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Human EGF Protein expressed in Human - ABIN2452189
Cohen, Carpenter: Human epidermal growth factor: isolation and chemical and biological properties. in Proceedings of the National Academy of Sciences of the United States of America 1975
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Human EGF Protein expressed in Escherichia coli (E. coli) - ABIN2452188
Carpenter, Cohen: Epidermal growth factor. in The Journal of biological chemistry 1990
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Human EGF Protein expressed in Escherichia coli (E. coli) - ABIN803887
Rush, Abel, Valadez, Pearson, Cooper: Activation of the Hedgehog pathway in pilocytic astrocytomas. in Neuro-oncology 2010
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Human EGF Protein expressed in Escherichia coli (E. coli) - ABIN593405
An, Gip, Kim, Wu, Park, McVaugh, Schaffer, Bertozzi, Lebrilla: Extensive determination of glycan heterogeneity reveals an unusual abundance of high mannose glycans in enriched plasma membranes of human embryonic stem cells. in Molecular & cellular proteomics : MCP 2012
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Human EGF Protein expressed in Escherichia coli (E. coli) - ABIN2215428
Zhou, Zhang, Jin, Chen, Wu, Li, Yue, Luo, Wang: Prokaryotic expression and refolding of EGFR extracellular domain and generation of phage display human scFv against EGFR. in Biomedicine & pharmacotherapy 2013
Human EGF Protein expressed in Escherichia coli (E. coli) - ABIN987821
Katagiri, Takahashi: Potential relationship between normalization of endometrial epidermal growth factor profile and restoration of fertility in repeat breeder cows. in Animal reproduction science 2006
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Zebrafish scube1 (signal peptide-CUB (complement protein C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor) domain-containing protein 1) is involved in primitive hematopoiesis
EGF is likely a potential paracrine/juxtacrine factor from the oocytes to regulate the function of the follicle cells.
These results suggest that there is an EGF signaling network in the zebrafish ovarian follicle, and the functionality of this network is self-regulated by its own members.
EGF activated Myc and Myc overexpression inhibited miR-26b by recruitment of HDAC3, which in turn induced the expression of EZH2 and promoted the progression of epithelial-mesenchymal transition in human lens epithelial cells
The overarching goal of these studies was to use an unbiased approach to identify proteins that associate with the early endosome in an EGF-dependent manner. Five proteins were detected in endosomes in a ligand-dependent manner: EGFR, RUFY1, STOML2, PTPN23, and CCDC51. Knockdown of RUFY1 or PTPN23 by RNAi indicated that both proteins play a role in EGFR trafficking.
Our results show that the chimeric EGFETA toxin is extremely effective against EGFRpositive cancers and raises the potential to further develop this chimera for use in targeting EGFRpositive tumours resistant to monoclonal antibodies.
These results highlight the potential role of EGF in promoting hepatocellular carcinoma (HCC) metastasis, demonstrate a novel pathway for regulation of FN expression and provide potential targets for HCC prevention and treatment.
The abnormally elevated expression of EGF and TGF-alpha are closely associated with the occurrence and development of chronic pancreatitis and pancreatic cancer
ERRa positively regulated the cell proliferation, migration and invasion of colon cancer cells, and the suppression of ERRa completely reduced the EGF treatment-induced proliferation of colon cancer cells.
EGF significantly upregulated RFPL3 and hTERT protein levels in the nonsmall cell lung cancer cells. RFPL3 and hTERT proteins upregulation by EGF were attenuated by pretreatment with AG1478 and erlotinib. EGF promoted proliferation and inhibited apoptosis; PD98059 decreased RFPL3 and hTERT protein expression; and RFPL3 overexpression increased the expression of hTERT and related MEKpathway proteins.
we have discovered the novel N-72, and it was crucial for EGF-induced migration by targeting MMP2 in Human amnion mesenchymal stem cells (hAMSCs)
The spleen can regulate the functions of hematopoietic stem cells in cirrhotic hypersplenism by regulating EGF signaling.
After HIP1 expression was blocked by siRNAs, EGFR endocytosis was accelerated and this effect was dependent on the EGF concentration. This endocytosis was colocalized with clathrin expression. These findings indicate that the inhibition of HIP1 can accelerate the endocytosis and degradation of EGFR
the present study demonstrated that EGF induced aggressiveness of gastric cancer cells by activating epithelial to mesenchymal transition, which involved the activation of the ERK1/2 pathway and, subsequently, uPAR expression
the EGF system is a mechanosensitizer in bone marrow stromal cells.
EGF counteracts Tat modulation of human endogenous retroviruses of the W family in astrocytes.
FTIR spectra of EGF, unconjugated, post treatment with alpha-lipoic acid, attached to gold nanoparticle, and bound to the bifunctional nanoprobe, showed decreasing disordered structures and turns, and increasing loops, as the synthesis process progressed. There was an overall increase in beta-sheets in final product compared to pure EGF, but this increase was not linear and fluctuated.
