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Human EGFR Protein expressed in HEK-293 Cells - ABIN6253725
Fazekas-Singer, Berroterán-Infante, Rami-Mark, Dumanic, Matz, Willmann, Andreae, Singer, Wadsak, Mitterhauser, Jensen-Jarolim: Development of a radiolabeled caninized anti-EGFR antibody for comparative oncology trials. in Oncotarget 2017
Human EGFR Protein expressed in Human Cells - ABIN2001843
Schlessinger: Cell signaling by receptor tyrosine kinases. in Cell 2000
Show all 4 Pubmed References
Human EGFR Protein expressed in Wheat germ - ABIN1352437
Zheng, Zhang, Croucher, Soliman, St-Denis, Pasculescu, Taylor, Tate, Hardy, Colwill, Dai, Bagshaw, Dennis, Gingras, Daly, Pawson: Temporal regulation of EGF signalling networks by the scaffold protein Shc1. in Nature 2013
Human EGFR Protein expressed in HEK-293 Cells - ABIN2181000
Singer, Fazekas, Wang, Weichselbaumer, Matz, Mader, Steinfellner, Meitz, Mechtcheriakova, Sobanov, Willmann, Stockner, Spillner, Kunert, Jensen-Jarolim: Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients. in Molecular cancer therapeutics 2014
Human EGFR Protein expressed in Insect cells (Sf9) - ABIN2720019
Chaudhary, Thamake, Shetty, Vishwanatha: Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies. in British journal of cancer 2014
Human EGFR Protein expressed in HEK-293 Cells - ABIN5674594
Yu, Pegram, Bigner, Chandramohan: Development and validation of a cell-based fluorescent method for measuring antibody affinity. in Journal of immunological methods 2017
Results indicated that most periocular squamous cell carcinomas of horses expressed epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2 (zeige ERBB2 Proteine)).
Graf (zeige ARHGAP26 Proteine) functions to downregulate EGFR signaling.
Data show that EGFR controls the proper formation of brain neuroblasts by regulating the number, survival and proneural gene expression of neuroectodermal progenitor cells which suggest that EGFR signalling is crucially important for patterning and early neurogenesis of the brain.
The activity of Gro (zeige CXCL1 Proteine) is antagonized by EGFR signaling, which inhibits Gro (zeige CXCL1 Proteine)-dependent repression via p-ERK (zeige MAPK1 Proteine) mediated phosphorylation.
These results reveal that ESCRT-0 (ESCRT-0 components stam (zeige STAM Proteine) and hrs)mutants inhibit EGFR signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells.
we find that EGFR regulates the apical determinant Crb and the extracellular matrix regulator Serp, two factors previously known to control tube length. EGFR regulates the organisation of endosomes in which Crb and Serp proteins are loaded
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr) pathway in the lateral epidermis for sustained dpp (zeige TGFb Proteine) expression in the LE. Specifically, we demonstrate that Egfr pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK (zeige MAPK8 Proteine) signaling
Loss of Usp5 (zeige USP5 Proteine) results in upregulation of Notch (zeige NOTCH1 Proteine) signaling and downregulation of RTK signaling by EGF receptor (EGFR) and Sevenless (Sev), leading to impaired photoreceptor development.
These data demonstrate a strong genetic link between dG9a and the EGFR signaling pathway.
Avermectin directly interacts with EGFR and leads to the activation of the EGFR/AKT (zeige AKT1 Proteine)/ERK (zeige MAPK1 Proteine) pathway.
The dorsoventral patterning and EGFR signaling genes play essential roles in correct identity determination and differentiation of lateral glia in the Drosophila nervous system.
Combination of an EGFR tyrosine kinase inhibitor and a NF-kappaB (zeige NFKB1 Proteine) inhibitor effectively suppressed cetuximab-resistant HNSCC and interfering with the EGFR-LTbeta (zeige LTB Proteine) interaction reverses resistance.
Study demonstrated that IGF-I (zeige IGF1 Proteine) can stimulate egfr expression in both follicles cell culture and intact follicles promoting oocyte maturation.
These results indicate that maintenance of Pgrmc1 (zeige PGRMC1 Proteine) signaling is required for Egfr expression on zebrafish oocyte cell membranes and for conserving the functions of Egfr in maintaining meiotic arrest through estrogen activation of Gper (zeige GPER Proteine).
