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Human HDAC1 Protein expressed in Wheat germ - ABIN1306440
Esposito, Pierantoni, Battista, Melillo, Scala, Chieffi, Fedele, Fusco: Interaction between HMGA1 and retinoblastoma protein is required for adipocyte differentiation. in The Journal of biological chemistry 2009
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Data show there is allosteric communication between the inositol-binding site and the active sites in histone deacetylases HDAC1 and HDAC3 (zeige HDAC3 Proteine).
High HDAC1 expression is associated with gastrointestinal malignancy.
Results show that proteasomal degradation of HDAC1 and HDAC3 (zeige HDAC3 Proteine) by Vpr counteracts HIV-1 latency to reactivate the viral promoter.
concomitant LSD1 (zeige KDM1A Proteine) and HDAC (zeige HDAC3 Proteine) inhibition synergistically induces cell death in rhabdomyosarcoma cells by shifting the ratio of pro- and antiapoptotic BCL-2 (zeige BCL2 Proteine) proteins in favor of apoptosis, thereby engaging the intrinsic apoptotic pathway
HDAC1 depletion activates cardiac mesenchymal stromal cells proangiogenic paracrine signaling in a basic fibroblast growth factor (zeige FGF2 Proteine)-dependent manner.
Hdac1 levels are increased in blood samples from patients with schizophrenia who had encountered early life stress (ELS), compared with patients without ELS exp (zeige HELLS Proteine)erience.
HDAC1 and HDAC2 suppress the expression of PPP2R3A/PR130, a regulatory subunit of the trimeric serine/threonine phosphatase 2 (PP2A).
HDAC1 may therefore be considered an unfavorable progression indicator for glioma patients, and may also serve as a potential therapeutic target.
new basis of DDX23-Linc00630-HDAC1 signal axis for understanding its pathogenicity, which could be further developed as a valuable therapeutic strategy
Results show that histone deacetylase 1 (HDAC1) expression was positively correlated with YY1 transcription factor (YY1 (zeige YY1 Proteine)) in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) cell lines and primary tumor tissues.
aken together, these results reveal that inactivation of Rpd3 independently regulates JNK (zeige MAPK8 Proteine) and Yki (zeige YAP1 Proteine) activities and that both Hippo and JNK (zeige MAPK8 Proteine) signaling pathways contribute to Rpd3 RNAi-induced apoptosis.
Rpd3 accumulates in the nucleolus in the early stage of starvation, upregulates rRNA synthesis, maintains the polysome amount for translation, and finally increases stress tolerance proteins, such as autophagy-related proteins, to acquire starvation stress resistance.
Hdac1/Rpd3 functions together with self-renewal transcriptional repressors to maintain the erm (zeige MSN Proteine) immature intermediate neural progenitors enhancer in an inactive but poised state in neuroblasts.
This study tested the longevity effects of RPD3 on multiple nutrient levels.
Rpd3 deacetylase in the heart plays a significant role in cardiac function and longevity to systemically modulate the fly's response to the environment
the Atro-Rpd3 complex plays a conserved role to function as a Ci(R) corepressor.
Study shows that Fru forms a complex with the transcriptional cofactor Bonus (Bon), which, in turn, recruits either of two chromatin regulators, Histone deacetylase 1 (HDAC1), which masculinizes individual sexually dimorphic neurons, or Heterochromatin protein 1a (HP1a (zeige CBX5 Proteine)), which demasculinizes them.
The dose of Rpd3 is critical for normal long-term memory.
Work suggests that Drosophila telomere structure is epigenetically regulated by the histone deacetylase Rpd3.
Our study suggests a specific function for the general chromatin remodeling factor (zeige ASH1L Proteine) Rpd3 in regulating dendrite targeting in neurons, largely through the postmitotic action of the Pros transcription factor.
Data show that proto-oncogene transcription factor Ets1 regulates neural crest development through histone deacetylase 1 HDAC1) to down-regulate bone morphogenetic protein (BMP) signaling output and reduce id3 protein expression.
Specific knockdown of HDAC1 by a morpholino (HDAC1-MO) decreased the number of BrdU- and BLBP-labeled cells and increased the acetylation level of histone H4 at lysine 12.
data represent a step towards the comprehension of HDAC1 regulation by its PTM code, with important implications in unravelling its roles both in physiology and pathology
results indicate that HDAC1 plays an important role in otic vesicle formation.
HDAC (zeige HDAC3 Proteine) activity is necessary for control of cell proliferation and migration of posterior lateral line primordium and hair cell differentiation during early stages of its development in zebrafish.
This study reveals distinct functional and temporal requirements for zebrafish hdac1 during neural crest-derived craniofacial and peripheral neuron development.
Hdac1 is required for expression of erm (zeige ETV5 Proteine) and fgf20a in rhombomeres; Hdac1-dependent expression of these two genes is attenuated in rhombomere boundary regions by Notch (zeige NOTCH1 Proteine) signalling activity
HDAC1 is required for pancreatic epithelial proliferation in development and cancer.
Data indicate a novel role for Hdac1 as a positive regulator of gene transcription during development of the vertebrate CNS.
