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sortilin negatively regulates TGF-beta (zeige TGFB1 Proteine) signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway
regulator of EGFR (zeige EGFR Proteine) intracellular trafficking that promotes receptor internalization and limits signaling, which in turn impacts tumor growth
Results provide evidence that progranulin (zeige GRN Proteine) destabilizes sortilin via ubiquitination and lysosomal degradation to override the negative modulatory functions of sortilin thereby assuring the sustainable pro-tumorigenic actions of progranulin (zeige GRN Proteine) in castration-resistant prostate cancer.
we report that sortilin also plays a role in tau prion (zeige PRNP Proteine) replication and may thus represent an exciting target for therapeutic intervention in tau-related diseases.
The SNP rs17646665, located in a non-coding region of the SORT1 gene, remained significantly associated with decreased risk of Alzheimer's disease after multiple testing (pc = 0.0061). In addition, other SNPs were found to be nominally associated with risk of Alzheimer's disease, as well as altered cognitive function and the CSF (zeige CSF2 Proteine) biomarker Abeta42, but these associations did not survive correction for multiple testing.
Sortilin was overexpressed in thyroid cancers compared with benign thyroid tissues
Authors provide evidence that Mn-induced exit of GPP130 (zeige GOLIM4 Proteine) from the trans-Golgi network (TGN (zeige TG Proteine)) toward lysosomes is mediated by the sorting receptor sortilin interacting with the lumenal stem domain of GPP130 (zeige GOLIM4 Proteine).
The longitudinal quantification of the serum sortilin-derived propeptide concentration could assist psychiatrists in the diagnosis of antidepressant response efficacy
Both circulating SORT1 and PCSK9 (zeige PCSK9 Proteine) levels are elevated in coronary artery disease patients.
Soluble sortilin exists in cerebrospinal fluid (CSF (zeige CSF2 Proteine)) in ten-fold molar excess compared to progranulin (zeige GRN Proteine) and observed a highly significant positive correlation between soluble sortilin and progranulin (zeige GRN Proteine) levels in CSF (zeige CSF2 Proteine) but not in plasma. The carriers of the minor allele of SNP rs646776 in SORT1 encoding sortilin displayed significantly increased soluble sortilin and reduced progranulin (zeige GRN Proteine) specifically in plasma but not in CSF (zeige CSF2 Proteine).
SORT1 single nucleotide polymorphism and it's association with LDL cholesterol level and risk of coronary heart disease in Pakistani population
Altogether, sortilin defines a pathway required for optimal intracellular mycobacteria control and lung inflammation in vivo.
findings provide insights into the posttranslational regulation of cytokine production through the posttranscriptional control of sortilin expression by TLR signals.
We showed that expression levels for NTS (zeige NTS Proteine) and NTSR1 (zeige NTSR1 Proteine) varied, that NTSR2 (zeige NTSR2 Proteine) expression was not detectable and that NTSR3 was consistently expressed in all CRC cell lines examined.
our findings indicate that sortilin is a beneficial protein for the reduction of amyloid pathology in APP (zeige APP Proteine)/PS1 (zeige PSEN1 Proteine) mice by promoting APP (zeige APP Proteine) degradation
we identify interferon-gamma (IFN-gamma (zeige IFNG Proteine)) as the key inflammatory mediator controlling sortilin-1 levels
Data suggest that sortilin expression in both gastrocnemius and extensor digitorum longus muscle is down-regulated by 17-18h of fasting/food deprivation; pathological levels of high blood glucose, as in streptozotocin-induced diabetes, do not alter sortilin expression in skeletal muscle; sortilin expression is elevated during differentiation of myocyte cell line or in presence of high concentration of glucose.
Shh (zeige SHH Proteine) and Sort1 can interact at the level of the Golgi and that Sort1 directs Shh (zeige SHH Proteine) away from the pathways that promote its secretion.
By contrast, treatment with dexamethasone, which also induced insulin (zeige INS Proteine) resistance, was without effect on sortilin expression and PE production. As a putative bioactive peptide, we have evaluated its autocrine effect by the use of spadin on 3T3-L1 adipocytes by performing glucose uptake and signalling experiments. Any effect was measured on adipocytes indicating that the use of spadin as an antidepressant would have no side
Sortilin 1 (Sort1) knockout (KO) does not affect Western diet-induced obesity nor adipose fatty acid and ceramide concentrations.
sortilin regulates cholestatic liver damage and fibrosis via effects on both aSMase (zeige SMPD1 Proteine) activity and serum IL-6 (zeige IL6 Proteine).
This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes\; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p\; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins.
, 100 kDa NT receptor
, glycoprotein 95
, neurotensin receptor 3
, glycoprotein 110