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Human EGFR Protein expressed in HEK-293 Cells - ABIN2180999
Fazekas-Singer, Berroterán-Infante, Rami-Mark, Dumanic, Matz, Willmann, Andreae, Singer, Wadsak, Mitterhauser, Jensen-Jarolim: Development of a radiolabeled caninized anti-EGFR antibody for comparative oncology trials. in Oncotarget 2017
Human EGFR Protein expressed in Human Cells - ABIN2001843
Schlessinger: Cell signaling by receptor tyrosine kinases. in Cell 2000
Show all 4 Pubmed References
Human EGFR Protein expressed in Wheat germ - ABIN1352437
Zheng, Zhang, Croucher, Soliman, St-Denis, Pasculescu, Taylor, Tate, Hardy, Colwill, Dai, Bagshaw, Dennis, Gingras, Daly, Pawson: Temporal regulation of EGF signalling networks by the scaffold protein Shc1. in Nature 2013
Human EGFR Protein expressed in HEK-293 Cells - ABIN2181000
Singer, Fazekas, Wang, Weichselbaumer, Matz, Mader, Steinfellner, Meitz, Mechtcheriakova, Sobanov, Willmann, Stockner, Spillner, Kunert, Jensen-Jarolim: Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients. in Molecular cancer therapeutics 2014
Human EGFR Protein expressed in Insect cells (Sf9) - ABIN2720019
Chaudhary, Thamake, Shetty, Vishwanatha: Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies. in British journal of cancer 2014
Human EGFR Protein expressed in HEK-293 Cells - ABIN5674594
Yu, Pegram, Bigner, Chandramohan: Development and validation of a cell-based fluorescent method for measuring antibody affinity. in Journal of immunological methods 2017
Results indicated that most periocular squamous cell carcinomas of horses expressed epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2 (zeige ERBB2 Proteine)).
Graf (zeige ARHGAP26 Proteine) functions to downregulate EGFR signaling.
Data show that EGFR controls the proper formation of brain neuroblasts by regulating the number, survival and proneural gene expression of neuroectodermal progenitor cells which suggest that EGFR signalling is crucially important for patterning and early neurogenesis of the brain.
The activity of Gro (zeige CXCL1 Proteine) is antagonized by EGFR signaling, which inhibits Gro (zeige CXCL1 Proteine)-dependent repression via p-ERK (zeige MAPK1 Proteine) mediated phosphorylation.
These results reveal that ESCRT-0 (ESCRT-0 components stam (zeige STAM Proteine) and hrs)mutants inhibit EGFR signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells.
we find that EGFR regulates the apical determinant Crb and the extracellular matrix regulator Serp, two factors previously known to control tube length. EGFR regulates the organisation of endosomes in which Crb and Serp proteins are loaded
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr) pathway in the lateral epidermis for sustained dpp (zeige TGFb Proteine) expression in the LE. Specifically, we demonstrate that Egfr pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK (zeige MAPK8 Proteine) signaling
Loss of Usp5 (zeige USP5 Proteine) results in upregulation of Notch (zeige NOTCH1 Proteine) signaling and downregulation of RTK signaling by EGF receptor (EGFR) and Sevenless (Sev), leading to impaired photoreceptor development.
These data demonstrate a strong genetic link between dG9a and the EGFR signaling pathway.
Avermectin directly interacts with EGFR and leads to the activation of the EGFR/AKT (zeige AKT1 Proteine)/ERK (zeige MAPK1 Proteine) pathway.
The dorsoventral patterning and EGFR signaling genes play essential roles in correct identity determination and differentiation of lateral glia in the Drosophila nervous system.
Study demonstrated that IGF-I (zeige IGF1 Proteine) can stimulate egfr expression in both follicles cell culture and intact follicles promoting oocyte maturation.
These results indicate that maintenance of Pgrmc1 signaling is required for Egfr expression on zebrafish oocyte cell membranes and for conserving the functions of Egfr in maintaining meiotic arrest through estrogen activation of Gper.
