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The results suggest that SH3GL2 suppresses migration and invasion behaviors of glioma cells through negatively regulating STAT3 (zeige STAT3 Proteine)/MMP2 (zeige MMP2 Proteine) signaling.
Alix acts in concert with endophilin A to promote clathrin-independent endocytosis of cholera toxin and to regulate cell migration.
This study identified a new mitochondria reprogramming pathway influencing breast cancer progression through SH3GL2 and MFN2 (zeige MFN2 Proteine). These proteins were frequently lost in breast cancer, which was traceable in the circulating exosomes.
Endophilin-1 was a direct and functional downstream target of miR (zeige MLXIP Proteine)-107.
Methylation status of SH3GL2 gene was associated with the TNM (zeige ODZ1 Proteine) staging and HPV infection status of vulvar squamous cell carcinoma.
Endophilin-1 positively regulated blood-brain barrier permeability via the EGFR (zeige EGFR Proteine)-JNK (zeige MAPK8 Proteine) signaling pathway in hCMEC/D3 cells, which would provide an experimental basis for further research on endophilin-1 mediated the opening of blood-brain barrier .
these results reveal a novel function of postsynaptic endophilin A1 in spine morphogenesis, stabilization and synaptic function through the regulation of p140Cap (zeige SRCIN1 Proteine)
Data indicate that the presence of the susceptible G allele in SNP rs1049430 is associated with the inactivation of SH3-domain GRB2-like 2 protein (SH3GL2) and could be used as a prognostic marker of head and neck squamous cell carcinoma (HNSCC).
study described that endophilin-1 is expressed in hCMEC/D3 cells where it regulates the permeability of blood-brain barrier by altering the expression of ZO-1 and occludin via the EGFR-ERK1/2 pathway
miR (zeige MLXIP Proteine)-330 negatively regulated the expression of SH3GL2 in GSCs, which promoted the oncogenic progression of GSCs through activating ERK (zeige EPHB2 Proteine) and PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) signaling pathways.
Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase (zeige MUL1 Proteine) FBXO32/atrogin-1 (zeige FBXO32 Proteine) and its transcription factor FOXO3A (zeige FOXO3 Proteine).
retrolinkin is a binding partner of endophilin A1 and that both proteins are required for BDNF (zeige BDNF Proteine)-induced dendrite outgrowth
Data report that the parkin ubiquitin-like domain binds SH3 domains from endocytic BAR proteins such as endophilin-A with an affinity comparable to proline-rich domains from well-established SH3 partners.
Tip-to-tip interactions between the BAR domains in a trigonal crystal form of Snx9 (zeige SNX9 Proteine)(PX-BAR) reminiscent of functionally important interactions described for F-BAR domains.
Results sugest that reduced or defective OPHN1 (zeige OPHN1 Proteine) signaling impairs synaptic vesicle cycling at hippocampal synapses.
interacts with synaptojanin and dynamin I\; may be involved in synaptic vesicle recycling
Endophilin A1 BAR domain
, SH3 domain protein 2A
, SH3 domain-containing GRB2-like protein 2
, bA335L15.1 (SH3-domain GRB2-like 2)
, endophilin A1
, endophilin I
, SH3 domain-containing GRB2-like protein 1