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RhoGEF plays essential role in ciliated epithelia during vertebrate development.
Agonist-induced Ca2 (zeige CA2 Proteine)+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
SNPs associated with type 2 diabetes and obesity may also increase the risk of developing gestational diabetes mellitus (GDM) in the Chinese population. Among these SNPs, we report for the first time that rs945508 in ARHGEF11, rs10804591 in PLXND1 (zeige PLXND1 Proteine) and rs10245353 in NFE2L3 (zeige NFE2L3 Proteine) were associated with GDM.
PAK4 (zeige PAK4 Proteine) (but not PAK1 (zeige PAK1 Proteine)) mediates invadopodia maturation during melanoma invasion likely via inhibition of PDZ-RhoGEF.
Data show that endothelin A receptor (zeige EDNRA Proteine) drives invadopodia function by direct interaction of beta-arrestin-1 (zeige ARRB1 Proteine) (beta-arr1 (zeige ARRB1 Proteine)) with Rho guanine nucleotide exchange factor (GEF) 11 protein (PDZ-RhoGEF).
Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associated RhoGEF (LARG (zeige ARHGEF12 Proteine)), use their PDZ domains to bind class B plexins and play critical roles in signaling.
Results provide new evidence that ARHGEF11 may constitute a risk factor for schizophrenia
Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs).
analysis of molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF
Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS (zeige PITX2 Proteine))-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG (zeige ARHGEF12 Proteine)).
The R1467H polymorphism of ARHGEF11 gene may contribute to susceptibility to type 2 diabetes mellitus and insulin (zeige INS Proteine) resistance in a Chinese population.
These results demonstrate that PDZ-RhoGEF acts as a key determinant of mammalian metabolism and obesity-associated pathologies.
PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.
results suggest that ARHGEF11 mediates RhoA (zeige RHOA Proteine)-myosin light chain signaling pathways at cell-cell junctions, functioning in cooperation with ZO-1 (zeige TJP1 Proteine)
PDZ-RhoGEF interacts directly with p21-activated kinase 4 (zeige PAK4 Proteine) to negatively regulate the activation of Rho
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.
, rho guanine nucleotide exchange factor 11
, Rho guanine nucleotide exchange factor (GEF) 11
, rho guanine nucleotide exchange factor 11-like
, Rho guanine exchange factor (GEF) 11
, RhoA-specific guanine nucleotide exchange factor
, RhoGEF glutamate transport modulator
, glutamate transporter EAAT4-associated protein 48
, RhoGEF glutamate transport modulator GTRAP48
, glutamate transporter EAAT4 associated protein 48