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Mouse (Murine) Polyclonal PDE8B Primary Antibody für WB - ABIN1881646
Horvath, Faucz, Finkielstain, Nikita, Rothenbuhler, Almeida, Mericq, Stratakis: Haplotype analysis of the promoter region of phosphodiesterase type 8B (PDE8B) in correlation with inactivating PDE8B mutation and the serum thyroid-stimulating hormone levels. in Thyroid : official journal of the American Thyroid Association 2010
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replication confirmed at genome-wide significance the association of loci at FOXE1 with hypothyroidism, and PDE8B, CAPZB and PDE10A with serum TSH. A total of 12 SNPs seemed to explain nearly 7% of the serum TSH variation
a heterozygous nonsense mutation in the first exon of cyclic nucleotide phosphodiesterase (zeige PDE3B Antikörper) 8B gene, which is predicted to disrupt all important functional domains of the cyclic nucleotide phosphodiesterase (zeige PDE3B Antikörper) 8B protein, in two members of family with autosomal-dominant striatal degeneration
Genetic variation of the PDE8B gene may be involved in the etiology of subclinical hypothyroidism in pregnant women.
A prevalence of the minor allele of PDE8B gene polymorphism associated with elevated serum levels of TSH was demonstrated in patients affected by sporadic nonautoimmune subclinical hypothyroidism.
rs4704397 in phosphodiesterase 8B is associated with thyrotropin and thyroid hormone (zeige PTH Antikörper) concentrations
There is an association between homozygous A/A as well as homozygous G/G carriers of SNP rs 4704397 in PDE8B and recurrent miscarriage.
PDE8B gene polymorphisms may be correlated with hyperthyroxinemia in the Chinese Han population.
PDE8B is another PDE (zeige ALDH7A1 Antikörper) gene in which variations may contribute to predisposition of adrenocortical tumours.
In obese children, PDE8B is associated with TSH; the interaction between adiposity and PDE8B on TSH is not synergistic, but follows an additive model.
Common genetic variation in PDE8B is associated with reciprocal changes in thyroid hormone (zeige PTH Antikörper) levels.
Pde8b knockout mice demonstrate improvement in select behaviors, motor-coordination, attenuation of age-induced motor coordination decline and increased anxiety levels.
findings suggest that both PDE8A (zeige PDE8A Antikörper) and PDE8B play essential roles to maintain low cAMP levels, thereby suppressing resting steroidogenesis by keeping CEH (zeige EPHX2 Antikörper)/HSL (zeige LIPE Antikörper) inactive and StAR protein expression low
Phosphodiesterase 8B is a major regulator of pools of cyclic AMP (zeige TMPRSS5 Antikörper) that promote steroidogenesis.
The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.
, high-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
, high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B-like
, 3',5' cyclic nucleotide phosphodiesterase 8B
, cell proliferation-inducing gene 22 protein
, high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
, cAMP-specific cyclic nucleotide phosphodiesterase PDE8