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anti-Human MAGI2 Antikörper:
anti-Mouse (Murine) MAGI2 Antikörper:
anti-Rat (Rattus) MAGI2 Antikörper:
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Dog (Canine) Polyclonal MAGI2 Primary Antibody für WB - ABIN2788791
Doukhanine, Gavino, Haines, Almazan, Richard: The QKI-6 RNA binding protein regulates actin-interacting protein-1 mRNA stability during oligodendrocyte differentiation. in Molecular biology of the cell 2010
MAGI-2 immunoreactivity is elevated in prostate cancer and high-grade prostatic intraepithelial neoplasia compared with normal tissue, suggesting that MAGI-2 may contribute to prostate carcinogenesis.
Immunohistochemistry in kidney sections from these patients revealed that mutations resulted in lack of or diminished podocyte MAGI2 expression. Our data support the finding that mutations in the MAGI2 gene are causal for congenital steroid-resistant nephrotic syndrome
MAGI-2 could represent a useful adjunct for diagnosis of prostatic adenocarcinoma
The expression of MAGI2 mRNA was significantly down-regulated in PC3 (zeige PCSK1 Antikörper), LNCaP and DU-145 PCa (zeige FLVCR1 Antikörper) cell lines.
MAGI2, SERPINE2 (zeige SERPINE2 Antikörper), and NT5C3B expression levels are associated with airway wall thickening and additionally with bronchial inflammation, emphysema, and lung function, respectively, all features of chronic obstructive pulmonary disease.
Data show that the miR (zeige MLXIP Antikörper)-134/487b/655 cluster regulates TGF-beta1 (zeige TGFB1 Antikörper)-induced epithelial-mesenchymal transition and affected the resistance to gefitinib by directly targeting membrane-associated guanylate kinase (zeige GUK1 Antikörper), WW, and PDZ domain-containing protein 2 (zeige PDZD2 Antikörper) (MAGI2).
In Usher syndrome 1G, mutations in SANS (zeige USH1G Antikörper) eliminate Magi2 binding and thereby deregulate endocytosis, lead to defective ciliary transport modules and ultimately disrupt photoreceptor cell function inducing retinal degeneration.
MAGI2 enhances the sensitivity of BEL-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing PTEN stability.
Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients.
Results presented herein provide further evidence for a role of MAGI2 in bipolar affective disorder and schizophrenia etiology.
In summary,MAGI-2 and Fyn (zeige FYN Antikörper) protect dendrin fromNedd4-2-mediated ubiquitination and from nuclear translocation, thereby maintaining the physiologic homeostasis of podocytes, and the lack of MAGI-2 in podocytes results in FSGS (zeige ACTN4 Antikörper).
Magi2 is an essential component of the slit diaphragm complex that is required for nephrin (zeige NPHS1 Antikörper) localization and foot process formation.
MAGI-2 has a critical role in maintaining the functional structure of the slit diaphragm and this molecule has an essential role in the functioning of the kidney filtration barrier.
We showed the expression patterns of MAGI-2 in detail in adult mice. Significant Venus expression was detected in various regions of the brain, also detected in glomeruli of the kidney. We found the novel expression of MAGI-2 in the testis.
MAGI-2 is required for the integrity of the kidney filter and podocyte survival.
elevation of S-SCAM expression in the excitatory neurons of forebrain was sufficient to induce an schizophrenia-like phenotype in mice.
In Usher syndrome 1G, mutations in SANS eliminate Magi2 binding and thereby deregulate endocytosis, lead to defective ciliary transport modules and ultimately disrupt photoreceptor cell function inducing retinal degeneration.
ARIP1 and ARIP2 (zeige SYNJ2BP Antikörper) are co-expressed in some nerve cells and their biological activities are distinct.
Two subsynaptic domains, one containing IgSF9b for synaptic adhesion and the other containing gephyrin (zeige GPHN Antikörper) and GABAA (zeige GABRg1 Antikörper) receptors for synaptic transmission, are interconnected through S-SCAM and neuroligin 2 (zeige NLGN2 Antikörper).
ARIP1 is a key molecule for the regulation of the action of activin (zeige Actbeta Antikörper) in neurones, and also that decreased ARIP1 expression in the lesioned brain may be beneficial to the neurotrophic and neuroprotective roles of activin A (zeige INHBA Antikörper) in recovery after brain injury.
The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.
membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
, membrane associated guanylate kinase, WW and PDZ domain containing 2
, Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
, membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2-like
, activin receptor interacting protein 1
, atrophin-1-interacting protein 1
, atrophin-1-interacting protein A
, membrane-associated guanylate kinase inverted 2
, activin receptor-interacting protein 1
, synaptic-scaffolding molecule