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We studied the function of LARG in murine and human megakaryocytes and platelets with Larg knockout (KO), shRNA-mediated knockdown and small molecule-mediated inhibition. We found that LARG is important for human, but not murine, megakaryocyte maturation.
that leukemia-associated Rho guanine-nucleotide exchange factor can be directly phosphorylated by cyclin-dependent kinase 1 (zeige CDK1 Proteine)
Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF (zeige ARHGEF11 Proteine) and leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical roles in signaling.
this study identified a novel association between IOP and ARHGEF12.
TGF-beta (zeige TGFB1 Proteine) regulates LARG and GEF-H1 (zeige ARHGEF2 Proteine) during epithelial-mesenchymal transition to affect stiffening response to force and cell invasion.
LARG is a novel and temporally distinct Rho Guanine Nucleotide Exchange Factor required for completion of abscission.
Data indicate that ICAM-1 (zeige ICAM1 Proteine) signaling activates leukemia-associated Rho guanine nucleotide exchange factor (LARG), also known as Rho GEF (zeige SLC2A4RG Proteine) 12 (ARHGEF12).
Agonist-induced Ca2 (zeige CA2 Proteine)+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
RhoGEF (zeige ARHGEF11 Proteine) activity of p210 BCR/ABL (zeige ABL1 Proteine) directly contributes to transforming activity, and may account for the difference in disease outcome associated with p190 (zeige CNTNAP1 Proteine) BCR/ABL (zeige ABL1 Proteine) and p210 BCR/ABL (zeige ABL1 Proteine).
NIS enhanced cell migration and invasion by binding to leukemia-associated RhoA (zeige RHOA Proteine) guanine exchange factor
Data found an inverse relationship between the expression of miR (zeige MLXIP Proteine)-660 and ARHGEF12 in both gain- and loss-of-function studies: overexpression of miR (zeige MLXIP Proteine)-660 declined the mRNA and protein expressions of ARHGEF12 in C2C12 cells differentiation; however, knockdown of miR (zeige MLXIP Proteine)-660 had completely opposite results.
This study demonstrated an almost 100-fold higher agonist sensitivity of the Galpha13 (zeige GNA13 Proteine) LARG interaction compared to the Galpha13 (zeige GNA13 Proteine) activation in the absence of LARG.
LARG may play a housekeeper role in regulating constitutive RhoA (zeige RHOA Proteine) activity. Its role in regulating platelet function may principally be through RhoA (zeige RHOA Proteine)-independent pathways.
The increase in LARG expression was accompanied by a significant increase in ACh (zeige FGFR3 Proteine)-stimulated Rho kinase (zeige ROCK2 Proteine) and ZIP kinase (zeige DAPK3 Proteine) activities, and sustained muscle contraction
PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.
LARG is activated by the Src family tyrosine kinase Fyn, whereas GEF-H1 catalytic activity is enhanced by ERK downstream of a signalling cascade that includes FAK and Ras
new insight into the mechanism by which p115RhoGEF (zeige ARHGEF1 Proteine) is activated by Galpha (zeige SUCLG1 Proteine)(13).
S1PR2 (zeige S1PR2 Proteine)-dependent activation of RhoA (zeige RHOA Proteine) in smooth muscle cells is mediated by LARG and that this signaling mechanism promotes the differentiated SMC (zeige DYM Proteine) phenotype.
cDNA of LARG (leukemia-associated guanine nucleotide exchange factor) was identified, and its gene expression was observed to be downregulated under clinorotation, which subsequently resulted in the repression of RhoA (zeige RHOA Proteine) activation
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
guanine nucleotide exchange factor
, Rho guanine nucleotide exchange factor (GEF) 12
, rho guanine nucleotide exchange factor 12-like
, leukemia-associated RhoGEF
, leukemia-associated rho guanine nucleotide exchange factor
, rho guanine nucleotide exchange factor 12
, leukemia-associated Rho guanine-nucleotide exchange factor
, leukemia-associated Rho guanine nucleotide exchange factor