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LncRNA GHET1 was intimately involved in the occurrence and development of HCC (zeige FAM126A Proteine) through regulating ATF1.
a breakpoint in the EWSR1 (zeige EWSR1 Proteine)-ATF1 fusion to be the same as that reported in HCCC. Established CCOC-T cells grew extremely slowly, but the cells showed highly invasive activity
Pin1 (zeige PIN1 Proteine) is a novel regulator of ATF1 at Thr184.
Case Reports: maxillary sinus clear cell carcinomas with EWSR1 (zeige EWSR1 Proteine)-ATF1 gene fusion.
Results expand the spectrum of tumor types harboring EWSR1 (zeige EWSR1 Proteine)/FUS (zeige FUS Proteine)-ATF1 gene fusions to include a subgroup of conventional epithelioid malignant mesothelioma.
Report a distinct group of myxoid mesenchymal neoplasms occurring in children or young adults with a predilection for intracranial locations with EWSR1 (zeige EWSR1 Proteine)-AFT1/CREB1 (zeige CREB1 Proteine)/CREM (zeige CREM Proteine) fusions.
our results demonstrated that miR (zeige MLXIP Proteine)-30a may modulate the radiosensitivity of non-small cell lung cancer (NSCLC) through reducing the function of ATF1 in phosphorylation of ATM (zeige ATM Proteine) and have potential therapeutic value.
genetic association studies in a population in China: Data suggest that an SNP in ATF1 (rs11169571) is associated with essential hypertension in the population studied; altered binding of microRNA-1283 appears to be involved.
EWSR1 (zeige EWSR1 Proteine)-ATF1 fusion gene was found in hyalinizing clear cell carcinoma
Heme activates the ATF1 pathway in human macrophages via AMPK (zeige PRKAA1 Proteine), and that a similar response occurs after treatment of cells with metformin.
The current data shows a timely GFP translation in bovine embryos depending on sequences in the 3'UTR of ATF1/2, and indicates a difference between short and long isoforms.
the HSF1 (zeige HSF1 Proteine) complex, including BRG1 (zeige SMARCA4 Proteine) and lysine acetyltransferases p300 (zeige NOTCH1 Proteine) and CREB-binding protein (CBP (zeige CREBBP Proteine)), is formed in a manner dependent on the phosphorylation of ATF1
conclude that HO-1 (zeige HMOX1 Proteine) regulates DC maturation and function by modulating the p38 MAPK (zeige MAPK14 Proteine)-CREB (zeige CREB1 Proteine)/ATF1 signaling axis
Dehydroepiandrosterone sulfate (DHEAS (zeige SULT2A1 Proteine))-induced signaling is mediated through interaction with a membrane-bound G-protein-coupled receptor (zeige GPR34 Proteine), since silencing of Gnalpha11 leads to the abolition of the DHEAS (zeige SULT2A1 Proteine)-induced stimulation of Erk1/2, ATF-1, and CREB (zeige CREB1 Proteine).
indicate that dysregulation of p38 MAPK (zeige MAPK14 Proteine)-CREB (zeige CREB1 Proteine)/ATF1 signaling axis underlies the altered function and phenotype in Nrf2 (zeige NFE2L2 Proteine)-deficient DCs
Forced expression of EWS/ATF1 resulted in the development of EWS/ATF1-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1-driven transformation.
miR (zeige MLXIP Proteine)-34c functions, at least partially, by targeting the ATF1 gene in germ cell apoptosis, providing a novel mechanism with involvement of miRNA in the regulation of germ cell apoptosis.
ATF1 is a novel substrate of RSK2 (zeige RPS6KA3 Proteine) and that RSK2 (zeige RPS6KA3 Proteine)-ATF1 signaling plays an important role in EGF (zeige EGF Proteine)-induced neoplastic cell transformation.
study demonstrates a role for trophic signaling and constitutive activation of activating transcription factor 1(Atf1) and cAMP response element-binding protein (CREB) at the time of zygotic genome activation
MSK1 (zeige RPS6KA5 Proteine) and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB (zeige CREB1 Proteine) and ATF1 in fibroblasts.
phosphorylation by the ERK MAPK (zeige MAPK1 Proteine) pathway is required for epidermal growth factor (zeige EGF Proteine)-induced c-jun (zeige JUN Proteine) expression
Data indicate increasing expression for CREB (zeige CREB1 Proteine), ATF1, and ATF3 (zeige ATF3 Proteine) during gastrulation.
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.
activating transcription factor 1
, cyclic AMP-dependent transcription factor ATF-1
, cAMP-dependent transcription factor ATF-1