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anti-Human Crk Antikörper:
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Chicken Monoclonal Crk Primary Antibody für BI, IP - ABIN967703
Cho, Klemke: Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold. in The Journal of cell biology 2002
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Chicken Monoclonal Crk Primary Antibody für BI, IP - ABIN967702
Fournier, Lamorte, Maroun, Lupher, Band, Langdon, Park: Cbl-transforming variants trigger a cascade of molecular alterations that lead to epithelial mesenchymal conversion. in Molecular biology of the cell 2000
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Human Monoclonal Crk Primary Antibody für ICC, FACS - ABIN969063
Watanabe, Tsuda, Tanaka, Ohba, Kawaguchi, Majima, Sawa, Minami: Adaptor protein Crk induces Src-dependent activation of p38 MAPK in regulation of synovial sarcoma cell proliferation. in Molecular cancer research : MCR 2009
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Human Monoclonal Crk Primary Antibody für ICC, FACS - ABIN969062
Tanaka: [Biological roles of signaling adaptor protein CRK]. in Seikagaku. The Journal of Japanese Biochemical Society 2009
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Human Polyclonal Crk Primary Antibody für PLA, WB - ABIN514601
Liu, Chen, Chau, Jan, Chen, Hsu, Lin, Juang, Lu, Cheng, Chen, Chang, Ting, Kao, Hsiao, Huang: Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma. in Molecular & cellular proteomics : MCP 2013
Human Polyclonal Crk Primary Antibody für ICC, IF - ABIN442021
Park, Choi, Choi, Kim, Kang, Jung, Lee, Kim, Freeman, Lee, Gho, Kim: Identification and characterization of proteins isolated from microvesicles derived from human lung cancer pleural effusions. in Proteomics 2013
The adaptor proteins Crk and Crk-like (Crkl (zeige CRKL Antikörper)), with which Dock proteins are known to interact physically, are also required for myoblast fusion.
Crk-dependent increased phosphorylation of CD3zeta coincided with inhibition of TCR downmodulation, supporting a positive role for Crk adaptor proteins in TCR-mediated signal amplification.
This mini review will focus on the emerging roles of Crk adaptors during myocardial I/R injury.
TGF-beta (zeige TGFB1 Antikörper) and Crk collaborate to form a positive feedback loop to facilitate epithelial-mesenchymal transition (EMT (zeige ITK Antikörper)).
The results suggest the involvement of Crk adaptor proteins in the early stages of T cell activation in which Crk might help recruiting effector proteins to the vicinity of the phospho-CD3zeta (zeige CD247 Antikörper) and contribute to the fine-tuning of the TCR/CD3 (zeige CD3 Antikörper)-coupled signal transduction pathways.
Study investigated structures and thermodynamics of the interactions mediated by N-terminal Src homology 3 domain of CrkII and proline-rich motifs (PRMs) of cAbl kinase, highlight the role of interfacial water molecules and the conformational entropy in the SH3:PRM interactions
CrkII mediates IGF-1 (zeige IGF1 Antikörper) signaling and further balances pancreatic ductal adenocarcinoma biological behaviors via Erk1/2 and Akt (zeige AKT1 Antikörper) pathway
In individuals with class I 17p13.3 microduplications including CRK, we recommend biochemical evaluation of the growth hormone axis. Providers caring for these patients should be aware of their possible risk for the development of central precocious puberty.
Crk Tyr251 phosphorylation regulate invasive cell phenotypes in glioblastoma.
CsA (zeige ERCC8 Antikörper) and FK506 might interfere with selected effector T cell functions via a CrkII-, but not CrkI-dependent mechanisms.
Studied the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC).
the data suggest that CCRK (zeige CDK20 Antikörper) positively regulates the kinetics by which ciliary proteins such as Smoothened and Gli2 (zeige GLI2 Antikörper) are imported into the cilium, and that the efficiency of ciliary recruitment allows for potent responses to Hedgehog (zeige SHH Antikörper) signaling over long time periods.
results suggest that Crk and CrkL (zeige CRKL Antikörper) play essential overlapping roles in fibroblast growth.
both Crk and CrkL are required for the acquisition of cellular transformation by v-fos, whereas Crk plays a more prominent role than CrkL in v-ras-induced transformation.
results support a model in which Dok1 (zeige DOK1 Antikörper) phosphorylation normally suppresses localized Ras pathway activity in Crk-transformed cells via recruitment and/or activation of RasGAP (zeige RASA1 Antikörper)
Differential migration of CRK/CRKL (zeige CRKL Antikörper)-deficient T cells resulted in efficient graft-versus-leukemia responses with minimal graft-versus-host disease in mice.
Crk1 (zeige MAPK14 Antikörper)/2 and CrkL (zeige CRKL Antikörper) are physically linked, functionally complement each other during podocyte foot process spreading, and together are required for developing typical foot process architecture.
Data suggest that interactions between Crk (proto-oncogene (zeige RAB1A Antikörper) proteins c-crk) and Sos1 (Son of Sevenless homolog 1 (zeige SOS1 Antikörper)) involve electrostatic interactions at binding sites.
Results suggest that Crk and CrkL (zeige CRKL Antikörper) have critical roles in cell structure and motility by maintaining cytoskeletal integrity.
The v-Crk-myosin-1c interaction, which modulates membrane dynamics by regulating Rac1 activity, is crucial for cell adhesion and spreading.
The authors cloned SH2 (zeige MYO15 Antikörper) domain-containing proteins they named GRBs (for growth factor receptor (zeige RYK Antikörper)-bound). They identified GRB-3 as having 77% identity at the protein level and 80% similarity at the DNA level to v-crk.
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
, adapter molecule crk
, v-crk sarcoma virus CT10 oncogene homolog (avian)
, proto-oncogene c-Crk
, avian sarcoma virus CT10 (v-crk) oncogene homolog
, proto-oncogene C-crk
, v-crk sarcoma virus CT10 oncogene homolog
, SH2/SH3 adaptor Crk2
, SH2/SH3 adaptor crk
, CT-10 related kinase 3
, proto-oncogene c-crk
, v-crk sarcoma virus CT10 oncogene-like protein