anti-Maus CD40 Antikörper für Blocking Reagent

Recommended CD40 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) Antikörper
  • Bp50
  • CDW40
  • TNFRSF5
  • p50
  • AI326936
  • GP39
  • HIGM1
  • IGM
  • IMD3
  • T-BAM
  • TRAP
  • Tnfrsf5
  • TNFSF5
  • CD40 molecule
  • CD40 antigen
  • CD40
  • Cd40
Reaktivität
Maus, Ratte (Rattus)
636
310
66
20
13
10
9
6
4
3
2
1
1
1
1
1
Wirt
Armenischer Hamster
496
214
166
22
6
3
Klonalität
Monoklonal
Konjugat
Dieser CD40 Antikörper ist unkonjugiert
86
84
48
36
24
21
17
15
13
13
9
9
9
9
9
9
9
8
7
7
7
7
6
6
5
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Blocking Reagent (BR), Flow Cytometry (FACS)
576
243
214
188
108
102
95
64
50
33
19
15
13
13
9
6
6
4
3
3
2
2
2
2
1
1
1
1
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Mehr erfahren

Produktnummer ABIN1176841
Preis und Verfügbarkeit auf Anfrage.
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN2658979 BR FACS IP IHC PE-Cy5 Rat IgG2a kappa Anmelden zum Anzeigen 3-23 3
1 ABIN2658980 BR FACS IP IHC PE-Cy5 Rat IgG2a kappa Anmelden zum Anzeigen 3-23 3

General

Antigen CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) Antikörper
Reaktivität Maus, Ratte (Rattus)
(636), (310), (66), (20), (13), (10), (9), (6), (4), (3), (2), (1), (1), (1), (1), (1)
Wirt Armenischer Hamster
(496), (214), (166), (22), (6), (3)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser CD40 Antikörper ist unkonjugiert
(86), (84), (48), (36), (24), (21), (17), (15), (13), (13), (9), (9), (9), (9), (9), (9), (9), (8), (7), (7), (7), (7), (6), (6), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Blocking Reagent (BR), Flow Cytometry (FACS)
(576), (243), (214), (188), (108), (102), (95), (64), (50), (33), (19), (15), (13), (13), (9), (6), (6), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 15 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-CD40 Antikörper

Target Details CD40 Anwendungsinformationen Handhabung Referenzen für anti-CD40 Antikörper (ABIN1176841) Bilder
Marke BD Pharmingen™
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Sterilität 0.2 μm filtered
Endotoxin-Niveau Endotoxin level is ≤ 0.01 ng/μg of protein.
Immunogen (BALB/c x NZB)F1 mouse-derived lymphoma WEHI-231
Klon HM40-3
Isotyp IgM, kappa

Target Details CD40

Produktdetails anti-CD40 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-CD40 Antikörper (ABIN1176841) Bilder zurück nach oben
Antigen
Andere Bezeichnung CD40 (CD40 Antibody Abstract)
Hintergrund The HM40-3 antibody reacts with CD40, a 40-50-kDa glycoprotein expressed on B lymphocytes and other antigen-presenting cells. The CD40 molecule has a central role in B-cell growth and differentiation. Furthermore, interactions of CD40 with its ligand, CD154, are involved in the initiation and effector stages of cell-mediated immune responses. CD40 may be involved in the triggering of NK cells and NK-T cells. Soluble HM40-3 antibody stimulates splenic and peritoneal B cells to proliferate in vitro. This antibody also induces spleen B cells to express the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). HM40-3 mAb has been demonstrated to inhibit the binding of soluble CD154 (gp39, CD40 Ligand) to soluble CD40 and to cell-surface CD40. This hamster mAb to a mouse leukocyte antigen has been observed to cross-react with similar populations of Lewis, Sprague-Dawley, and LOU16 rat leukocytes.
Pathways NF-kappaB Signalweg, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response

