anti-Ratte (Rattus) Growth Hormone Receptor Antikörper für ELISA

Recommended Growth Hormone Receptor Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Growth Hormone Receptor (GHR) Antikörper
  • GHBP
  • AA986417
  • GHR/BP
  • GHR
  • ghr
  • growth hormone receptor
  • growth hormone receptor L homeolog
  • GHR
  • Ghr
  • ghr.L
  • ghr
Epitop
AA 1-265
15
10
5
4
4
4
4
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reaktivität
Ratte (Rattus)
76
45
39
17
2
2
1
1
1
Wirt
Kaninchen
78
15
2
Klonalität
Polyklonal
Konjugat
Dieser Growth Hormone Receptor Antikörper ist unkonjugiert
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA
59
30
16
13
11
11
5
5
2
2
2
1
1
1
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Produktnummer ABIN2001605
$ 218.90
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN1585686 IHC ELISA WB Rabbit Middle Region Anmelden zum Anzeigen Polyclonal 0
1 ABIN3181426 ELISA WB Rabbit IgG Internal Region Anmelden zum Anzeigen Polyclonal 0
1 ABIN5633504 ELISA WB Rabbit IgG AA 21-70 Anmelden zum Anzeigen Polyclonal 0
1 ABIN5956831 ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN2692234 ELISA Rabbit IgG AA 1-265 Anmelden zum Anzeigen Polyclonal 0
1 ABIN5956832 ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN6103366 ELISA WB Rabbit IgG N-Term Anmelden zum Anzeigen Polyclonal 0
1 ABIN6045144 ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN6042447 ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN2425987 IHC ELISA Rabbit IgG Anmelden zum Anzeigen Polyclonal 0

General

Antigen Growth Hormone Receptor (GHR) Antikörper
Epitop AA 1-265
(15), (10), (5), (4), (4), (4), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Ratte (Rattus)
(76), (45), (39), (17), (2), (2), (1), (1), (1)
Wirt Kaninchen
(78), (15), (2)
Klonalität
Polyklonal
Konjugat Dieser Growth Hormone Receptor Antikörper ist unkonjugiert
(4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation ELISA
(59), (30), (16), (13), (11), (11), (5), (5), (2), (2), (2), (1), (1), (1)
Pubmed 6 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-Growth Hormone Receptor Antikörper

Target Details Growth Hormone Receptor Anwendungsinformationen Handhabung Referenzen für anti-Growth Hormone Receptor Antikörper (ABIN2001605) Bilder
Spezifität Rat Growth Hormone Receptor / GHR / GHBP
Produktmerkmale Produced in rabbits immunized with purified, recombinant Rat Growth Hormone Receptor / GHR / GHBP (rR Growth Hormone Receptor / GHR / GHBP, ABIN2009068 P16310-1, Met 1-Arg 265,. Growth Hormone Receptor / GHR / GHBP specific IgG was purified by Rat Growth Hormone Receptor / GHR / GHBP affinity chromatography.
Reinigung purified by affinity chromatography
Sterilität 0.2 μm filtered
Immunogen Recombinant Rat Growth Hormone Receptor / GHR / GHBP Protein (ABIN2009068)
Isotyp IgG
Plasmids, Primers & others

Target Details Growth Hormone Receptor

Produktdetails anti-Growth Hormone Receptor Antikörper Anwendungsinformationen Handhabung Referenzen für anti-Growth Hormone Receptor Antikörper (ABIN2001605) Bilder zurück nach oben
Antigen
Andere Bezeichnung GHR (GHR Antibody Abstract)
Hintergrund Growth hormone receptor, also known as GH receptor, Somatotropin receptor and GHR, is a single-pass type I, membrane protein which belongs to the,type I, cytokine receptor family and type 1 subfamily. GHR contains one,fibronectin type-III domain. Growth hormone receptor / GHR is expressed in various tissues with high expression in liver and skeletal muscle. Isoform,4,of GHR is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform,1 expression of GHR in placenta is predominant in chorion and decidua. Isoform,4,is highly expressed in placental villi. Isoform,2,of GHR is expressed in lung, stomach and muscle. Growth hormone receptor / GHR is a receptor for pituitary gland growth hormone. It is involved in regulating postnatal body growth. On ligand binding, it couples to the JAK2 / STAT5 pathway. Isoform,2,of GHR up- regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Defects in GHR are a cause of Laron syndrome (LARS) which is a severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may also be a cause of idiopathic short stature autosomal (ISSA) which is defined by a subnormal rate of growth.
UniProt P16310-1
Pathways NF-kappaB Signalweg, JAK-STAT Signalweg, Response to Growth Hormone Stimulus

Anwendungsinformationen

Produktdetails anti-Growth Hormone Receptor Antikörper Target Details Growth Hormone Receptor Handhabung Referenzen für anti-Growth Hormone Receptor Antikörper (ABIN2001605) Bilder zurück nach oben
Applikations-hinweise ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Rat GHR. The detection limit for Rat GHR is approximately 0.00245 ng/well.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-Growth Hormone Receptor Antikörper Target Details Growth Hormone Receptor Anwendungsinformationen Referenzen für anti-Growth Hormone Receptor Antikörper (ABIN2001605) Bilder zurück nach oben
Format Liquid
Buffer 0.2 μm filtered solution in PBS with 5 % trehalose
Konservierungs-mittel Without preservative
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung 4 °C,-20 °C,-80 °C
Informationen zur Lagerung This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Haltbarkeit 12 months

Referenzen für anti-Growth Hormone Receptor Antikörper (ABIN2001605)

Produktdetails anti-Growth Hormone Receptor Antikörper Target Details Growth Hormone Receptor Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Faustino, Miranda, do Céu Silva, Alves, Picanço, Ferreira, Seixas, Pina, Romão: "Hb Yaoundé [beta134(H12)Val-->Ala] in association with Hb C [beta6(A3)Glu-->Lys] in a Caucasian Portuguese family." in: Hemoglobin, Vol. 28, Issue 3, pp. 229-35, 2004

Jorge, Souza, Arnhold, Mendonca et al.: "The first homozygous mutation (S226I) in the highly-conserved WSXWS-like motif of the GH receptor causing Laron syndrome: supression of GH secretion by GnRH analogue therapy not restored by ..." in: Clinical endocrinology, Vol. 60, Issue 1, pp. 36-40, 2003

Enberg, Luthman, Segnestam, Ritzén, Sundström, Norstedt: "Characterisation of novel missense mutations in the GH receptor gene causing severe growth retardation." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 143, Issue 1, pp. 71-6, 2000

Pantel, Machinis, Sobrier, Duquesnoy, Goossens, Amselem: "Species-specific alternative splice mimicry at the growth hormone receptor locus revealed by the lineage of retroelements during primate evolution." in: The Journal of biological chemistry, Vol. 275, Issue 25, pp. 18664-9, 2000

Sobrier, Dastot, Duquesnoy, Kandemir, Yordam, Goossens, Amselem: "Nine novel growth hormone receptor gene mutations in patients with Laron syndrome." in: The Journal of clinical endocrinology and metabolism, Vol. 82, Issue 2, pp. 435-7, 1997

Leung, Spencer, Cachianes, Hammonds, Collins, Henzel, Barnard, Waters, Wood: "Growth hormone receptor and serum binding protein: purification, cloning and expression." in: Nature, Vol. 330, Issue 6148, pp. 537-43, 1988