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Human HDAC1 Protein expressed in Wheat germ - ABIN1306440
Esposito, Pierantoni, Battista, Melillo, Scala, Chieffi, Fedele, Fusco: Interaction between HMGA1 and retinoblastoma protein is required for adipocyte differentiation. in The Journal of biological chemistry 2009
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reduced HDAC1 levels at promotors of distinct plasticity-associated genes predispose animals exposed to early life stress to enhanced expression of these genes upon cognitive challenge
HDAC1 SUMOylation functions as an endogenous defense mechanism protecting against Abeta (zeige APP Proteine)-toxicity. Stimuli such as BDNF (zeige BDNF Proteine), IGF-1 (zeige IGF1 Proteine) and CRF (zeige CRH Proteine) that increase the level of HDAC1 SUMOylation without altering the HDAC1 expression level
Mechanical stimulation orchestrates the osteogenic differentiation of human bone marrow stromal cells by regulating HDAC1.
Co-regulation of H3K9ac by HDAC1 and HDAC3 (zeige HDAC3 Proteine) is important to both embryonic brain development and neuro-differentiation.
Treatment of the haplotype Npr1 (zeige NPR1 Proteine)(+/-) mice with histone deacetylase inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1/2, NF-kappaB (zeige NFKB1 Proteine) (p65 (zeige NFkBP65 Proteine)), and STAT1 (zeige STAT1 Proteine).
Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 (zeige CREBBP Proteine) and HDAC1-HDAC2 has been described.
Here, we use transgenic lines to define the in vivo relevance of HDAC1 and identify calcineurin-dependent serine dephosphorylation as the signal modulating the neurotoxic role of HDAC1 in response to neurotoxic stimuli.
In line with the acetyltransferase activity of p300 (zeige NOTCH1 Proteine), H3K27 acetylation was reduced after HDACi and resulted in the formation of heterochromatin in the PTGES1 gene. In conclusion, HDAC (zeige HDAC3 Proteine) activity maintains PTGES1 expression by recruiting p300 (zeige NOTCH1 Proteine) to its gene
provide new insight into the upstream regulation of Sap90/Psd95 (zeige DLG4 Proteine)-associated protein 3 (zeige HSPB3 Proteine) and establish the essential role of striatal Hdac1, Hdac2 (zeige HDAC2 Proteine) and MeCP2 for suppression of repetitive behaviors
Taken together, Fam60a is an essential core subunit of a variant Sin3a (zeige SIN3A Proteine)-Hdac (zeige HDAC3 Proteine) complex in embryonic stem cells that is required to promote rapid proliferation and prevent unscheduled differentiation.
These results reveal the presence of an MSI1 (zeige MSI1 Proteine)-HDA19 complex that fine-tunes abscissic acid signaling in Arabidopsis.
HDC1 is a ubiquitously expressed nuclear protein that interacts with at least two deacetylases (HDA6 (zeige HDAC6 Proteine) and HDA19), promotes histone deacetylation, and attenuates derepression of genes under water stress.
HDA19 and HSL1 may act together to repress seed maturation gene expression during germination. HDA19 and HSL1 may play a vital role during embryogenesis.
findings show that AP2 represses its target genes by physically recruiting the co-repressor TOPLESS and the histone deacetylase HDA19
HDA6 (zeige HDAC6 Proteine) and HDA19 may play a redundant role in modulating seed germination and salt stress response, as well as ABA- and salt stress-induced gene expression in Arabidopsis.[HDA19]
Data suggest that AtHD1 is a nuclear protein and possesses histone deacetylase activities responsible for global transcriptional regulation important to plant growth and development.
These results suggest that acetylation of specific histone Lys (zeige LYZ Proteine) residues, regulated by GCN5, TAF1, and HD1, is required for light-regulated gene expression.
These results suggest that during germination in Arabidopsis, HDA6 (zeige HDAC6 Proteine) and HDA19 redundantly regulate the repression of embryonic properties directly or indirectly via repression of embryo-specific gene function.
aken together, these results reveal that inactivation of Rpd3 independently regulates JNK (zeige MAPK8 Proteine) and Yki (zeige YAP1 Proteine) activities and that both Hippo and JNK (zeige MAPK8 Proteine) signaling pathways contribute to Rpd3 RNAi-induced apoptosis.
Rpd3 accumulates in the nucleolus in the early stage of starvation, upregulates rRNA synthesis, maintains the polysome amount for translation, and finally increases stress tolerance proteins, such as autophagy-related proteins, to acquire starvation stress resistance.
Hdac1/Rpd3 functions together with self-renewal transcriptional repressors to maintain the erm (zeige MSN Proteine) immature intermediate neural progenitors enhancer in an inactive but poised state in neuroblasts.
This study tested the longevity effects of RPD3 on multiple nutrient levels.
Rpd3 deacetylase in the heart plays a significant role in cardiac function and longevity to systemically modulate the fly's response to the environment
the Atro-Rpd3 complex plays a conserved role to function as a Ci(R) corepressor.
Study shows that Fru forms a complex with the transcriptional cofactor Bonus (Bon), which, in turn, recruits either of two chromatin regulators, Histone deacetylase 1 (HDAC1), which masculinizes individual sexually dimorphic neurons, or Heterochromatin protein 1a (HP1a (zeige CBX5 Proteine)), which demasculinizes them.
The dose of Rpd3 is critical for normal long-term memory.
Work suggests that Drosophila telomere structure is epigenetically regulated by the histone deacetylase Rpd3.
