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Human SNAI1 ELISA Kit für Cell ELISA - ABIN2114948
Mikuła-Pietrasik, Sosińska, Maksin, Kucińska, Piotrowska, Murias, Woźniak, Szpurek, Książek: Colorectal cancer-promoting activity of the senescent peritoneal mesothelium. in Oncotarget 2015
Human SNAI1 ELISA Kit für Sandwich ELISA - ABIN1118176
Abdelmageed, El-Naga, El-Demerdash, Elmazar: Indole-3- carbinol enhances sorafenib cytotoxicity in hepatocellular carcinoma cells: A mechanistic study. in Scientific reports 2016
Disruption of Snail expression in follicle stem cells compromises proliferation, but not maintenance. FSCs with excessive Snail expression had increased proliferation and lifespan, accompanied by a moderate decrease inE-cadherin expression (required for adhesion of FSCs to their niche) at the junction between their adjacent cells, indicating a conserved role of Snail in E-cadherin (zeige CDH1 ELISA Kits) inhibition.
during gastrulation of Drosophila embryos, Sna expression downregulates polarity protein Baz which in turn results in junction disassembly at protein levels.
evidence for mechanosensitivity of cell-cell junctions and implications that myosin-mediated tension can prevent Snail-driven Eepithelial-mesenchymal transitions
Snail can potentiate enhancer activation by collaborating with different activators, providing a new mechanism by which Snail regulates development.
Rapid transcription kinetics and negative autoregulation are responsible for the remarkable homogeneity of snail expression and the coordination of mesoderm invagination.
Study shows that Sna represses transcription of pbl in the mesoderm primordium of D. melanogaster via one or more Sna-binding sites, which are conserved among species of the Drosophila genus, but not in the mosquito, correlating with the different modes of gastrulation in the different genuses.
Complex interactions between cis (zeige CISH ELISA Kits)-regulatory modules in native conformation are critical for Drosophila snail expression.
The Snail repressor positions Notch (zeige NOTCH1 ELISA Kits) signaling in the Drosophila embryo.
results show that Sna has a positive regulatory function on sim (zeige SIM2 ELISA Kits) expression in the presumptive mesectoderm; this positive effect of Sna depends on the Su(H (zeige RBPJ ELISA Kits))-binding sites within the sim (zeige SIM2 ELISA Kits) promoter, suggesting that Sna regulates Notch (zeige NOTCH1 ELISA Kits) signaling
snail is required for Drosophila gastrulation and is not replaceable by Escargot or Worniu.
The transcription factor Snail1 is essential for tissue separation, enabling paraxial protocadherin (PAPC (zeige PCDH8 ELISA Kits)) to promote tissue separation through novel functions.
Interaction with Snail1/2, and Twist function more generally, is regulated by GSK-3-beta (zeige GSK3b ELISA Kits)-mediated phosphorylation of conserved sites in the WR domain.
the same E3 ubiquitin ligase known to regulate Snail family proteins, Partner of paired (Ppa (zeige FBXL14 ELISA Kits)), also controlled Twist stability and did so in a manner dependent on the Twist WR-rich domain
PARP3 (zeige PARP3 ELISA Kits) controls of TGFbeta (zeige TGFB1 ELISA Kits)-induced epithelial mesenchymal transformation and acquisition of stem-like cell features by stimulation transglutaminase 2 (zeige TGM2 ELISA Kits)/SNAI1 signaling.
Results show that Snai1 binds to the PXDN (zeige PXDN ELISA Kits) promoter in response to TGF-beta1 (zeige TGFB1 ELISA Kits) treatment of cervical carcinoma cell lines and represses its expression.
increased Snail expression during progression to metastatic disease may prime cells for resistance to AR-targeted therapies by promoting AR activity in prostate cancer
Snail1 may be a co-factor of TERT (zeige TERT ELISA Kits) enhancer rs2853677 for predicting lung adenocarcinoma susceptibility and prognosis
Snail-1 might play an important role in the progression of bladder cancer
Study demonstrated in human breast cancer samples that MDM2 (zeige MDM2 ELISA Kits) induces epithelial-to-mesenchymal transition by enhancing Snail expression in vitro and in vivo.
Amla extract (Emblica officinalis, AE) decreases the gene and protein expression of IGF1R (zeige IGF1R ELISA Kits), a target of miR (zeige MLXIP ELISA Kits)-375, and SNAIL1, a transcription factor that represses E-cadherin (zeige CDH1 ELISA Kits) expression.
The results demonstrate that knockdown of Snail can inhibit the inhibits epithelial-mesenchymal transition process of laryngeal squamous cell carcinoma cells through the vitamin D receptor (zeige VDR ELISA Kits) signaling pathway in vitro.
By repressing FOXA family members, SNAIL1 targets transcription factors at strategically important positions in gene-regulatory hierarchies, which may facilitate transcriptional reprogramming during EMT (zeige ITK ELISA Kits).
Results show that Snail is a direct target of miR (zeige MLXIP ELISA Kits)-137 and miR (zeige MLXIP ELISA Kits)-34a in ovarian cancer cells.
a Snail1-ATGL (zeige PNPLA2 ELISA Kits) axis that regulates adipose lipolysis and fatty acid release, is reported.
A20 (zeige TNFAIP3 ELISA Kits) promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1.
Metagenomic analysis revealed direct correlation between PPARGC1A (zeige PPARGC1A ELISA Kits), SNAI1, and metastatic lung disease.
both Snail and Slug are able to form binary complexes with either YAP (zeige YAP1 ELISA Kits) or TAZ (zeige TAZ ELISA Kits) that, together, control YAP (zeige YAP1 ELISA Kits)/TAZ (zeige TAZ ELISA Kits) transcriptional activity and function throughout mouse development.
results demonstrate that skeletal stem/stromal cell mobilize Snail/Slug-YAP (zeige YAP1 ELISA Kits)/TAZ (zeige TAZ ELISA Kits) complexes to control stem cell function
these results might suggest that calcineurin inhibitor (zeige RCAN1 ELISA Kits)-induced tubular SNAI1 protein cytoplasmic accumulation, possibly because of impaired SNAI1 proteasomal degradation and nuclear translocation, might be a sign of a diseased profibrotic epithelial phenotype.
Snail1 as a molecular bypass that suppresses the anti-proliferative and pro-apoptotic effects exerted by wild-type p53 (zeige TP53 ELISA Kits) in breast cancer
Snail1 deficiency modified the phenotype of pancreatic tumors .
miR (zeige MLXIP ELISA Kits)-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the Zeb2 (zeige ZEB2 ELISA Kits) and Snail1 transcriptional repressor complexes, such as Smad2 (zeige SMAD2 ELISA Kits) and Smad5 (zeige SMAD5 ELISA Kits).
show that Snail1-induced fibrosis can be reversed in vivo and that obstructive nephropathy can be therapeutically ameliorated in mice by targeting Snail1 expression
The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2.
snail homolog 1
, snail like protein
, Protein snail-like protein 1
, snail homolog 1 (Drosophila)
, snail 1 homolog
, zinc-finger transcription factor Snail
, protein Xsnail
, protein snail homolog Sna
, protein xSna
, snail protein
, zinc finger protein with snail domain similar to escargot
, transcription factor protein
, snail zinc finger protein
, snail-like protein 1
, protein sna
, protein snail homolog 1
, snail 1 zinc finger protein
, snail 1, zinc finger protein
, zinc finger protein SNAI1