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Human EGFR Protein expressed in HEK-293 Cells - ABIN6253725
Fazekas-Singer, Berroterán-Infante, Rami-Mark, Dumanic, Matz, Willmann, Andreae, Singer, Wadsak, Mitterhauser, Jensen-Jarolim: Development of a radiolabeled caninized anti-EGFR antibody for comparative oncology trials. in Oncotarget 2017
Human EGFR Protein expressed in Human Cells - ABIN2001843
Schlessinger: Cell signaling by receptor tyrosine kinases. in Cell 2000
Show all 4 Pubmed References
Human EGFR Protein expressed in HEK-293 Cells - ABIN2181000
Singer, Fazekas, Wang, Weichselbaumer, Matz, Mader, Steinfellner, Meitz, Mechtcheriakova, Sobanov, Willmann, Stockner, Spillner, Kunert, Jensen-Jarolim: Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients. in Molecular cancer therapeutics 2014
Human EGFR Protein expressed in HEK-293 Cells - ABIN5674594
Yu, Pegram, Bigner, Chandramohan: Development and validation of a cell-based fluorescent method for measuring antibody affinity. in Journal of immunological methods 2017
Human EGFR Protein expressed in Insect cells (Sf9) - ABIN2720019
Chaudhary, Thamake, Shetty, Vishwanatha: Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies. in British journal of cancer 2014
Human EGFR Protein expressed in Wheat germ - ABIN1352437
Zheng, Zhang, Croucher, Soliman, St-Denis, Pasculescu, Taylor, Tate, Hardy, Colwill, Dai, Bagshaw, Dennis, Gingras, Daly, Pawson: Temporal regulation of EGF signalling networks by the scaffold protein Shc1. in Nature 2013
Results indicated that most periocular squamous cell carcinomas of horses expressed epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2 (zeige ERBB2 Proteine)).
stress-dependent EGFR/MAPK promotes gut regeneration via a novel mechanism that operates independently of Insulin/Pi3K/TOR signaling.
EGFR/ARF6 regulation of Hh signaling stimulates oncogenic Ras tumor overgrowth in Drosophila.
Graf (zeige ARHGAP26 Proteine) functions to downregulate EGFR signaling.
Data show that EGFR controls the proper formation of brain neuroblasts by regulating the number, survival and proneural gene expression of neuroectodermal progenitor cells which suggest that EGFR signalling is crucially important for patterning and early neurogenesis of the brain.
The activity of Gro (zeige CXCL1 Proteine) is antagonized by EGFR signaling, which inhibits Gro (zeige CXCL1 Proteine)-dependent repression via p-ERK (zeige MAPK1 Proteine) mediated phosphorylation.
These results reveal that ESCRT-0 (ESCRT-0 components stam (zeige STAM Proteine) and hrs)mutants inhibit EGFR signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells.
we find that EGFR regulates the apical determinant Crb and the extracellular matrix regulator Serp, two factors previously known to control tube length. EGFR regulates the organisation of endosomes in which Crb and Serp proteins are loaded
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr) pathway in the lateral epidermis for sustained dpp (zeige TGFb Proteine) expression in the LE. Specifically, we demonstrate that Egfr pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK (zeige MAPK8 Proteine) signaling
Loss of Usp5 (zeige USP5 Proteine) results in upregulation of Notch (zeige NOTCH1 Proteine) signaling and downregulation of RTK signaling by EGF receptor (EGFR) and Sevenless (Sev), leading to impaired photoreceptor development.
These data demonstrate a strong genetic link between dG9a and the EGFR signaling pathway.
Combination of an EGFR tyrosine kinase inhibitor and a NF-kappaB (zeige NFKB1 Proteine) inhibitor effectively suppressed cetuximab-resistant HNSCC and interfering with the EGFR-LTbeta (zeige LTB Proteine) interaction reverses resistance.
Study demonstrated that IGF-I (zeige IGF1 Proteine) can stimulate egfr expression in both follicles cell culture and intact follicles promoting oocyte maturation.
These results indicate that maintenance of Pgrmc1 (zeige PGRMC1 Proteine) signaling is required for Egfr expression on zebrafish oocyte cell membranes and for conserving the functions of Egfr in maintaining meiotic arrest through estrogen activation of Gper (zeige GPER Proteine).
