expression levels of IL-1 beta and increase the expression levels of TGF-beta 1 (zeige TGFB1 Proteine), which delays the development of osteoarthritis.
In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of IL1B transcripts depending on luteal stage.
results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta,COX-2, and TGFbeta1 (zeige TGFB1 Proteine)
Increased PGE2 production led to reduction in 5-LO (zeige ALOX5 Proteine) products in LPS (zeige IRF6 Proteine)-treated equine whole blood via IL-1b.
Results suggested that chemokine (zeige CCL1 Proteine) expression by cultured equine BECs following exposure to pulmonary hemorrhage conditions may contribute to the development of inflammatory airway disease in horses.
IL-1beta-induced up-regulation of matrix metalloproteinase 13 (zeige MMP13 Proteine) mRNA was blocked by all concentrations of geldanamycin tested
This study examined effects of in vitro exposure to solutions of hay (zeige GTF2H5 Proteine) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
, IL-1 beta
, interleukin-1 beta
, preinterleukin 1 beta
, prointerleukin-1 beta
, Interleukin-1 beta
, precursor interleukin-1beta
, interleukin-1 beta proprotein
, interleukin 1 beta
, lymphocyte proliferation-potentiating factor