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The adaptor proteins Crk and Crk-like (Crkl (zeige CRKL Proteine)), with which Dock proteins are known to interact physically, are also required for myoblast fusion.
Crk-dependent increased phosphorylation of CD3zeta coincided with inhibition of TCR downmodulation, supporting a positive role for Crk adaptor proteins in TCR-mediated signal amplification.
This mini review will focus on the emerging roles of Crk adaptors during myocardial I/R injury.
TGF-beta (zeige TGFB1 Proteine) and Crk collaborate to form a positive feedback loop to facilitate epithelial-mesenchymal transition (EMT (zeige ITK Proteine)).
The results suggest the involvement of Crk adaptor proteins in the early stages of T cell activation in which Crk might help recruiting effector proteins to the vicinity of the phospho-CD3zeta (zeige CD247 Proteine) and contribute to the fine-tuning of the TCR/CD3 (zeige CD3 Proteine)-coupled signal transduction pathways.
Study investigated structures and thermodynamics of the interactions mediated by N-terminal Src homology 3 domain of CrkII and proline-rich motifs (PRMs) of cAbl kinase, highlight the role of interfacial water molecules and the conformational entropy in the SH3:PRM interactions
CrkII mediates IGF-1 (zeige IGF1 Proteine) signaling and further balances pancreatic ductal adenocarcinoma biological behaviors via Erk1/2 and Akt (zeige AKT1 Proteine) pathway
In individuals with class I 17p13.3 microduplications including CRK, we recommend biochemical evaluation of the growth hormone axis. Providers caring for these patients should be aware of their possible risk for the development of central precocious puberty.
Crk Tyr251 phosphorylation regulate invasive cell phenotypes in glioblastoma.
CsA (zeige ERCC8 Proteine) and FK506 might interfere with selected effector T cell functions via a CrkII-, but not CrkI-dependent mechanisms.
Studied the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC).
These results indicate that CCRK (zeige CDK20 Proteine) functions in eye development by both positively and negatively regulating the Hh pathway, and they reveal distinct requirements for Hh signaling in patterning and morphogenesis of the eyes.
the data suggest that CCRK (zeige CDK20 Proteine) positively regulates the kinetics by which ciliary proteins such as Smoothened and Gli2 are imported into the cilium, and that the efficiency of ciliary recruitment allows for potent responses to Hedgehog (zeige SHH Proteine) signaling over long time periods.
results suggest that Crk and CrkL (zeige CRKL Proteine) play essential overlapping roles in fibroblast growth.
both Crk and CrkL are required for the acquisition of cellular transformation by v-fos, whereas Crk plays a more prominent role than CrkL in v-ras-induced transformation.
results support a model in which Dok1 (zeige DOK1 Proteine) phosphorylation normally suppresses localized Ras pathway activity in Crk-transformed cells via recruitment and/or activation of RasGAP (zeige RASA1 Proteine)
Differential migration of CRK/CRKL (zeige CRKL Proteine)-deficient T cells resulted in efficient graft-versus-leukemia responses with minimal graft-versus-host disease in mice.
Crk1 (zeige MAPK14 Proteine)/2 and CrkL (zeige CRKL Proteine) are physically linked, functionally complement each other during podocyte foot process spreading, and together are required for developing typical foot process architecture.
Data suggest that interactions between Crk (proto-oncogene (zeige RAB1A Proteine) proteins c-crk) and Sos1 (Son of Sevenless homolog 1 (zeige SOS1 Proteine)) involve electrostatic interactions at binding sites.
Results suggest that Crk and CrkL (zeige CRKL Proteine) have critical roles in cell structure and motility by maintaining cytoskeletal integrity.
The v-Crk-myosin-1c interaction, which modulates membrane dynamics by regulating Rac1 activity, is crucial for cell adhesion and spreading.
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
, adapter molecule crk
, v-crk sarcoma virus CT10 oncogene homolog (avian)
, proto-oncogene c-Crk
, avian sarcoma virus CT10 (v-crk) oncogene homolog
, proto-oncogene C-crk
, v-crk sarcoma virus CT10 oncogene homolog
, SH2/SH3 adaptor Crk2
, SH2/SH3 adaptor crk
, CT-10 related kinase 3
, proto-oncogene c-crk
, v-crk sarcoma virus CT10 oncogene-like protein