Our study suggests a specific function for the general chromatin remodeling factor (zeige ASH1L Proteine) Rpd3 in regulating dendrite targeting in neurons, largely through the postmitotic action of the Pros transcription factor.
Results show that histone deacetylase 1 (HDAC1) expression was positively correlated with YY1 transcription factor (YY1 (zeige YY1 Proteine)) in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) cell lines and primary tumor tissues.
the combination of p63 (zeige RPE65 Proteine)-positive and HDAC1-negative expressions can be a potential new way for distinguishing epidermal stem cells.
Furthermore, the results also demonstrate that the stability of GCPII (zeige FOLH1 Proteine) protein is regulated by HDAC1 through acetylation at the lysine 479 residue.
Nuclear HDAC2 (zeige HDAC2 Proteine) immunopositivity was significantly higher in actinic cheilitis (AC) when compared with lip squamous cell carcinoma (LSCC). HDAC1 and HAT1 (zeige HAT1 Proteine) nuclear immunostaining were higher in AC, with no statistical significance. When comparing data with our previous study, we found a positive correlation between HDAC1 X DNMT1 (zeige DNMT1 Proteine)/DNMT3b (zeige DNMT3B Proteine), HDAC2 (zeige HDAC2 Proteine) X DNMT3b (zeige DNMT3B Proteine), and HAT1 (zeige HAT1 Proteine) X DNMT1 (zeige DNMT1 Proteine)/DNMT3b (zeige DNMT3B Proteine) for certain studied groups.
data reveal the mechanism by which chromatin remodeling and target gene expression are regulated by Ikaros (zeige IKZF1 Proteine) alone and in complex with HDAC1 in B-ALL
Histone deacetylases 1 and 2 cooperate in regulating BRCA1, CHK1 (zeige CHEK1 Proteine), and RAD51 (zeige RAD51 Proteine) expression in acute myeloid leukemia (zeige BCL11A Proteine) cells.
our findings identify a key role for c-Myc (zeige MYC Proteine) in TRAIL deregulation and as a biomarker of the anticancer action of HDACi in acute myeloid leukemia (zeige BCL11A Proteine) .
The authors found that 2-aminoacetophenone regulates histone deacetylase 1 expression and activity, resulting in hypo-acetylation of lysine 18 of histone H3 (zeige HIST3H3 Proteine) at pro-inflammatory cytokine loci. Specifically, 2-aminoacetophenone induced reprogramming of immune cells occurs via alterations in histone acetylation of immune cytokines in vivo and in vitro.
Results suggest that RBM45 (zeige RBM45 Proteine) serves as a negative regulator to prevent FUS (zeige FUS Proteine)-mediated excessive recruitment of HDAC1 to the sites of DNA damage.
Histone deacetylases (HDACs) inhibitor MGCD0103 (MGCD) induces apoptosis by up-regulating p53 (zeige TP53 Proteine) in CNE2 nasopharyngeal carcinoma (NPC (zeige NPC1 Proteine)) cells.
The effect of p53 (zeige TP53 Proteine) expression on the development of cloned embryos, and its interaction with HDAC1 and DNMT3A (zeige DNMT3A Proteine) are reported.
The results suggest that HDAC1 knock-down in oocytes did not influence the rates of maturation or cleavage of parthenogenetic embryos.
results indicate that HDAC1 plays an important role in otic vesicle formation.
HDAC (zeige HDAC3 Proteine) activity is necessary for control of cell proliferation and migration of posterior lateral line primordium and hair cell differentiation during early stages of its development in zebrafish.
This study reveals distinct functional and temporal requirements for zebrafish hdac1 during neural crest-derived craniofacial and peripheral neuron development.
Hdac1 is required for expression of erm (zeige ETV5 Proteine) and fgf20a in rhombomeres; Hdac1-dependent expression of these two genes is attenuated in rhombomere boundary regions by Notch (zeige NOTCH1 Proteine) signalling activity
HDAC1 is required for pancreatic epithelial proliferation in development and cancer.
Data indicate a novel role for Hdac1 as a positive regulator of gene transcription during development of the vertebrate CNS.
Findings suggest that Mta3 (zeige MTA1 Proteine)-NuRD complex, inclding component HDAC1, is essential for the initiation of primitive hematopoiesis.
hdac1 is an essential component of the transcriptional silencing machinery that supports the formation and subsequent differentiation of neuronal precursors.
hdac1 is required for the normal formation of craniofacial cartilage and pectoral fins.
in vivo role of HDAC1 in regulating cell cycle progression is region-specific, as HDAC1 promotes cell cycle exit in the retina
Data show that proto-oncogene transcription factor Ets1 regulates neural crest development through histone deacetylase 1 HDAC1) to down-regulate bone morphogenetic protein (BMP) signaling output and reduce id3 protein expression.
Specific knockdown of HDAC1 by a morpholino (HDAC1-MO) decreased the number of BrdU- and BLBP-labeled cells and increased the acetylation level of histone H4 at lysine 12.
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
reduced potassium dependency, yeast homolog-like 1
, Rpd3 histone deacetylase
, histone Deacetylase-1
, histone deacetylase
, histone deacetylase 1
, histone deacetylase 1 (HDAC1)
, reduced potassium dependency 3
, suppressor of variegation 326
, histone deacetylase 1 b
, histone deacetylase 1-B
, histone deacetylase 1 a
, maternally-expressed histone deacetylase
, probable histone deacetylase 1-A
, yeast RPD3 homologue