EGFR signaling in vertebrate oocytes can prevent meiotic progression.
the expression of EGFR was mainly restricted to the follicle cells with little expression in the oocytes
mutated plasma EGFR concentration correlated with tumor burden
EGFR mutation status was not a prognostic indicator after surgery in early-stage lung adenocarcinoma
This study suggested that EGFR was an important predictive factor for the prognosis of the post-operative patients with colorectal carcinoma TNM (zeige ODZ1 Proteine) stage I-II, and nm23 (zeige NME1 Proteine) is important for predicting the prognosis of the patients with stage III-IV; it is better that EGFR and nm23 (zeige NME1 Proteine) are as predictor of combination.
EGFR mutations were found in 88% of Sinonasal Inverted Papillomas and 77% of Sinonasal Inverted Papilloma associated Sinonasal Squamous Cell Carcinoma.
advanced non-small-cell lung cancer bearing the EGFR exon 19 insertion or exon 20 insertion is sensitive to EGFR tyrosine kinase (zeige TXK Proteine) inhibitors
optimized an ultrafast laser photolysis hydroxyl radical footprinting method and applied it to study the interaction of EGF (zeige EGF Proteine) and EGFR in live mammalian cells.
This suggests that these compounds may be affected by the EGFR mutation. In conclusion, the present study identified four potential biomarkers in patients with EGFR mutations, using HRM combined with pathway analysis. These results may facilitate the development of novel diagnostic tools for EGFR mutation detection in patients with lung cancer.
thrombin (zeige F2 Proteine) binding to PAR-1 (zeige MARK2 Proteine) receptor activated Gi-protein/c (zeige PROC Proteine)-Src (zeige SRC Proteine)/Pyk2 (zeige PTK2B Proteine)/EGFR/PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine)/p42/p44 (zeige PSMC6 Proteine) MAPK (zeige MAPK3 Proteine) cascade, which in turn elicited AP-1 (zeige FOSB Proteine) activation and ultimately evoked MMP-9 (zeige MMP9 Proteine) expression and cell migration in SK-N-SH cells.
EGFR mutations were confirmed in every case of 16 Asian lung adenocarcinomas (LUAD) regardless of the mutation type.
These results implicate EGFR as a key regulator of RET (zeige RET Proteine) activation in A+AD and suggest that EGFR inhibitors may be therapeutic in patients with A+AD tumors even in the absence of an EGFR or RET (zeige RET Proteine) mutation.
All these findings suggest that EGCG can resist skin senility effectively. And the EGFR with relate of downstream proteins are implicated in the skin aging.
Using a murine model for glioblastoma driven by a single genetic driver, the study suggests differences in EGFR activation contribute to tumor heterogeneity and aggressiveness.
These results suggest that EphA2/Efna1/Egfr genes, linked to a possible control by miR-200a and miR-26b, could be proposed as novel CRC prognostic biomarkers. Moreover, EphA2 could be linked to a mechanism of resistance to cetuximab alternative to KRAS mutations.
These results collectively suggest that sustained activation of Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling in endothelial cells might be a cause of heart failure through suppressing neuregulin-ErbB signaling.
Epidermal growth factor receptor (EGFR) signaling enhances miR (zeige MLXIP Proteine)-29 expression in glioblastoma cells via upregulation of Sterol regulatory element binding protein 1 (zeige SREBF1 Proteine)
YAP (zeige YAP1 Proteine) accumulated in nuclei of mammary glands in ErbB2 (zeige ERBB2 Proteine)/EGFR-transgenic mice, suggesting that EGFR signaling affects YAP (zeige YAP1 Proteine) in vivo similar to cell culture. ErbB2 (zeige ERBB2 Proteine)/EGFR-transgenic mice develop mammary tumors in 7-8 months, but surprisingly, MaSCs from these mice did not form tumors when transplanted into host mice.
Findings suggest that sEGFR might be a biomarker for evaluating insulin (zeige INS Proteine) resistance or a therapeutic target of liraglutide.
Xenoestrogens biphenol-A and nonylphenol stimulate the release of EGFR-ligands by differentially activating ADAM17 (zeige ADAM17 Proteine) or ADAM10 (zeige ADAM10 Proteine).
Data suggest that simultaneous inhibition of mTOR (zeige FRAP1 Proteine) and EGFR or MEK (zeige MDK Proteine) may be more effective in treating colon cancer.
