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anti-Human AATF Antikörper:
anti-Mouse (Murine) AATF Antikörper:
anti-Rat (Rattus) AATF Antikörper:
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Human Polyclonal AATF Primary Antibody für IP, PLA - ABIN188634
Moore, Bai, Boisvert, Latonen, Rantanen, Simpson, Pepperkok, Lamond, Laiho: Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation. in Molecular & cellular proteomics : MCP 2011
Human Polyclonal AATF Primary Antibody für ICC, IF - ABIN4277115
Fagerberg, Stadler, Skogs, Hjelmare, Jonasson, Wiking, Abergh, Uhlén, Lundberg: Mapping the subcellular protein distribution in three human cell lines. in Journal of proteome research 2011
Results show that Che-1 (zeige BCHE Antikörper) protects colon cancer cells from apoptosis induced by hypoxia through its ability to regulate HIF1-alpha (zeige HIF1A Antikörper) stabilization in colorectal cancer cells.
Results show that eEF1Bgamma binds to the Che-1 promoter region and its transcript, and describe a novel mitochondrial localization for the Che-1 protein which needs mitochondrial integrity for correct localization.
we identified the ANN complex as a novel functional module supporting the nucleolar maturation of 40S ribosomal subunits. Our data help to explain the described role of AATF in cell proliferation during mouse development as well as its requirement for malignant tumor growth.
the effect of APOBEC3G (zeige APOBEC3G Antikörper) over-expression upon AATF gene expression, was examined.
loss of Che-1 (zeige BCHE Antikörper) inhibits proliferation and promotes apoptosis in MG-63 cells by decreasing the level of mutant p53 (zeige TP53 Antikörper)
It was concluded that PARP-1 (zeige PARP1 Antikörper) was involved in the DNA damage repair induced by HQ via increasing the accumulation of apoptosis antagonizing transcription factor through PARylation.
These results confirm Che-1 as an important regulator of p53 activity and suggest Che-1 to be a promising yet attractive drug target for cancer therapy.
In the face of high glucose threat, mitochondrial UCP2 (zeige UCP2 Antikörper) gene expression is regulated by miR (zeige MLXIP Antikörper)-2909 and AATF.
This mutant AATF along with its interactome consisting of SP1 (zeige PSG1 Antikörper), DNMT3B (zeige DNMT3B Antikörper) and Par-4 (zeige PAWR Antikörper) ensures cancer cell DNA methylation (zeige HELLS Antikörper) required for down-regulation of tumor suppressor genes.
HIPK2 depletion strongly decreases Che-1 ubiquitylation and degradation.
we found that object recognition memory persistence at 7days was impaired in Che-1(+/-) heterozygous mice. This is the first evidence showing that Che-1 is involved in memory processes.
These results identify AATF as a nucleolar-confined c-Jun (zeige JUN Antikörper) cofactor whose expression levels and spatial distribution determine the stress-induced activity of c-Jun (zeige JUN Antikörper) and the levels of c-Jun (zeige JUN Antikörper)-mediated apoptosis.
AATF is an endogenous antagonist of Par-4 (zeige F2RL3 Antikörper) activity and an effective inhibitor of aberrant amyloid beta 1-42 production and secretion under apoptotic conditions.
Che-1 as a new Pin1 (zeige PIN1 Antikörper) and HDM2 target and confirm its important role in the cellular response to DNA damage.
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.
apoptosis antagonizing transcription factor
, protein AATF
, Apoptosis antagonizing transcription factor
, protein AATF-like
, apoptosis-antagonizing transcription factor
, rb-binding protein Che-1
, traube protein