Anwendungsinformationen

Produktdetails anti-CD40 Antikörper Target Details CD40 Handhabung Referenzen für anti-CD40 Antikörper (ABIN1176841) Bilder zurück nach oben
Applikations-hinweise For immunohistochemical staining of mouse tissue, we recommend the use of purified anti-mouse CD40 mAb 3/23 in our special formulation for immunohistochemistry, Cat. No. 550285. 553721 Note: This product may appear to contain aggregation and/or precipitation of the IgM antibody. Investigators are advised to briefly spin down any particulate matter.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-CD40 Antikörper Target Details CD40 Anwendungsinformationen Referenzen für anti-CD40 Antikörper (ABIN1176841) Bilder zurück nach oben
Format Liquid
Konzentration 1.0 mg/mL
Buffer No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm filtered.
Konservierungs-mittel Azide free
Lagerung 4 °C
Informationen zur Lagerung This preparation contains no preservatives, thus it should be handled under aseptic conditions. Store undiluted at 4°C.

Referenzen für anti-CD40 Antikörper (ABIN1176841)

Produktdetails anti-CD40 Antikörper Target Details CD40 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Turner, Rakhmilevich, Burdelya, Neal, Imboden, Sondel, Yu: "Anti-CD40 antibody induces antitumor and antimetastatic effects: the role of NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 89-94, 2001

Trinité, Voisine, Yagita, Josien: "A subset of cytolytic dendritic cells in rat." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 8, pp. 4202-8, 2000

Leifeld, Trautwein, Dumoulin, Manns, Sauerbruch, Spengler: "Enhanced expression of CD80 (B7-1), CD86 (B7-2), and CD40 and their ligands CD28 and CD154 in fulminant hepatic failure." in: The American journal of pathology, Vol. 154, Issue 6, pp. 1711-20, 1999

Akiba, Oshima, Takeda, Atsuta, Nakano, Nakajima, Nohara, Yagita, Okumura: "CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 12, pp. 7058-66, 1999

Tomura, Yu, Ahn, Yamashita, Yang, Ono, Hamaoka, Kawano, Taniguchi, Koezuka, Fujiwara: "A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 1, pp. 93-101, 1999

Grewal, Flavell: "CD40 and CD154 in cell-mediated immunity." in: Annual review of immunology, Vol. 16, pp. 111-35, 1998

Ridge, Di Rosa, Matzinger: "A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell." in: Nature, Vol. 393, Issue 6684, pp. 474-8, 1998

Kaneko, Hirose, Abe, Yagita, Okumura, Shirai: "CD40-mediated stimulation of B1 and B2 cells: implication in autoantibody production in murine lupus." in: European journal of immunology, Vol. 26, Issue 12, pp. 3061-5, 1997

Kawano, Cui, Koezuka, Toura, Kaneko, Motoki, Ueno, Nakagawa, Sato, Kondo, Koseki, Taniguchi: "CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides." in: Science (New York, N.Y.), Vol. 278, Issue 5343, pp. 1626-9, 1997

Kashiwada, Kaneko, Yagita, Okumura, Takemori: "Activation of mitogen-activated protein kinases via CD40 is distinct from that stimulated by surface IgM on B cells." in: European journal of immunology, Vol. 26, Issue 7, pp. 1451-8, 1996

Inaba, Inaba, Fukuba, Mori, Haruna, Doi, Adachi, Iwai, Hosaka, Hisha: "Activation of thymic B cells by signals of CD40 molecules plus interleukin-10." in: European journal of immunology, Vol. 25, Issue 5, pp. 1244-8, 1995

Foy, Laman, Ledbetter, Aruffo, Claassen, Noelle: "gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory." in: The Journal of experimental medicine, Vol. 180, Issue 1, pp. 157-63, 1994

Inaba, Witmer-Pack, Inaba, Hathcock, Sakuta, Azuma, Yagita, Okumura, Linsley, Ikehara, Muramatsu, Hodes, Steinman: "The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro." in: The Journal of experimental medicine, Vol. 180, Issue 5, pp. 1849-60, 1994

Parry, Hasbold, Holman, Klaus: "Hypercross-linking surface IgM or IgD receptors on mature B cells induces apoptosis that is reversed by costimulation with IL-4 and anti-CD40." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 152, Issue 6, pp. 2821-9, 1994

Noelle, Ledbetter, Aruffo: "CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation." in: Immunology today, Vol. 13, Issue 11, pp. 431-3, 1993