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anti-Human DUSP6 Antikörper:
anti-Mouse (Murine) DUSP6 Antikörper:
anti-Rat (Rattus) DUSP6 Antikörper:
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Human Monoclonal DUSP6 Primary Antibody für IF, IHC (p) - ABIN560670
Okudela, Yazawa, Woo, Sakaeda, Ishii, Mitsui, Shimoyamada, Sato, Tajiri, Ogawa, Masuda, Takahashi, Sugimura, Kitamura: Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis. in The American journal of pathology 2009
Show all 3 Pubmed References
Rat (Rattus) Polyclonal DUSP6 Primary Antibody für FACS, WB - ABIN1882185
Muda, Boschert, Dickinson, Martinou, Martinou, Camps, Schlegel, Arkinstall: MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. in The Journal of biological chemistry 1996
Show all 3 Pubmed References
Human Polyclonal DUSP6 Primary Antibody für IHC - ABIN966015
Groom, Sneddon, Alessi, Dowd, Keyse: Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. in The EMBO journal 1996
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Human Polyclonal DUSP6 Primary Antibody für ELISA, WB - ABIN4334835
Geetha, Mihaly, Stockenhuber, Blasi, Uhrin, Binder, Freissmuth, Breuss et al.: Signal integration and coincidence detection in the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) cascade: concomitant activation of receptor tyrosine kinases and of ... in The Journal of biological chemistry 2011
Lef1 (zeige LEF1 Antikörper) has a role in regulating Dusp6 in formation of the zebrafish posterior lateral line primordium
During fin development, dusp6, a known MAPK/ERK (zeige MAPK1 Antikörper) regulator, is induced in the mesoderm by FGF8 (zeige FGF8 Antikörper) signaling, through the PI3 (zeige PI3 Antikörper)/Akt (zeige AKT1 Antikörper) pathway.
Mkp3 encodes a feedback attenuator of the FGF pathway, the expression of which is initiated at an early stage so as to ensure correct FGF signaling levels at the time of axial patterning.
Retinoic acid-dependent control of MAP kinase phosphatase-3 is necessary for early kidney development.
Data show that oxidative stress and MAP kinase phosphatase 3 (MKP3) inhibition play a critical role in procyanidin B2 3,3''-di-O-gallate (B2G2)-induced cell death in prostate cancer (PCa (zeige FLVCR1 Antikörper)) cells through sustained activation of both ERK1/2 (zeige MAPK1/3 Antikörper) and AMPKalpha (zeige GRK4 Antikörper).
High DUSP6 expression is associated with Lung Squamous Cell Carcinoma.
Results show that DUSP5 (zeige DUSP5 Antikörper) and DUSP6 mRNA are overexpressed in human PTCs, especially in BRAFV600E mutated papillary thyroid carcinomas (PTCs), and positively control cell migration and invasion.
Authors demonstrate the broad applicability of this recombination-based method and they proved its potential to identify new drug targets via the identification of the tumor suppressor DUSP6 as potential synthetic lethal target in melanoma cell lines with BRAF (zeige BRAF Antikörper) V600E mutations and high DUSP6 expression.
PICSAR has a role in promoting cSCC (zeige CYP11A1 Antikörper) progression via activation of extracellular signal-regulated kinase 1/2 (zeige MAPK3 Antikörper) signaling pathway by downregulating DUSP6 expression
DUSP6 rs2279574 SNPs was not associated with chemoradiotherapy response, whereas tumor regression, weight loss, clinical stage, and cigarette smoking were independent prognostic predictors for these Chinese patients with non-small cell lung cancer.
DNA samples from each patient were genotyped for DUSP6 and TOP2A (zeige TOP2A Antikörper) SNPs
Suppression of the FOXA1 (zeige FOXA1 Antikörper)/DUSP6 signaling pathway may contribute to the development of Hirschsprung disease.
These observations led us to conclude that increased TSH signaling overcomes OIS and is essential for B-RafV600E-induced papillary thyroid carcinogenesis.
Dusp6 expression was higher in progestin-sensitive atypical endometrial hyperplasia groups compared with progestin-resistant groups. After treatment, Dusp6 expression was upregulated in progestin-sensitive groups, but not in progestin-resistant groups.
This study demonstrates that dusp6 deficiency is a strong genetic factor shaping gut (zeige GUSB Antikörper) microbiota, and that it confers obesity protection by ameliorating the gut (zeige GUSB Antikörper) microbiota response to diet-mediated stress.
DUSP6 deficiency has limited impact on the regulation of energy metabolism, but impairs systemic glucose tolerance.
this study shows that CCL2 (zeige CCL2 Antikörper) supports the classical activation of macrophages, with miR (zeige MLXIP Antikörper)-9 mediated down-regulation of Dusp6 and enhanced ERK (zeige EPHB2 Antikörper)-mediated signal transduction possibly mediating this enhanced pro-inflammatory gene expression
Mitogen-activated protein kinase phosphatase 3 upregulation requires the activation of the Erk1/2 (zeige MAPK1/3 Antikörper) pathway, which correlates with the shutdown of this pathway.
MKP3 could be an important factor in the regulation of brown adipocyte differentiation.
DUSP6 regulates CD4 (zeige CD4 Antikörper)+ T-cell activation and differentiation by inhibiting the TCR-dependent ERK1/2 (zeige MAPK1/3 Antikörper) activation and restraining spontaneous colitis in IL-10 (zeige IL10 Antikörper)-deficient mice.
exercised obese mice had a lower expression of MKP-3 and FoxO1 (zeige FOXO1 Antikörper)/MKP-3 association in the liver
c-Myb (zeige MYB Antikörper) plays an important role in H-Ras (zeige HRAS Antikörper)-induced MKP-3 transcription
Mice lacking MKP-3 protein develop an abnormal persistent state of mechanical allodynia following plantar incision, concurrent with long-lasting spinal phosphorylation of ERK-1 (zeige MAPK3 Antikörper)/2 and p38 (zeige CRK Antikörper).
Depletion of DUSP6 reduced the viability of cancer cell lines and increased the cytotoxicity of EGFR (zeige EGFR Antikörper) and other targeted inhibitors, and cytotoxic agents.
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.
MAP kinase phosphatase 3
, dual specificity protein phosphatase 6
, dual specificity protein phosphatase PYST1
, mitogen-activated protein kinase phosphatase 3
, serine/threonine specific protein phosphatase
, MAP kinase phosphatase X17C
, dual specificity phosphatase 6
, Dual specificity protein phosphatase 6
, dual specificity protein phosphatase 6-like