EGFR signaling in vertebrate oocytes can prevent meiotic progression.
the expression of EGFR was mainly restricted to the follicle cells with little expression in the oocytes
qPCR-Invader just needs a common real-time PCR device to accomplish quantification of EGFR mutations, and the fluorescence probes are universal for any target detection
EGFR mutations were associated with the elevated serum carcinoembryonic antigen (zeige CEACAM5 Proteine) levels. Those with the exon 19 deletion have less favourable prognosis than have those with the exon 21 mutation.
Thus, PD-L1 (zeige CD274 Proteine) mRNA expression in EGFR-mutant lung adenocarcinoma was associated with BIM (zeige BCL2L11 Proteine) and VEGFA (zeige VEGFA Proteine) mRNA expression and with shorter PFS after gefitinib therapy.
EGFr seems to be important for both urothelial proliferation and the formation of the three dimensional structure of the epithelium.
EGFR-family phosphosites achieve a trade-off between minimizing off-pathway phosphorylation and maintaining the ability to recruit the diverse complement of effectors required for downstream pathway activation
suggests SIRT1 (zeige SIRT1 Proteine) may serve as a predictor of poor prognosis in esophageal squamous cell carcinoma, and its mediated tumor-promoting role might be associated with the overexpression of EGFR protein in esophageal squamous cell carcinoma
In patients with NSCLC treated with stereotactic radiosurgery for brain metastases, the presence of EGFR mutations is associated with a higher CRR, longer time for distant brain control, and better brain progression-free survival.
Results show that EGFR expression is upregulated in GC (gastric cancer) tumors. Also, EGFR was revealed as a putative target of miR138 and miR204 which bound to the 3'UTR of EGFR mRNA.
Histopathological features, i.e. presence of low-grade areas, may play a role in classifying Glioblastoma (GB) into primary and secondary. EGFR has a pivotal role in gliomagenesis. Combination of p53 (zeige TP53 Proteine) and EGFR alone may not be sufficient to clarify GB into primary and secondary.
Asymmetric heterodimers of HER1/HER2 (zeige ERBB2 Proteine) complexes were analyzed using molecular dynamics simulations. HER2 (zeige ERBB2 Proteine) kinase domain prefers to serve as the receiver rather than the activator. Key binding residues of this dimer complex at N lobe (zeige LTF Proteine) of HER2 (zeige ERBB2 Proteine) is ALA683 and at C lobe of HER1 are GLU914, GLU917, and ASP930.
Cortactin (zeige CTTN Proteine) expression in carcinoma cells and its known involvement in the EGFR pathway suggest a role for this protein as a target for laryngeal squamous cell carcinoma therapy.
results suggest ADAM17/EGFR-driven PLCgamma1 and PKC pathways as important promoters of TG1 expression during terminal keratinocyte differentiation.
Suggest caution for the proposed therapeutic strategy of combined signal transducer and activator of transcription (zeige STAT1 Proteine)/epidermal growth factor receptor inhibition for cancer treatment with respect to cardiotoxity.
Stress-specific p38 MAPK (zeige MAPK14 Proteine) activation is sufficient to drive EGFR endocytosis but not its nuclear translocation.
miR (zeige MLXIP Proteine)-145 can decrease MUC5AC expression by inhibiting EGFR and alleviating airway remodeling. This indicates that miR (zeige MLXIP Proteine)-145 may be used as a molecular predictor for airway remodeling.
To evaluate the role of EGFR signaling in the articular cartilage, we studied a cartilage-specific Egfr-deficient (CKO) mouse model (Col2-Cre EgfrWa5/flox). These mice developed early cartilage degeneration at 6 mo of age. By 2 mo of age, although their gross cartilage morphology appears normal, CKO mice had a drastically reduced number of superficial chondrocytes and decreased lubricant secretion at the surface.
All these findings suggest that EGCG can resist skin senility effectively. And the EGFR with relate of downstream proteins are implicated in the skin aging.
Using a murine model for glioblastoma driven by a single genetic driver, the study suggests differences in EGFR activation contribute to tumor heterogeneity and aggressiveness.
