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Cow (Bovine) Growth Hormone 1 Protein expressed in - ABIN621622
Wang, Ji, Wang, Chen, Wang, Loor: The preliminary study on the effects of growth hormone and insulin-like growth factor-I on κ-casein synthesis in bovine mammary epithelial cells in vitro. in Journal of animal physiology and animal nutrition 2016
Human Growth Hormone 1 Protein expressed in Escherichia coli (E. coli) - ABIN803848
Mano-Otagiri, Nemoto, Sekino, Yamauchi, Shuto, Sugihara, Oikawa, Shibasaki et al.: Growth hormone-releasing hormone (GHRH) neurons in the arcuate nucleus (Arc) of the hypothalamus are decreased in transgenic rats whose expression of ghrelin receptor is attenuated: Evidence that ... in Endocrinology 2006
GH1 and GHRHR screening revealed eleven variations in 24 (21%) patients with isolated growth hormone deficiency of which, four were novel deleterious, one novel non-pathogenic and six reported changes.
The results suggest that GH regulates energy metabolism directly in myocytes and that UCP2 (zeige UCP2 Proteine) participates in the signal transduction pathway that functions downstream of the GHR (zeige GHR Proteine)/JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine).
These results implicate TIMP3 (zeige TIMP3 Proteine) as a modulator of cell surface GHR (zeige GHR Proteine) abundance and the ability of GH to promote cellular signaling.
Children with GH excess underwent medical treatment with lanreotide and a minimum clinical/biochemical follow up of 2 years is reported. The present study demonstrates that GH excess should be considered as a relative frequent endocrine manifestation in NF1 (zeige NF1 Proteine) patients, similarly to central precocious puberty
Thus, GHRH (zeige GHRH Proteine) analogs of the Miami series powerfully suppress tumor growth, but have only a weak endocrine GH inhibitory activity. The suppression of tumor growth could be induced in part by the downregulation of GHRH (zeige GHRH Proteine) receptors levels.
The intrinsic amyloidogenicity of growth hormone, in the presence of contaminating prion protein (zeige PRNP Proteine) (and perhaps prolactin (zeige PRL Proteine) as well) and amyloid-beta contained in some cadavers' pituitaries, may have led to the observed co-occurring of Creutzfeldt-Jakob disease and Alzheimer's disease.
To our knowledge, c.-223C>T is the first homozygous point mutation in the GH1 promoter that leads to short stature due to idiopathic growth hormone deficiency.
Data show that the recombinant protein produced by the plasmid-free E coli strain was purified and characterized to be human growth hormone (hGH).
Our results suggest that the known protective effect of GH signaling deficiency on neoplastic tissue growth is mediated, at least partially, by regulating p53 (zeige TP53 Proteine) expression
Gene polymorphism of leptin (loci rs7799039) and leptin receptor (loci rs1137101) are correlated with Growth hormone deficiency susceptibility.
These results indicate that up-regulation of GH in the lungs of DJ-1 (zeige PARK7 Proteine) KO mice may enhance the malignancy of B16F10 cells and nodule formation in pulmonary metastasis of melanoma.
Confirmation of the impairment of GH-IGF-1 (zeige IGF1 Proteine) release in hyperphagic MC4R (zeige MC4R Proteine) KO mice suggests a role for insulin (zeige INS Proteine) in regulating both the release of GH, but also in mediating growth during periods of physiologically suppressed GH-IGF-1 (zeige IGF1 Proteine) levels
When charged with hypoxia-ischemia, mutant brains with deleted IGF-1 (zeige IGF1 Proteine) receptor were broadly protected from cell damage, neuroinflammation and cerebral edema.
Thiol-disulfide exchange reactions in hGH and related model peptides were influenced by higher order structure, by the size of the thiol reactant and by an Arg residue adjacent to Cys (zeige DNAJC5 Proteine) in the thiol reactant.
Growth hormone deficient mice exhibited renal hypertrophy in tubular epithelial cells.
observations demonstrate that germline loss of ghrelin-O-acyltransferase alters Growth Hormone release and patterning
alter miR (zeige MLXIP Proteine)-19b concentrations in hematopoietic stem cells (HSCs) and affect HSC (zeige FUT1 Proteine) migration
Moderate elevations in circulating GH and IGF-I (zeige IGF1 Proteine) can directly increase basal insulin (zeige INS Proteine) secretion without impacting beta-cell mass, independent of changes in whole body insulin (zeige INS Proteine) sensitivity and hyperlipidemia.
Acylated ghrelin (zeige GHRL Proteine) is not required for the surge in pituitary growth hormone observed in pregnant mice.
