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Human Polyclonal HDAC1 Primary Antibody für ChIP, ICC - ABIN4316728
Fischle, Emiliani, Hendzel, Nagase, Nomura, Voelter, Verdin: A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p. in The Journal of biological chemistry 1999
Show all 12 Pubmed References
Human Polyclonal HDAC1 Primary Antibody für IHC, IHC (fro) - ABIN4316727
Wilting, Yanover, Heideman, Jacobs, Horner, van der Torre, DePinho, Dannenberg: Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis. in The EMBO journal 2010
Show all 9 Pubmed References
Human Polyclonal HDAC1 Primary Antibody für WB - ABIN1881405
Yang, Zhou, Wu, Xie, Zhang, Zheng: Combination of polymorphisms within the HDAC1 and HDAC3 gene predict tumor recurrence in hepatocellular carcinoma patients that have undergone transplant therapy. in Clinical chemistry and laboratory medicine : CCLM / FESCC 2010
Show all 5 Pubmed References
Human Monoclonal HDAC1 Primary Antibody für ChIP, ICC - ABIN2668767
Lagger, OCarroll, Rembold, Khier, Tischler, Weitzer, Schuettengruber, Hauser, Brunmeir, Jenuwein, Seiser: Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. in The EMBO journal 2002
Show all 4 Pubmed References
Human Monoclonal HDAC1 Primary Antibody für WB - ABIN1882195
Furukawa, Kawakami, Sudo, Inazawa, Matsumine, Akiyama, Nakamura: Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae. in Cytogenetics and cell genetics 1996
Show all 5 Pubmed References
Human Polyclonal HDAC1 Primary Antibody für IP, IHC - ABIN223295
Cao, Li, Zhu, Shen, Han, Zhang, Yu, Wang, Wu, Chen, Sun, Tang, Zhao, Qiao, Hou, Mao: The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity. in The Journal of biological chemistry 2013
Show all 2 Pubmed References
Rat (Rattus) Polyclonal HDAC1 Primary Antibody für ELISA, WB - ABIN1574070
Biggar, Storey: Global DNA modifications suppress transcription in brown adipose tissue during hibernation. in Cryobiology 2014
Human Polyclonal HDAC1 Primary Antibody für IHC, ELISA - ABIN1043884
Unoki, Nishidate, Nakamura: ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. in Oncogene 2004
Human Monoclonal HDAC1 Primary Antibody für IF, IHC (p) - ABIN516392
Nakayama, Mikoshiba, Akagawa: The cell- and tissue-specific transcription mechanism of the TATA-less syntaxin 1A gene. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016
reduced HDAC1 levels at promotors of distinct plasticity-associated genes predispose animals exposed to early life stress to enhanced expression of these genes upon cognitive challenge
HDAC1 SUMOylation functions as an endogenous defense mechanism protecting against Abeta (zeige APP Antikörper)-toxicity. Stimuli such as BDNF (zeige BDNF Antikörper), IGF-1 (zeige IGF1 Antikörper) and CRF (zeige CRH Antikörper) that increase the level of HDAC1 SUMOylation without altering the HDAC1 expression level
Mechanical stimulation orchestrates the osteogenic differentiation of human bone marrow stromal cells by regulating HDAC1.
Co-regulation of H3K9ac by HDAC1 and HDAC3 (zeige HDAC3 Antikörper) is important to both embryonic brain development and neuro-differentiation.
Treatment of the haplotype Npr1 (zeige NPR1 Antikörper)(+/-) mice with histone deacetylase inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1/2, NF-kappaB (zeige NFKB1 Antikörper) (p65 (zeige NFkBP65 Antikörper)), and STAT1 (zeige STAT1 Antikörper).
Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 (zeige CREBBP Antikörper) and HDAC1-HDAC2 has been described.
Here, we use transgenic lines to define the in vivo relevance of HDAC1 and identify calcineurin-dependent serine dephosphorylation as the signal modulating the neurotoxic role of HDAC1 in response to neurotoxic stimuli.
