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These results show that b-arrestin1 (zeige SAG Proteine) and b-arrestin2 exert differential actions on PAC1R internalization and PAC1R-dependent ERK1/2 activation, and suggest that the two b-arrestin (zeige SAG Proteine) isoforms may be involved in fine and precise tuning of the PAC1R signaling pathways.
These results provide evidence for an association between ADCYAP1R1 and PTSD and indicate that there may indeed be sex differences.
These findings lead to a model in which E2 induces the expression of ADCYAP1R1 through binding of ERalpha (zeige ESR1 Proteine) at the ERE as an adaptive response to stress. Inhibition of E2/ERalpha (zeige ESR1 Proteine) binding to the ERE containing the rs2267735 risk allele results in reduced expression of ADCYAP1R1, diminishing estrogen regulation as an adaptive stress response and increasing risk for PTSD.
Data suggest that GCGR (glucagon receptor (zeige GCGR Proteine)) activation proceeds via a mechanism in which transmembrane helix 6 (TM6) is held in an inactive conformation by a conserved polar core and a hydrophobic lock (involving intracellular loop 3, IC3); mutations in the corresponding polar core of GCGR (zeige GCGR Proteine) or PAC1R disrupt these inhibitory elements, allow TM6 to swing outward, and induce constitutive G protein signaling.
Results confirmed for the first time that doxycycline specially targeted pituitary adenylate cyclase-activating polypeptide (PACAP (zeige ADCYAP1 Proteine)) receptor type 1 (PAC1) imitating PACAP (zeige ADCYAP1 Proteine)(30-37) and acted as an enhancer by facilitating the subsequent ligand binding and the activation of PAC1.
Data show that glucocorticoid response genes NR3C1 (zeige NR3C1 Proteine), ADCYAP1R1 and HSD11B2 (zeige HSD11B2 Proteine) were relatively hypomethylated whereas FKBP5 (zeige FKBP5 Proteine) was hypermethylated.
High child stress and an ADCYAP1R1 single-nucleotide polymorphism are associated with reduced bronchodilator response in children with asthma.
and its receptor (PAC1) are involved in stress response and anxiety.
PAC1/PACAP (zeige ADCYAP1 Proteine) receptor endocytosis contributes to ERK (zeige EPHB2 Proteine) acktivation.
Individual differences in ADCYAP1R1 genotype may contribute to dysregulated fear circuitry known to play a central role in posttraumatic stress disorder and other anxiety disorders.
PACAP (zeige ADCYAP1 Proteine)/PAC1 signaling is important for light regulated behavior, VIP (zeige Vip Proteine)/VPAC2 (zeige VIPR2 Proteine) signaling for stable clock function and both signaling pathways may play a role in shaping diurnality versus nocturnality.
The results suggested that sympathetic nerve innervation may be responsible for Pituitary adenylate cyclase-activating polypeptide (zeige ADCYAP1 Proteine)-regulated hematopoiesis in bone marrow, mainly via PAC1.
PACAP (zeige ADCYAP1 Proteine)/PAC1 signaling has a role in light regulated food anticipatory activity
PAC1 plays a prominent role in chronic restraint stress response, but less so in the acute restraint stress response.
overexpression of Pac1 rescued the Zac1 (zeige PLAGL1 Proteine) knockdown neuronal migration phenotype
PAC1 has ligand-independent and dimer-dependent intrinsic/basal activity, conferring cells with anti-apoptotic activities against serum withdrawal, which is involved in the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signal and is associated with the endocytosis of PAC1 dimers.
PACAP (zeige ADCYAP1 Proteine) and PAC1-R expression increased in cumulus cells isolated at different times after treatment with human chorionic gonadotropin.
These results suggest that Sp1 (zeige SP1 Proteine) cross-linking might be crucial in negative regulation of PAC1 gene expression due to TG2 (zeige TGM2 Proteine) in OGD (zeige FGFR1 Proteine)-induced ER stress.
This study demonistrated that pac1r expression in reactive astrocytes induced by global brain ischemia in mice.
PAC1R mRNA expression in the hippocampus was significantly elevated on day 7 after ischemia induced by bilateral common carotid artery occlusion. .
These results suggest that, in fish, PACAP (zeige VIPR2 Proteine) and PAC1-R may play a role in brain development.
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
PACAP receptor 1
, PACAP type I receptor
, pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop
, pituitary adenylate cyclase-activating polypeptide type I receptor
, type I adenylate cyclase activating polypeptide receptor
, PACAP type IA receptor
, adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
, adenylate cyclase activating polypeptide 1 type 1 receptor
, pituitary adenylate cyclase activating polypeptide 1 receptor (1)
, pituitary adenylate cyclase activating polypeptide receptor
, pituitary adenylate cyclase-activating polypeptide type IA receptor
, PAC1 receptor
, adenylate cyclase activating polypeptide 1 receptor 1
, pituitary adenylate cyclase activating polypeptide 1 receptor