EGFR signaling in vertebrate oocytes can prevent meiotic progression.
the expression of EGFR was mainly restricted to the follicle cells with little expression in the oocytes
Concurrent mutations, in genes such as CDKN2B (zeige CDKN2B Proteine) or RB1 (zeige RB1 Proteine), were associated with worse clinical outcome in lung adenocarcinoma patients with EGFR active mutations.
ER-alpha36/EGFR signaling loop promotes growth of hepatocellular carcinoma cells
High EGFR expression is associated with colorectal cancer.
High EGFR expression is associated with gefitinib resistance in lung cancer.
High EGFR expression is associated with tumor-node-metastasis in nonsmall cell lung cancer.
Data suggest that Thr264 in TRPV3 (zeige TRPV3 Proteine) is key ERK1 (zeige MAPK3 Proteine) phosphorylation site mediating EGFR-induced sensitization of TRPV3 (zeige TRPV3 Proteine) to stimulate signaling pathways involved in regulating skin homeostasis. (TRPV3 (zeige TRPV3 Proteine) = transient receptor potential cation channel subfamily V member-3 (zeige TRPV3 Proteine); ERK1 (zeige MAPK3 Proteine) = extracellular signal-regulated kinase-1 (zeige MAPK3 Proteine); EGFR = epidermal growth factor receptor)
The EGFR mutation frequency in Middle East and African patients is higher than that shown in white populations but still lower than the frequency reported in Asian populations.
EGFR-containing exosomes derived from cancer cells could favour the development of a liver-like microenvironment promoting liver-specific metastasis.
The results reveal that the EGF (zeige EGF Proteine)-STAT3 (zeige STAT3 Proteine) signaling pathway promotes and maintains colorectal cancer (CRC (zeige CALR Proteine))stemness. In addition, a crosstalk between STAT3 (zeige STAT3 Proteine) and Wnt (zeige WNT2 Proteine) activates the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling pathway, which is also responsible for cancer stemness. Thus, STAT3 (zeige STAT3 Proteine) is a putative therapeutic target for CRC (zeige CALR Proteine) treatment.
This result indicated that T790M mutation is not only associated with EGFR-TKI resistance but also may play a functional role in the malignant progression of lung adenocarcinoma.
The results indicate that EGFR and its activation are critical for YAP (zeige YAP1 Proteine)-mediated suppression of TGF-beta1 (zeige TGFB1 Proteine)-induced apoptosis. This study provides a new understanding of the regulatory mechanism underlying the determination of cell fate in response to TGF-beta1 (zeige TGFB1 Proteine)-mediated simultaneous apoptosis and epithelial mesenchymal transformation.
our findings suggested the concept of the EGFR activated Osteoarthritis (OA) subpopulation and illustrated the mechanism of EGFR signaling in regulating cartilage homeostasis. Gefitinib could be a promising disease-modifying drug for this OA subpopulation treatment.
Cortactin (zeige CTTN Proteine) expression in carcinoma cells and its known involvement in the EGFR pathway suggest a role for this protein as a target for laryngeal squamous cell carcinoma therapy.
results suggest ADAM17/EGFR-driven PLCgamma1 and PKC pathways as important promoters of TG1 expression during terminal keratinocyte differentiation.
Suggest caution for the proposed therapeutic strategy of combined signal transducer and activator of transcription (zeige STAT1 Proteine)/epidermal growth factor receptor inhibition for cancer treatment with respect to cardiotoxity.
Stress-specific p38 MAPK (zeige MAPK14 Proteine) activation is sufficient to drive EGFR endocytosis but not its nuclear translocation.
miR (zeige MLXIP Proteine)-145 can decrease MUC5AC expression by inhibiting EGFR and alleviating airway remodeling. This indicates that miR (zeige MLXIP Proteine)-145 may be used as a molecular predictor for airway remodeling.
To evaluate the role of EGFR signaling in the articular cartilage, we studied a cartilage-specific Egfr-deficient (CKO) mouse model (Col2-Cre EgfrWa5/flox). These mice developed early cartilage degeneration at 6 mo of age. By 2 mo of age, although their gross cartilage morphology appears normal, CKO mice had a drastically reduced number of superficial chondrocytes and decreased lubricant secretion at the surface.
