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anti-Human HDAC3 Antikörper:
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Human Polyclonal HDAC3 Primary Antibody für ChIP, ICC - ABIN151195
Cress, Seto: Histone deacetylases, transcriptional control, and cancer. in Journal of cellular physiology 2000
Show all 9 Pubmed References
Human Polyclonal HDAC3 Primary Antibody für ICC, IF - ABIN152952
Fischle, Emiliani, Hendzel, Nagase, Nomura, Voelter, Verdin: A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p. in The Journal of biological chemistry 1999
Show all 14 Pubmed References
Human Monoclonal HDAC3 Primary Antibody für ICC, ELISA - ABIN969188
Grégoire, Xiao, Nie, Zhang, Xu, Li, Wong, Seto, Yang: Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. in Molecular and cellular biology 2007
Show all 3 Pubmed References
Human Monoclonal HDAC3 Primary Antibody für IHC, ELISA - ABIN969189
Spurling, Godman, Noonan, Rasmussen, Rosenberg, Giardina: HDAC3 overexpression and colon cancer cell proliferation and differentiation. in Molecular carcinogenesis 2008
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Human Polyclonal HDAC3 Primary Antibody für ICC, IF - ABIN256669
Inoue, Mai, Dyer, Cohen: Inhibition of histone deacetylase class I but not class II is critical for the sensitization of leukemic cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. in Cancer research 2006
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Human Polyclonal HDAC3 Primary Antibody für WB - ABIN2668681
Imbriano, Gurtner, Cocchiarella, Di Agostino, Basile, Gostissa, Dobbelstein, Del Sal, Piaggio, Mantovani: Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters. in Molecular and cellular biology 2005
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Chicken Polyclonal HDAC3 Primary Antibody für IHC, WB - ABIN223297
Mao, Hou, Cao, Wang, Li, Chen, Fei, Hurren, Gronda, Wu, Trudel, Schimmer: The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: in vitro and in silico evidence. in Molecular pharmacology 2011
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Dog (Canine) Monoclonal HDAC3 Primary Antibody für IF, WB - ABIN968379
Emiliani, Fischle, Van Lint, Al-Abed, Verdin: Characterization of a human RPD3 ortholog, HDAC3. in Proceedings of the National Academy of Sciences of the United States of America 1998
Human Monoclonal HDAC3 Primary Antibody für IP, WB - ABIN2668680
Mueller, Breuer, Schmitt, Walter, Evert, Wüllner: CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3. in Human molecular genetics 2009
Human Monoclonal HDAC3 Primary Antibody für ELISA, IHC - ABIN2869346
Brodie, Li, El-Kommos, Kang, Ramalingam, Behera, Gandhi, Kowalski, Sica, Khuri, Vertino, Brandes: Class I HDACs are mediators of smoke carcinogen-induced stabilization of DNMT1 and serve as promising targets for chemoprevention of lung cancer. in Cancer prevention research (Philadelphia, Pa.) 2014
Brm (zeige SMARCA2 Antikörper)-HDAC3-Erm (zeige MSN Antikörper) repressor complex suppresses dedifferentiation of intermediate neural progenitors back into type II neuroblasts.
Hdac3 served as an important regulator of the PI3K pathway and revealed a novel link between histone acetylation and growth control.
Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X tremor ataxia syndrome.
) DHDAC1 (zeige HDAC1 Antikörper) and -3 have distinct functions in the control of gene expression
Mutant larvae display small imaginal discs, which result from abnormally elevated levels of apoptosis. This cell death occurs as a cell-autonomous response to HDAC3 loss and is accompanied by increased expression of the pro-apoptotic gene, hid.
HDAC3-mediated p53 (zeige TP53 Antikörper) acetylation and oligomerization is induced by apoptosis caused by delphinidin in prostate cancer cells
Knockdown of either Xist or SPEN (zeige SPEN Antikörper) expression in breast cancer cells suppressed the expression of PHLPP1 (zeige PHLPP1 Antikörper), a phosphatase in AKT (zeige AKT1 Antikörper) dephosphorylation, and was correlated with increased HDAC3 recruitment to the PHLPP1 (zeige PHLPP1 Antikörper) promoter.
Data show that BRCA2 was required for HDAC2/3 association with acetylated BubR1 in nocodazole (Noc)-arrested cells.
Data show that the nuclear HDAC3 and cytoplasmic CDH1 (zeige CDH1 Antikörper) have independent prognostic value in pancreatic cancer and provide targets for prognostic therapeutics.