EGF-mediated lysosome trafficking, protease secretion, and invasion is regulated by the activity of p38 mitogen activated protein kinase (MAPK) and sodium hydrogen exchangers (NHEs). Interestingly, EGF stimulates anterograde lysosome trafficking through a different mechanism than previously reported for HGF, suggesting that there are redundant signaling pathways that control lysosome positioning
Although the diabetic chronic wounds microenvironment is hostile for local GFs bioavailability, EGF local infiltration circumvented the limitations of its topical application, thus expanding its therapeutic prospect. Our clinical pharmacovigilance and basic studies attest the significance of the GF local infiltration for chronic wounds healing.
these results provide the first evidence for an association between the EGF rs2298999 C/T polymorphism and gout
The increased EGFR expression revealed in patients with seborrheic keratomas (SK)and concomitant (type 2 diabetes mellitus (DM2))is caused by insulin resistance and hyperinsulinemia, in which the dysregulation of insulin signal transmission into the cell leads to changes in EGF synthesis and signaling pathway that regulates cell proliferation and growth.
novel EGFR-NF-kappaB-FOXC1 signaling axis that is critical for BLBC cell function
EGFR pathway gene expression analysis indicated that DeltaNp63 alters EGFR-regulated genes involved in cell adhesion, migration, and angiogenesis. Addition of EGF or neutralizing EGFR antibodies demonstrated that EGFR activation is responsible for DeltaNp63-mediated loss of cellular adhesion
In mice, both EGF and pimecrolimus groups showed less erythema with significantly reduced inflammation and decreased expression of thymic stromal lymphopoietin. EGF relieved S. aureus-induced inflammation and AD-like skin lesions in Nc/Nga mice.
hijacks miR-198/FSTL1 wound-healing switch and steers a two-pronged pathway toward metastasis
These results indicate that Kindlin-1 is essential in EGF-induced re-epithelialization in skin wound healing and provide additional rationale for the clinical application of EGF in the treatment of acute wounds.
concentration of EGF is critical for the switch between hair follicle growth and inhibition, and EGF promotes DP cell proliferation via Notch signaling pathway
EGF promotes FoxM1 expression through the ERK signal pathway
Data indicate that Sonic hedgehog (Shh) stimulate branching morphogenesis (BrM) and induced synthesis of mRNAs for Ptch1 protein, epidermal growth factor (EGF) and receptors of the ErbB receptors ErbB1, ErbB2 and ErbB3.
Either LIF or EGF is needed during development of pre-implantation embryo.
PXR activation stimulates EGF-mediated hepatocyte proliferation in mice, at least in part, through inhibiting FOXO3 from accelerating cell-cycle progression.
Data (including data from studies in knockout mice) suggest that Epab (embryonic poly(A)-binding protein), which is oocyte specific, is required for ability of cumulus cells and granulosa cells to exhibit responsiveness to Egf/Egfr signaling.
modulation of EGF signaling affects in vitro expansion and differentiation of progenitors from embryonic pancreas of both mice and man.
TLR4 blockade prevented TPN-associated intestinal mucosa atrophy by preserving proliferation and preventing apoptosis. This is driven by a reduction in TNF-alpha abundance and increased EGF.
EGF is required for cardiac differentiation of P19CL6 cells through interaction with GATA-4 in a time- and dose-dependent manner.
These data demonstrate that Mcl-1 is essential for mammopoiesis and identify EGF as a critical trigger of Mcl-1 translation to ensure survival of milk-producing alveolar cells.
results indentify EGF signalling as a robust vasculogenic inductive pathway for ATMCs, leading to their transdifferentiation into functional VSMC-like cells.
MEKK1 PHD controls p38 and JNK activation during TGF-beta, EGF and microtubule disruption signalling, but does not affect MAPK responses to hyperosmotic stress.
VEGFR1-mediated signaling plays a critical role in gastric ulcer healing and angiogenesis through enhanced EGF expression on VEGFR1+CXCR4+ cells
The combination of EGF-FGF2 stimulates the proliferation.
IL-6 may act as a new potential cumulus expansion-related transcript, which may be involved in the integration of TrkA and EGF signaling in affecting expansion of cumulus oocyte complexes.
The membrane form of heparin binding EGF-like growth factor (ProHB-EGF) is most likely able to trigger the nuclear translocation of BAG-1 in keeping its level high.
our results indicate that EGF may be able to potentiate AR transactivation that leads to enhancing BCa progression, which may help us to develop a better therapeutic approach to treat BCa via targeting both EGF and AR signaling
Interval between litters and litter size may be linked with EGF polymorphisms in pigs.
10 nM/L EGF was the optimal dose for serum-free culture, which can replace traditional standard serum medium for in vitro expansion of miniature pig bone marrow-derived mesenchymal stem cells.
EGF coordinately activates multiple cell signaling pathways critical to proliferation, migration and survival of trophectoderm cells.
progesterone-induced TACE/ADAM17 leads to production of soluble EGF domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes
The phase-related expression of EGF and EGFR in the endothelium of the uterine artery and its branches suggest the modulatory effect of EGF and its receptor on the uterine artery and the region supplying these vessels.
EGF appears to sensitize epithelial cells to the detrimental effects of IFN-alpha but also helps to restore barrier function in the healing phase.
analysis of EGF in dairy cows reveals increased EGF concentrations for 2-3 days between Days 2 and 5
Data suggest that EGF expression in endometrium varies by species and parity; in Japanese Black cows, EGF expression is consistently high, while in Holstein cows, EGF expression is down-regulated in postpartum period after second calving.
Data suggest that epidermal growth factor receptor B [ErbB] isoforms and their ligands (epidermal growth factor [EGF], amphiregulin [AREG], and neuregulin-1 [NRG1]) are expressed in uteroplacental tissues in mid- and late-phases of pregnancy.
EGF plays a role during bovine placentation.
Data suggest that epidermal growth factor (EGF) and EGF receptors are important paracrine and/or autocrine regulators of spermatogenesis in bovine.
This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.
epidermal growth factor (beta-urogastrone)
, pro-epidermal growth factor
, Pro-epidermal growth factor precursor (EGF)