Findings suggest that Mta3 (zeige MTA1 Proteine)-NuRD complex, inclding component HDAC1, is essential for the initiation of primitive hematopoiesis.
hdac1 is an essential component of the transcriptional silencing machinery that supports the formation and subsequent differentiation of neuronal precursors.
hdac1 is required for the normal formation of craniofacial cartilage and pectoral fins.
The effect of p53 (zeige TP53 Proteine) expression on the development of cloned embryos, and its interaction with HDAC1 and DNMT3A (zeige DNMT3A Proteine) are reported.
The results suggest that HDAC1 knock-down in oocytes did not influence the rates of maturation or cleavage of parthenogenetic embryos.
the epigenetic regulators HDAC1 and HDAC2 (zeige HDAC2 Proteine) control nephrogenesis via interactions with the transcriptional programs of nephron progenitors and renal vesicles.
These data suggest that HDAC1-related H3K9ac plays a key role in Hcy-mediated lipid metabolism disorders, and that miR (zeige MLXIP Proteine)-34a may be a novel therapeutic target in Hcy-related atherosclerosis.
Early life stress (ELS)-induced schizophrenia-like phenotypes correlate with a widespread increase of Hdac1 expression that is linked to altered DNA methylation (zeige HELLS Proteine). Hdac1 overexpression in neurons of the medial prefrontal cortex, but not in the dorsal or ventral hippocampus, mimics schizophrenia-like phenotypes induced by ELS.
e results showed mTet1 modified mGSCs had better self-renewal and proliferation ability than wild-type mGSCs, mTet1 could also up-regulate JMJD3 to decrease H3K27me3, which also showed to suppress the MEK (zeige MDK Proteine)-ERK (zeige EPHB2 Proteine) pathway. Furthermore, Co-IP analysis demonstrated that TET1 (zeige TET1 Proteine) interact with PCNA (zeige PCNA Proteine) and HDAC1 by forming protein complexes to comprehensively regulate dairy goat mGSCs and spermatogenesis.
reduced HDAC1 levels at promotors of distinct plasticity-associated genes predispose animals exposed to early life stress to enhanced expression of these genes upon cognitive challenge
HDAC1 SUMOylation functions as an endogenous defense mechanism protecting against Abeta (zeige APP Proteine)-toxicity. Stimuli such as BDNF (zeige BDNF Proteine), IGF-1 (zeige IGF1 Proteine) and CRF (zeige CRH Proteine) that increase the level of HDAC1 SUMOylation without altering the HDAC1 expression level
Mechanical stimulation orchestrates the osteogenic differentiation of human bone marrow stromal cells by regulating HDAC1.
Co-regulation of H3K9ac by HDAC1 and HDAC3 (zeige HDAC3 Proteine) is important to both embryonic brain development and neuro-differentiation.
Treatment of the haplotype Npr1 (zeige NPR1 Proteine)(+/-) mice with histone deacetylase inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1/2, NF-kappaB (zeige NFKB1 Proteine) (p65 (zeige NFkBP65 Proteine)), and STAT1 (zeige STAT1 Proteine).
Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 (zeige CREBBP Proteine) and HDAC1-HDAC2 has been described.
These results reveal the presence of an MSI1 (zeige MSI1 Proteine)-HDA19 complex that fine-tunes abscissic acid signaling in Arabidopsis.
HDC1 is a ubiquitously expressed nuclear protein that interacts with at least two deacetylases (HDA6 (zeige HDAC6 Proteine) and HDA19), promotes histone deacetylation, and attenuates derepression of genes under water stress.
HDA19 and HSL1 may act together to repress seed maturation gene expression during germination. HDA19 and HSL1 may play a vital role during embryogenesis.
findings show that AP2 represses its target genes by physically recruiting the co-repressor TOPLESS and the histone deacetylase HDA19
HDA6 (zeige HDAC6 Proteine) and HDA19 may play a redundant role in modulating seed germination and salt stress response, as well as ABA- and salt stress-induced gene expression in Arabidopsis.[HDA19]
Data suggest that AtHD1 is a nuclear protein and possesses histone deacetylase activities responsible for global transcriptional regulation important to plant growth and development.
These results suggest that acetylation of specific histone Lys (zeige LYZ Proteine) residues, regulated by GCN5, TAF1, and HD1, is required for light-regulated gene expression.
These results suggest that during germination in Arabidopsis, HDA6 (zeige HDAC6 Proteine) and HDA19 redundantly regulate the repression of embryonic properties directly or indirectly via repression of embryo-specific gene function.
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (zeige DNMT1 Proteine), Dnmt3a (zeige DNMT3A Proteine), Hdac1, Kdm3a (zeige KDM3A Proteine) and Uhrf1 (zeige UHRF1 Proteine) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
reduced potassium dependency, yeast homolog-like 1
, Rpd3 histone deacetylase
, histone Deacetylase-1
, histone deacetylase
, histone deacetylase 1
, histone deacetylase 1 (HDAC1)
, reduced potassium dependency 3
, suppressor of variegation 326
, histone deacetylase 1 b
, histone deacetylase 1-B
, histone deacetylase 1 a
, maternally-expressed histone deacetylase
, probable histone deacetylase 1-A
, yeast RPD3 homologue