HDAC3 uniquely primes Ucp1 (zeige UCP1 Antikörper) and the thermogenic transcriptional program to maintain a critical capacity for thermogenesis in brown adipose tissue that can be rapidly engaged upon exposure to dangerously cold temperature
The low expression of HDAC3 and overexpession of inflammatory cytokines (IL-18 (zeige IL18 Antikörper), IL-12 (zeige IL12A Antikörper) and TNF-alpha (zeige TNF Antikörper)) in intrahepatic cholestasis of pregnancy may be involved in liver cell apoptosis and in the pathophysiology of the disease.
SNP rs14251 was found to be significant (and rs2530223 to be nominally significantly associated with the increasing risk of SCZ susceptibility in Han Chinese individuals, suggesting this gene as a potential genetic modifier for SCZ development.
Inhibition of HDAC3 with targeted therapy could benefit treatment of the diseases associated with sGCbeta1 down-regulation and/or deficiency such as cancer and several vascular-related diseases.
that histone deacetylase 3 interaction with MeCP2 positively regulates a subset of neuronal genes through FOXO (zeige FOXO3 Antikörper) deacetylation, and disruption of HDAC3 contributes to cognitive and social impairment
provide evidence to show that CBX4 (zeige CBX4 Antikörper) may serve as a tumor suppressor in colorectal carcinoma by recruiting HDAC3 to the Runx2 (zeige RUNX2 Antikörper) promoter to impede Runx2 (zeige RUNX2 Antikörper) expression
HDAC3 deletion displayed decreased pancreatic insulin content, disrupted glucose-stimulated insulin secretion, with intermittent spontaneous diabetes and dramatically enhanced susceptibility to STZ-induced diabetes.
Mice lacking HDAC3 in intestinal epithelial cells were more susceptible to Citrobacter rodentium. HDAC3 mediates communication between intestinal epithelial cells and resident lymphocytes.
Hepcidin (zeige HAMP Antikörper) expression involves epigenetic regulation by histone deacetylase 3.
HDAC3 interacts with PROX1 (zeige C16orf35 Antikörper).HDAC3 controls expression of genes regulating lipid homeostasis.
Studied effect of Coptis Chinensis on glioma cells; results showed Coptis Chinensis induced cell cycle arrest and apoptosis in glioma cells, down-regulated the signal transducer and activator oftranscription 3 (STAT3 (zeige STAT3 Antikörper)) phosphorylation levels, and reduced the expression of histone deacetylase 3 (HDAC3). (HDAC3) and caspase 3 (zeige CASP3 Antikörper).
The authors observed that the mouse cytomegalovirus encoded protein m18 is necessary and sufficient to drive expression of the RAE-1 (zeige RAE1 Antikörper) family of NKG2D (zeige KLRK1 Antikörper) ligands. RAE-1 (zeige RAE1 Antikörper) is transcriptionally repressed by histone deacetylase (zeige HDAC1 Antikörper) inhibitor 3 (zeige PPP1R11 Antikörper) (HDAC3) in healthy cells, and m18 relieves this repression by directly interacting with Casein Kinase II (zeige CSNK2A1 Antikörper) and preventing it from activating HDAC3.
Emerin (zeige EMD Antikörper)-null progenitors were delayed in their cell cycle exit, had decreased myosin heavy chain (MyHC (zeige MYH13 Antikörper)) expression and formed fewer myotubes. Emerin (zeige EMD Antikörper) binds to and activates histone deacetylase 3 (HDAC3).
Hdac3 is a key epigenetic modifier that maintains blood-lymph separation and integrates both extrinsic forces and intrinsic cues to regulate lymphatic valve development.
HDAC3 controls the temporal and spatial expression of tissue-remodeling genes and inflammatory responses in chondrocytes to ensure proper endochondral ossification during development.
HDAC3, through deacetylating tubulin (zeige TUBB Antikörper), promotes microtubule stability and the establishment of kinetochore-microtubule interaction, consequently ensuring proper spindle morphology, accurate chromosome movement and orderly meiotic progression during oocyte maturation
HDAC3 plays a crucial role in regulating posterior lateral line (PLL) formation and provide evidence for epigenetic regulation in auditory organ development.
These results revealed a novel and specific role of hdac3 in liver development and the distinct functions between hdac1 (zeige HDAC1 Antikörper) and hdac3 in zebrafish embryonic development.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
, histone Deacetylase-3
, histone deacetylase 3
, HDAC3 splicing HDAC3alpha
, HDAC3 splicing HDAC3beta
, HDAC3 splicing HDAC3delta
, HDAC3 splicing HDAC3gamma
, histone deacetylase-3