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These findings lead to a model in which E2 induces the expression of ADCYAP1R1 through binding of ERalpha (zeige ESR1 ELISA Kits) at the ERE as an adaptive response to stress. Inhibition of E2/ERalpha (zeige ESR1 ELISA Kits) binding to the ERE containing the rs2267735 risk allele results in reduced expression of ADCYAP1R1, diminishing estrogen regulation as an adaptive stress response and increasing risk for PTSD.
Data suggest that GCGR (glucagon receptor (zeige GCGR ELISA Kits)) activation proceeds via a mechanism in which transmembrane helix 6 (TM6) is held in an inactive conformation by a conserved polar core and a hydrophobic lock (involving intracellular loop 3, IC3); mutations in the corresponding polar core of GCGR (zeige GCGR ELISA Kits) or PAC1R disrupt these inhibitory elements, allow TM6 to swing outward, and induce constitutive G protein signaling.
Results confirmed for the first time that doxycycline specially targeted pituitary adenylate cyclase-activating polypeptide (PACAP (zeige ADCYAP1 ELISA Kits)) receptor type 1 (PAC1) imitating PACAP (zeige ADCYAP1 ELISA Kits)(30-37) and acted as an enhancer by facilitating the subsequent ligand binding and the activation of PAC1.
Data show that glucocorticoid response genes NR3C1 (zeige NR3C1 ELISA Kits), ADCYAP1R1 and HSD11B2 (zeige HSD11B2 ELISA Kits) were relatively hypomethylated whereas FKBP5 (zeige FKBP5 ELISA Kits) was hypermethylated.
High child stress and an ADCYAP1R1 single-nucleotide polymorphism are associated with reduced bronchodilator response in children with asthma.
and its receptor (PAC1) are involved in stress response and anxiety.
PAC1/PACAP (zeige ADCYAP1 ELISA Kits) receptor endocytosis contributes to ERK (zeige EPHB2 ELISA Kits) acktivation.
Individual differences in ADCYAP1R1 genotype may contribute to dysregulated fear circuitry known to play a central role in posttraumatic stress disorder and other anxiety disorders.
Data indicate that VIP (zeige Vip ELISA Kits) and PACAP (zeige ADCYAP1 ELISA Kits) increased macrophage resistance to HIV-1 replication by inducing the synthesis of beta-chemokines CCL3 (zeige CCL3 ELISA Kits) and CCL5 (zeige CCL5 ELISA Kits) and IL-10 (zeige IL10 ELISA Kits) following preferential activation of the receptors VPAC2 (zeige VIPR2 ELISA Kits) and PAC1.
The findings suggest that the PACAP (zeige ADCYAP1 ELISA Kits)-PAC1 receptor pathway may play an important role in female human responses to traumatic stress
The results suggested that sympathetic nerve innervation may be responsible for Pituitary adenylate cyclase-activating polypeptide (zeige ADCYAP1 ELISA Kits)-regulated hematopoiesis in bone marrow, mainly via PAC1.
PACAP (zeige ADCYAP1 ELISA Kits)/PAC1 signaling has a role in light regulated food anticipatory activity
PAC1 plays a prominent role in chronic restraint stress response, but less so in the acute restraint stress response.
overexpression of Pac1 rescued the Zac1 (zeige PLAGL1 ELISA Kits) knockdown neuronal migration phenotype
PAC1 has ligand-independent and dimer-dependent intrinsic/basal activity, conferring cells with anti-apoptotic activities against serum withdrawal, which is involved in the Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signal and is associated with the endocytosis of PAC1 dimers.
PACAP (zeige ADCYAP1 ELISA Kits) and PAC1-R expression increased in cumulus cells isolated at different times after treatment with human chorionic gonadotropin.
These results suggest that Sp1 (zeige SP1 ELISA Kits) cross-linking might be crucial in negative regulation of PAC1 gene expression due to TG2 (zeige TGM2 ELISA Kits) in OGD (zeige FGFR1 ELISA Kits)-induced ER stress.
This study demonistrated that pac1r expression in reactive astrocytes induced by global brain ischemia in mice.
PAC1R mRNA expression in the hippocampus was significantly elevated on day 7 after ischemia induced by bilateral common carotid artery occlusion. .
PAC1R transcript expression exhibited differential responses in NGF (zeige NGFB ELISA Kits)-OE mice that were tissue (urothelium vs. detrusor) cyclophosphamide-induced-cystitis duration-dependent.
These results suggest that, in fish, PACAP (zeige VIPR2 ELISA Kits) and PAC1-R may play a role in brain development.
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
PACAP receptor 1
, PACAP type I receptor
, pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop
, pituitary adenylate cyclase-activating polypeptide type I receptor
, type I adenylate cyclase activating polypeptide receptor
, PACAP type IA receptor
, adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
, adenylate cyclase activating polypeptide 1 type 1 receptor
, pituitary adenylate cyclase activating polypeptide 1 receptor (1)
, pituitary adenylate cyclase activating polypeptide receptor
, pituitary adenylate cyclase-activating polypeptide type IA receptor
, PAC1 receptor
, adenylate cyclase activating polypeptide 1 receptor 1
, pituitary adenylate cyclase activating polypeptide 1 receptor