Data indicate alpha-P85 (zeige ECM1 Proteine) Subunit, PI-3K (p85alpha) as a positive regulator of epidermal growth factor receptor (EGFR) expression and cell malignant transformation via nucleolin (zeige NCL Proteine)-dependent mechanism.
this study shows that anemonin may ameliorate LPS (zeige IRF6 Proteine)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR signaling pathways
Syndecan-4 (zeige SDC4 Proteine) mediates porcine respiratory and reproductive syndrome virus entry by interacting with EGFR.
These results indicate that cAMP and oocyte-secreted factors cooperate to promote EGF receptor functionality in developing cumulus oocyte complexes, representing a key component of the acquisition of oocyte developmental competence.
patients experiencing gefitinib dose reduction or short-term treatment interruption due to toxicities did not show inferior survival, compared to those receiving full dose of gefitinib in non-small cell lung cancer patients with EGFR mutation
Report EGFR expression in the normal pancreas.
Injury and activation of purinergic receptors and direct activation of EGFR via EGF (zeige EGF Proteine) induce distinct downstream pathways.
Data suggest that the mechanism of hypoxia-induced increased activation of EGFR kinase is mediated by nNOS (zeige NOS1 Proteine)-derived nitric oxide.
EGFR, VEGFR (zeige KDR Proteine) and FGFR (zeige FGFR2 Proteine) are expressed in porcine oviduct and endometrium during the time of implantation [review]
the restricted presence of the functional full-size receptor to the epithelial layer indicates a specific role during early embryonic development, whereas truncated EGF-R forms may potentially regulate contractions and blood flow in the oviduct
The phase-related expression of EGF (zeige EGF Proteine) and EGFR in the endothelium of the uterine artery and its branches suggest the modulatory effect of EGF (zeige EGF Proteine) and its receptor on the uterine artery and the region supplying these vessels.
Stimulation of bovine oviduct epithelial cell EGFR with EGF (zeige EGF Proteine) (human recombinant EGF (zeige EGF Proteine)) alone or with EGF (zeige EGF Proteine) in postovulatory/follicular phases (not luteal phase) up-regulates phosphorylation of MAPKs; heat blocks effects of EGF (zeige EGF Proteine) on phosphorylation of MAPKs.
Expression of the erbB/HER receptor family in the bovine uterus during the sexual cycle and the relation of this family to serum sex steroids.
Regulation of the sperm EGFR by ouabain leads to initiation of the acrosome reaction.
EGFR may simultaneously activate c-Src (zeige SRC Proteine) and PI3K to amplify the oxytocin signaling to increase the output of PGF (zeige PGF Proteine)(2 alpha) in endometrial epithelial cells.
results indicate that arginase induction depends in part on epidermal growth factor (EGF (zeige EGF Proteine)) receptor activity, and that EGFR inhibitors may attenuate vascular remodeling without affecting nitric oxide release
Data suggest that epidermal growth factor (EGF (zeige EGF Proteine)) and EGF (zeige EGF Proteine) receptors are important paracrine and/or autocrine regulators of spermatogenesis in bovine.
MT1-MMP (zeige MMP14 Proteine) has a role in signaling events mediating EGFR transactivation
possible cooperative role of the EGF (zeige EGF Proteine) and HGF (zeige HGF Proteine) pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow
EGFR is stimulated during capacitation via PKA activation. More activation induces the acrosome reaction, which is induced by GPCR via EGFR transactivation by a signaling pathway involving PKA, SRC & metalloproteinase & effectors PI3K, PLC & PKC.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
, Egf receptor
, drosophila epidermal growth factor receptor homologue
, ellipse torpedo
, epidermal growth factor receptor
, faint little ball
, morphological defects 1
, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
, cell growth inhibiting protein 40
, cell proliferation-inducing protein 61
, proto-oncogene c-ErbB-1
, receptor tyrosine-protein kinase erbB-1
, EGFR-related peptide
, Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, avian erythroblastic leukemia viral (v-erbB) oncogene homolog
, epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, waved 2
, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
, egf receptor
, receptor tyrosine kinase ErbB1