In line with the acetyltransferase activity of p300 (zeige NOTCH1 Antikörper), H3K27 acetylation was reduced after HDACi and resulted in the formation of heterochromatin in the PTGES1 gene. In conclusion, HDAC (zeige HDAC3 Antikörper) activity maintains PTGES1 expression by recruiting p300 (zeige NOTCH1 Antikörper) to its gene
provide new insight into the upstream regulation of Sap90/Psd95 (zeige DLG4 Antikörper)-associated protein 3 (zeige HSPB3 Antikörper) and establish the essential role of striatal Hdac1, Hdac2 (zeige HDAC2 Antikörper) and MeCP2 for suppression of repetitive behaviors
Taken together, Fam60a is an essential core subunit of a variant Sin3a (zeige SIN3A Antikörper)-Hdac (zeige HDAC3 Antikörper) complex in embryonic stem cells that is required to promote rapid proliferation and prevent unscheduled differentiation.
These results reveal the presence of an MSI1 (zeige MSI1 Antikörper)-HDA19 complex that fine-tunes abscissic acid signaling in Arabidopsis.
HDC1 is a ubiquitously expressed nuclear protein (zeige UBN1 Antikörper) that interacts with at least two deacetylases (HDA6 (zeige HDAC6 Antikörper) and HDA19), promotes histone deacetylation, and attenuates derepression of genes under water stress.
HDA19 and HSL1 may act together to repress seed maturation gene expression during germination. HDA19 and HSL1 may play a vital role during embryogenesis.
findings show that AP2 represses its target genes by physically recruiting the co-repressor TOPLESS and the histone deacetylase HDA19
HDA6 (zeige HDAC6 Antikörper) and HDA19 may play a redundant role in modulating seed germination and salt stress response, as well as ABA- and salt stress-induced gene expression in Arabidopsis.[HDA19]
Data suggest that AtHD1 is a nuclear protein (zeige HEMGN Antikörper) and possesses histone deacetylase activities responsible for global transcriptional regulation important to plant growth and development.
These results suggest that acetylation of specific histone Lys (zeige LYZ Antikörper) residues, regulated by GCN5, TAF1, and HD1, is required for light-regulated gene expression.
These results suggest that during germination in Arabidopsis, HDA6 (zeige HDAC6 Antikörper) and HDA19 redundantly regulate the repression of embryonic properties directly or indirectly via repression of embryo-specific gene function.
aken together, these results reveal that inactivation of Rpd3 independently regulates JNK (zeige MAPK8 Antikörper) and Yki (zeige YAP1 Antikörper) activities and that both Hippo and JNK (zeige MAPK8 Antikörper) signaling pathways contribute to Rpd3 RNAi-induced apoptosis.
Rpd3 accumulates in the nucleolus in the early stage of starvation, upregulates rRNA synthesis, maintains the polysome amount for translation, and finally increases stress tolerance proteins, such as autophagy-related proteins, to acquire starvation stress resistance.
Hdac1/Rpd3 functions together with self-renewal transcriptional repressors to maintain the erm (zeige MSN Antikörper) immature intermediate neural progenitors enhancer in an inactive but poised state in neuroblasts.
This study tested the longevity effects of RPD3 on multiple nutrient levels.
Rpd3 deacetylase in the heart plays a significant role in cardiac function and longevity to systemically modulate the fly's response to the environment
the Atro-Rpd3 complex plays a conserved role to function as a Ci(R) corepressor.
Study shows that Fru (zeige ZBTB22 Antikörper) forms a complex with the transcriptional cofactor Bonus (Bon), which, in turn, recruits either of two chromatin regulators, Histone deacetylase 1 (HDAC1), which masculinizes individual sexually dimorphic neurons, or Heterochromatin protein 1a (HP1a (zeige CBX5 Antikörper)), which demasculinizes them.
The dose of Rpd3 is critical for normal long-term memory.
Work suggests that Drosophila telomere structure is epigenetically regulated by the histone deacetylase Rpd3.
Our study suggests a specific function for the general chromatin remodeling factor (zeige ASH1L Antikörper) Rpd3 in regulating dendrite targeting in neurons, largely through the postmitotic action of the Pros transcription factor.
data reveal the mechanism by which chromatin remodeling and target gene expression are regulated by Ikaros (zeige IKZF1 Antikörper) alone and in complex with HDAC1 in B-ALL
Histone deacetylases 1 and 2 cooperate in regulating BRCA1, CHK1 (zeige CHEK1 Antikörper), and RAD51 (zeige RAD51 Antikörper) expression in acute myeloid leukemia (zeige BCL11A Antikörper) cells.
our findings identify a key role for c-Myc (zeige MYC Antikörper) in TRAIL deregulation and as a biomarker of the anticancer action of HDACi in acute myeloid leukemia (zeige BCL11A Antikörper) .