These results suggest that EphA2/Efna1/Egfr genes, linked to a possible control by miR-200a and miR-26b, could be proposed as novel CRC prognostic biomarkers. Moreover, EphA2 could be linked to a mechanism of resistance to cetuximab alternative to KRAS mutations.
These results collectively suggest that sustained activation of Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling in endothelial cells might be a cause of heart failure through suppressing neuregulin-ErbB signaling.
this study shows that anemonin may ameliorate LPS (zeige IRF6 Proteine)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR signaling pathways
Syndecan-4 (zeige SDC4 Proteine) mediates porcine respiratory and reproductive syndrome virus entry by interacting with EGFR.
These results indicate that cAMP and oocyte-secreted factors cooperate to promote EGF receptor functionality in developing cumulus oocyte complexes, representing a key component of the acquisition of oocyte developmental competence.
patients experiencing gefitinib dose reduction or short-term treatment interruption due to toxicities did not show inferior survival, compared to those receiving full dose of gefitinib in non-small cell lung cancer patients with EGFR mutation
Report EGFR expression in the normal pancreas.
Injury and activation of purinergic receptors and direct activation of EGFR via EGF (zeige EGF Proteine) induce distinct downstream pathways.
Data suggest that the mechanism of hypoxia-induced increased activation of EGFR kinase is mediated by nNOS (zeige NOS1 Proteine)-derived nitric oxide.
EGFR, VEGFR (zeige KDR Proteine) and FGFR (zeige FGFR2 Proteine) are expressed in porcine oviduct and endometrium during the time of implantation [review]
the restricted presence of the functional full-size receptor to the epithelial layer indicates a specific role during early embryonic development, whereas truncated EGF-R forms may potentially regulate contractions and blood flow in the oviduct
The phase-related expression of EGF (zeige EGF Proteine) and EGFR in the endothelium of the uterine artery and its branches suggest the modulatory effect of EGF (zeige EGF Proteine) and its receptor on the uterine artery and the region supplying these vessels.
Stimulation of bovine oviduct epithelial cell EGFR with EGF (zeige EGF Proteine) (human recombinant EGF (zeige EGF Proteine)) alone or with EGF (zeige EGF Proteine) in postovulatory/follicular phases (not luteal phase) up-regulates phosphorylation of MAPKs; heat blocks effects of EGF (zeige EGF Proteine) on phosphorylation of MAPKs.
Expression of the erbB/HER receptor family in the bovine uterus during the sexual cycle and the relation of this family to serum sex steroids.
Regulation of the sperm EGFR by ouabain leads to initiation of the acrosome reaction.
EGFR may simultaneously activate c-Src (zeige SRC Proteine) and PI3K to amplify the oxytocin signaling to increase the output of PGF (zeige PGF Proteine)(2 alpha) in endometrial epithelial cells.
results indicate that arginase induction depends in part on epidermal growth factor (EGF (zeige EGF Proteine)) receptor activity, and that EGFR inhibitors may attenuate vascular remodeling without affecting nitric oxide release
Data suggest that epidermal growth factor (EGF (zeige EGF Proteine)) and EGF (zeige EGF Proteine) receptors are important paracrine and/or autocrine regulators of spermatogenesis in bovine.
MT1-MMP (zeige MMP14 Proteine) has a role in signaling events mediating EGFR transactivation
possible cooperative role of the EGF (zeige EGF Proteine) and HGF (zeige HGF Proteine) pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow
EGFR is stimulated during capacitation via PKA activation. More activation induces the acrosome reaction, which is induced by GPCR via EGFR transactivation by a signaling pathway involving PKA, SRC & metalloproteinase & effectors PI3K, PLC & PKC.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
, Egf receptor
, drosophila epidermal growth factor receptor homologue
, ellipse torpedo
, epidermal growth factor receptor
, faint little ball
, morphological defects 1
, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
, cell growth inhibiting protein 40
, cell proliferation-inducing protein 61
, proto-oncogene c-ErbB-1
, receptor tyrosine-protein kinase erbB-1
, EGFR-related peptide
, Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, avian erythroblastic leukemia viral (v-erbB) oncogene homolog
, epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, waved 2
, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
, egf receptor
, receptor tyrosine kinase ErbB1