STAT5 (zeige STAT5A Proteine) signaling is increased in the liver in GH-transgenic mice during the growth period, with a balance between positive and negative effectors resulting in accelerated but controlled growth.
bGH mice had increased body weight and decreased percent fat mass. Serum FGF21 (zeige FGF21 Proteine) levels were significantly elevated in bGH mice. Expression of Fgf21 (zeige FGF21 Proteine), Fgfr1 (zeige FGFR1 Proteine), and Klb (zeige KLB Proteine) mRNA in white AT and liver were downregulated or unchanged in bGH mice.
GH/HpaII locus as candidate marker for body weight in cattle rather than MSTN (zeige MSTN Proteine)/DraI.
An SNP GH4.1 in a growth hormone gene was significantly related to a weaning weight.
The association of IGF1 (zeige IGF1 Proteine), GH, and PIT1 (zeige POU1F1 Proteine) markers with growth and reproductive traits were assessed.
The total frequencies for the combined genotypes for the bGH and RORC (zeige RORC Proteine) genes, which provide for superior meat quality and carcass weight, in the populations of Kazakh white-headed cattle
Whereas only moderate structural changes were observed with up-regulation of GH/IGF-I (zeige IGF1 Proteine) axis, disruption of the GH receptor (zeige GHR Proteine) had pronounced effects upon tendon ultra-structure.
this study identifies a biochemical mechanism for the regulation of SCFAs on bovine GH and PRL (zeige PRL Proteine) gene transcription in dairy cow anterior pituitary cells
homozygote genotypes of GH (LL) and beta-LG (AA) were superior compared to heterozygote genotypes, whereas, the heterozygote genotype of Pit-1 (zeige POU1F1 Proteine) gene (AB) was desirable
one GH1 SNP, GH33, was significantly associated with milk protein (zeige CSN2 Proteine) yield in the second lactation. Several GH1 SNPs were significantly associated with fertility.
GH and IGF-I (zeige IGF1 Proteine) genotypes had no substantial effect on productive parameters, though IGF-I (zeige IGF1 Proteine) genotype affected calving-first service interval in primiparous cows. However, the genotypes do alter the endocrine/metabolic profiles of the transition dairy cow.
Data indicate that the dual effects of cortistatin (zeige CORT Proteine) on growth hormone release parallel those of somatostatin (zeige SST Proteine) and are probably mediated by the same receptor(s) and signaling pathway(s) for both peptides.
ghrelin increased growth hormone secretion but not growth hormone synthesis by ovarian follicles
Plasma levels of growth hormone (as well as glucose, insulin (zeige INS Proteine), and leptin (zeige LEP Proteine)) are highly correlated with the duration of winter anovulatory phase.
Expression of PRL (zeige PRL Proteine) and GH in the guinea pig is prominent in the anterior pituitary, similar to known expression patterns of PRL (zeige PRL Proteine) and GH for other species.
Reproductive tests showed that double transgenic males did not differ from non-transgenics. It is possible that GHR (zeige GHR Proteine) excess in the muscle tissues of double transgenics may have contributed to lower circulating GH levels and thus reduced the negative effects of this hormone with respect to reproduction.
that concomitant overexpression of GH and GHR (zeige GHR Proteine) resulted in a strong decrease of the somatotrophic axis intracellular signaling by diminishing its principal transcription factor signal transducer and activator of transcription 5.1 (zeige STAT5B Proteine).
Effects of somatotrophic axis (GH/GHR (zeige GHR Proteine)) double transgenesis on structural and molecular aspects of the zebrafish immune system
The zebrafish gh1 mutant, vizzini, exhibits decreased somatic growth, increased adipose tissue accumulation, and disrupted adipose plasticity after nutrient deprivation.
tbx5 (zeige TBX5 Proteine) knockdown causes a pseudo GH deficiency in zebrafish during early embryonic stages, and supplementation of exogenous GH can partially restore dysmorphogenesis, apoptosis, cell growth inhibition, and abnormal cardiomyogenesis
Findings show similar regulatory growth hormone (GH) and insulin-like growth factor 1 (IGF-1 (zeige IGF1 Proteine)) responses in both Atlantic salmon and rainbow trout.
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation\; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.
pituitary growth hormone
, growth hormone 12
, growth hormone
, growth hormone 1
, neural retina growth hormone
, gnRH receptor
, gonadotropin-releasing hormone receptor
, chorionic somatommamotropin hormone 4
, Pituitary growth hormone
, growth hormone I
, Growth hormone
, growth hormone type a long isoform
, growth hormone type a short isoform
, growth hormone protein
, Growth hormone 1
, growth hormone B3
, growth hormone type 1