The authors found that 2-aminoacetophenone regulates histone deacetylase 1 expression and activity, resulting in hypo-acetylation of lysine 18 of histone H3 (zeige HIST3H3 Antikörper) at pro-inflammatory cytokine loci. Specifically, 2-aminoacetophenone induced reprogramming of immune cells occurs via alterations in histone acetylation of immune cytokines in vivo and in vitro.
Results suggest that RBM45 (zeige RBM45 Antikörper) serves as a negative regulator to prevent FUS (zeige FUS Antikörper)-mediated excessive recruitment of HDAC1 to the sites of DNA damage.
Histone deacetylases (HDACs) inhibitor MGCD0103 (MGCD) induces apoptosis by up-regulating p53 (zeige TP53 Antikörper) in CNE2 nasopharyngeal carcinoma (NPC (zeige NPC1 Antikörper)) cells.
Our findings suggest that up-regulation of UVRAG (zeige UVRAG Antikörper) by HDAC1 inhibition potentiates DNA-damage-mediated cell death in colorectal cancer cells
The findings suggest that OGT (zeige OGT Antikörper) promotes the O-GlcNAc (zeige OGT Antikörper) modification of HDAC1 in the development of progression hepatocellular carcinoma.
HDAC1 promoted migration and invasion of gallbladder tumor cells by binding with TCF12 (zeige TCF12 Antikörper) to promote epithelial mesenchymal transformation.
HDAC1 depletion-induced p53 (zeige TP53 Antikörper) expression alters cardiac-derived mesenchymal stromal cell fate decisions.
The effect of p53 (zeige TP53 Antikörper) expression on the development of cloned embryos, and its interaction with HDAC1 and DNMT3A (zeige DNMT3A Antikörper) are reported.
The results suggest that HDAC1 knock-down in oocytes did not influence the rates of maturation or cleavage of parthenogenetic embryos.
results indicate that HDAC1 plays an important role in otic vesicle formation.
HDAC (zeige HDAC3 Antikörper) activity is necessary for control of cell proliferation and migration of posterior lateral line primordium and hair cell differentiation during early stages of its development in zebrafish.
This study reveals distinct functional and temporal requirements for zebrafish hdac1 during neural crest-derived craniofacial and peripheral neuron development.
Hdac1 is required for expression of erm (zeige ETV5 Antikörper) and fgf20a in rhombomeres; Hdac1-dependent expression of these two genes is attenuated in rhombomere boundary regions by Notch (zeige NOTCH1 Antikörper) signalling activity
HDAC1 is required for pancreatic epithelial proliferation in development and cancer.
Data indicate a novel role for Hdac1 as a positive regulator of gene transcription during development of the vertebrate CNS.
Findings suggest that Mta3 (zeige MTA1 Antikörper)-NuRD complex, inclding component HDAC1, is essential for the initiation of primitive hematopoiesis.
hdac1 is an essential component of the transcriptional silencing machinery that supports the formation and subsequent differentiation of neuronal precursors.
hdac1 is required for the normal formation of craniofacial cartilage and pectoral fins.
in vivo role of HDAC1 in regulating cell cycle progression is region-specific, as HDAC1 promotes cell cycle exit in the retina
Data show that proto-oncogene transcription factor Ets1 regulates neural crest development through histone deacetylase 1 HDAC1) to down-regulate bone morphogenetic protein (BMP) signaling output and reduce id3 protein expression.
Specific knockdown of HDAC1 by a morpholino (HDAC1-MO) decreased the number of BrdU- and BLBP-labeled cells and increased the acetylation level of histone H4 at lysine 12.
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
, histone deacetylase 1
, histone deacetylase 1-B
, Rpd3 histone deacetylase
, histone Deacetylase-1
, histone deacetylase
, histone deacetylase 1 (HDAC1)
, reduced potassium dependency 3
, suppressor of variegation 326
, reduced potassium dependency, yeast homolog-like 1
, histone deacetylase 1 b