All these findings suggest that EGCG can resist skin senility effectively. And the EGFR with relate of downstream proteins are implicated in the skin aging.
Using a murine model for glioblastoma driven by a single genetic driver, the study suggests differences in EGFR activation contribute to tumor heterogeneity and aggressiveness.
this study shows that anemonin may ameliorate LPS (zeige IRF6 Proteine)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR signaling pathways
Syndecan-4 (zeige SDC4 Proteine) mediates porcine respiratory and reproductive syndrome virus entry by interacting with EGFR.
These results indicate that cAMP and oocyte-secreted factors cooperate to promote EGF receptor functionality in developing cumulus oocyte complexes, representing a key component of the acquisition of oocyte developmental competence.
patients experiencing gefitinib dose reduction or short-term treatment interruption due to toxicities did not show inferior survival, compared to those receiving full dose of gefitinib in non-small cell lung cancer patients with EGFR mutation
Report EGFR expression in the normal pancreas.
Injury and activation of purinergic receptors and direct activation of EGFR via EGF (zeige EGF Proteine) induce distinct downstream pathways.
Data suggest that the mechanism of hypoxia-induced increased activation of EGFR kinase is mediated by nNOS (zeige NOS1 Proteine)-derived nitric oxide.
EGFR, VEGFR (zeige KDR Proteine) and FGFR (zeige FGFR2 Proteine) are expressed in porcine oviduct and endometrium during the time of implantation [review]
the restricted presence of the functional full-size receptor to the epithelial layer indicates a specific role during early embryonic development, whereas truncated EGF-R forms may potentially regulate contractions and blood flow in the oviduct
The phase-related expression of EGF (zeige EGF Proteine) and EGFR in the endothelium of the uterine artery and its branches suggest the modulatory effect of EGF (zeige EGF Proteine) and its receptor on the uterine artery and the region supplying these vessels.
Stimulation of bovine oviduct epithelial cell EGFR with EGF (zeige EGF Proteine) (human recombinant EGF (zeige EGF Proteine)) alone or with EGF (zeige EGF Proteine) in postovulatory/follicular phases (not luteal phase) up-regulates phosphorylation of MAPKs; heat blocks effects of EGF (zeige EGF Proteine) on phosphorylation of MAPKs.
Expression of the erbB/HER receptor family in the bovine uterus during the sexual cycle and the relation of this family to serum sex steroids.
Regulation of the sperm EGFR by ouabain leads to initiation of the acrosome reaction.
EGFR may simultaneously activate c-Src (zeige SRC Proteine) and PI3K to amplify the oxytocin signaling to increase the output of PGF (zeige PGF Proteine)(2 alpha) in endometrial epithelial cells.
results indicate that arginase induction depends in part on epidermal growth factor (EGF (zeige EGF Proteine)) receptor activity, and that EGFR inhibitors may attenuate vascular remodeling without affecting nitric oxide release
Data suggest that epidermal growth factor (EGF (zeige EGF Proteine)) and EGF (zeige EGF Proteine) receptors are important paracrine and/or autocrine regulators of spermatogenesis in bovine.
MT1-MMP (zeige MMP14 Proteine) has a role in signaling events mediating EGFR transactivation
possible cooperative role of the EGF (zeige EGF Proteine) and HGF (zeige HGF Proteine) pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow
EGFR is stimulated during capacitation via PKA activation. More activation induces the acrosome reaction, which is induced by GPCR via EGFR transactivation by a signaling pathway involving PKA, SRC & metalloproteinase & effectors PI3K, PLC & PKC.
These results show that MMP-2 (zeige MMP2 Proteine) activates the EGFR and triggers downstream signaling pathways increasing Reactive Oxygen Species formation and promoting vasoconstriction.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
, Egf receptor
, drosophila epidermal growth factor receptor homologue
, ellipse torpedo
, epidermal growth factor receptor
, faint little ball
, morphological defects 1
, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
, cell growth inhibiting protein 40
, cell proliferation-inducing protein 61
, proto-oncogene c-ErbB-1
, receptor tyrosine-protein kinase erbB-1
, EGFR-related peptide
, Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, avian erythroblastic leukemia viral (v-erbB) oncogene homolog
, epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, waved 2
, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
, egf receptor
, receptor tyrosine kinase ErbB1