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anti-Human ARHGEF12 Antikörper:
anti-Mouse (Murine) ARHGEF12 Antikörper:
anti-Rat (Rattus) ARHGEF12 Antikörper:
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We studied the function of LARG in murine and human megakaryocytes and platelets with Larg knockout (KO), shRNA-mediated knockdown and small molecule-mediated inhibition. We found that LARG is important for human, but not murine, megakaryocyte maturation.
that leukemia-associated Rho guanine-nucleotide exchange factor can be directly phosphorylated by cyclin-dependent kinase 1 (zeige CDK1 Antikörper)
Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF (zeige ARHGEF11 Antikörper) and leukemia-associated RhoGEF (LARG), use their PDZ (zeige INADL Antikörper) domains to bind class B plexins and play critical roles in signaling.
this study identified a novel association between IOP and ARHGEF12.
TGF-beta (zeige TGFB1 Antikörper) regulates LARG and GEF-H1 (zeige ARHGEF2 Antikörper) during epithelial-mesenchymal transition to affect stiffening response to force and cell invasion.
LARG is a novel and temporally distinct Rho Guanine Nucleotide Exchange Factor (zeige ARHGEF28 Antikörper) required for completion of abscission.
Data indicate that ICAM-1 (zeige ICAM1 Antikörper) signaling activates leukemia-associated Rho guanine nucleotide exchange factor (LARG), also known as Rho GEF (zeige SLC2A4RG Antikörper) 12 (ARHGEF12).
Agonist-induced Ca2 (zeige CA2 Antikörper)+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
RhoGEF (zeige ARHGEF11 Antikörper) activity of p210 (zeige EVPL Antikörper) BCR/ABL (zeige ABL1 Antikörper) directly contributes to transforming activity, and may account for the difference in disease outcome associated with p190 (zeige CNTNAP1 Antikörper) BCR/ABL (zeige ABL1 Antikörper) and p210 (zeige EVPL Antikörper) BCR/ABL (zeige ABL1 Antikörper).
NIS enhanced cell migration and invasion by binding to leukemia-associated RhoA (zeige RHOA Antikörper) guanine exchange factor
Data found an inverse relationship between the expression of miR (zeige MLXIP Antikörper)-660 and ARHGEF12 in both gain- and loss-of-function studies: overexpression of miR (zeige MLXIP Antikörper)-660 declined the mRNA and protein expressions of ARHGEF12 in C2C12 cells differentiation; however, knockdown of miR (zeige MLXIP Antikörper)-660 had completely opposite results.
This study demonstrated an almost 100-fold higher agonist sensitivity of the Galpha13 (zeige GNA13 Antikörper) LARG interaction compared to the Galpha13 (zeige GNA13 Antikörper) activation in the absence of LARG.
LARG may play a housekeeper role in regulating constitutive RhoA (zeige RHOA Antikörper) activity. Its role in regulating platelet function may principally be through RhoA (zeige RHOA Antikörper)-independent pathways.
The increase in LARG expression was accompanied by a significant increase in ACh (zeige FGFR3 Antikörper)-stimulated Rho kinase (zeige ROCK2 Antikörper) and ZIP kinase (zeige DAPK3 Antikörper) activities, and sustained muscle contraction
PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.
LARG is activated by the Src family tyrosine kinase Fyn, whereas GEF-H1 catalytic activity is enhanced by ERK downstream of a signalling cascade that includes FAK and Ras
new insight into the mechanism by which p115RhoGEF (zeige ARHGEF1 Antikörper) is activated by Galpha (zeige SUCLG1 Antikörper)(13).
S1PR2 (zeige S1PR2 Antikörper)-dependent activation of RhoA (zeige RHOA Antikörper) in smooth muscle cells is mediated by LARG and that this signaling mechanism promotes the differentiated SMC (zeige DYM Antikörper) phenotype.
cDNA of LARG (leukemia-associated guanine nucleotide exchange factor) was identified, and its gene expression was observed to be downregulated under clinorotation, which subsequently resulted in the repression of RhoA (zeige RHOA Antikörper) activation
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
guanine nucleotide exchange factor
, Rho guanine nucleotide exchange factor (GEF) 12
, rho guanine nucleotide exchange factor 12-like
, leukemia-associated RhoGEF
, leukemia-associated rho guanine nucleotide exchange factor
, rho guanine nucleotide exchange factor 12
, leukemia-associated Rho guanine-nucleotide exchange factor
, leukemia-associated Rho guanine nucleotide exchange factor