anti-Follistatin (FST) Antikörper

Fruit Fly (Drosophila melanogaster) Follistatin (FST) Interaktionspartner

1. FS proteins may also function in facilitating ligand diffusion. We find that mutants of daw are rescued in significant numbers by expression of vertebrate follistatin (FS) proteins

Human Follistatin (FST) Interaktionspartner

1. Surface plasmon resonance analysis showed no significant association between FS288 and AMHC (zeige MYH6 Antikörper) , suggesting that FS288 indirectly regulates AMH (zeige AMH Antikörper) signaling. Activin A (zeige INHBA Antikörper), a direct target of FS288, did not itself induce reporter activity in P19 (zeige CDKN2D Antikörper) cells, but did prevent the FS288-induced increase in AMH (zeige AMH Antikörper) signaling. Hence, local concentrations of FS288 and Activin A (zeige INHBA Antikörper) may influence the response of some cell types to AMH (zeige AMH Antikörper).

2. results suggest a role for FST as a suppressor of invasion and metastasis in breast cancer

3. These data indicate that FST is a bona fide metastasis suppressor in this mouse model and support future efforts to develop an FST mimetic to suppress metastatic progression.

4. These findings indicate that muscle-specific (zeige EIF3K Antikörper) Fst overexpression in pigs enhances skeletal muscle growth, at least partly due to myofiber hypertrophy and providing a promising approach to increase muscle mass in pigs and other livestock.

5. High follistatin expression is associated with lung adenocarcinoma.

6. FST and KLK6 (zeige KLK1 Antikörper) may have significance in breast cancer detection

7. Follistatin and activin A (zeige INHBA Antikörper) are higher in MI than in CAD (zeige CAD Antikörper) suggesting increased release due to myocardial necrosis. They can predict MI with accuracy similar to CK-MB

8. The activin-A (zeige INHBA Antikörper) to follistatin ratio may play a role in determining the clinical phenotype of preterm birth as preterm labor or preterm premature rupture of membranes.

9. Low follistatin expression is associated with liver cirrhosis.

10. Follistatin levels are associated with circulating leptin (zeige LEP Antikörper) levels and display a day-night rhythm and a menstrual cycle, but not a seasonal, variation.

Pig (Porcine) Follistatin (FST) Interaktionspartner

1. Response to selection for increased litter size could not be attributed to effects at the estrogen receptor (zeige ESR1 Antikörper), retinol-binding protein or follistatin loci.

Cow (Bovine) Follistatin (FST) Interaktionspartner

1. Data suggest that SMAD4 (SMAD family member 4 (zeige SMAD4 Antikörper)) mRNA is increased in oocytes during maturation, is maximal in 2-cell blastocysts, remains elevated through 8-cell stage, and then decreases; embryotrophic actions of FST are SMAD4 (zeige SMAD4 Antikörper) dependent.

2. The expression of the components of the activin (zeige Actbeta Antikörper)-inhibin-follistatin system is altered in bovine cystic ovarian disease.

3. A functional role for oocyte-derived follistatin in bovine early embryogenesis.

Mouse (Murine) Follistatin (FST) Interaktionspartner

1. Surface plasmon resonance analysis showed no significant association between FS288 and AMHC (zeige MYH6 Antikörper) , suggesting that FS288 indirectly regulates AMH (zeige AMH Antikörper) signaling. Activin A (zeige INHBA Antikörper), a direct target of FS288, did not itself induce reporter activity in P19 (zeige CDKN2D Antikörper) cells, but did prevent the FS288-induced increase in AMH (zeige AMH Antikörper) signaling. Hence, local concentrations of FS288 and Activin A (zeige INHBA Antikörper) may influence the response of some cell types to AMH (zeige AMH Antikörper).

2. Hypergravity affects follistatin levels in muscle through the vestibular system in mice. Follistatin may play some roles in the interactions between muscle and bone metabolism in response to gravity change.

3. Fst promotes brown adipocyte characteristics in both white adipose tissue and brown adipose tissue depots in vivo through distinct mechanisms.

4. Results showed activin (zeige Actbeta Antikörper)-C and follistatin are differentially expressed during prostate development and suggested that the antagonistic property of follistatin is secondary to the action of activin (zeige Actbeta Antikörper)-C. Study provides evidence to support a role of activin (zeige Actbeta Antikörper)-C in prostate development and provides new insights in the spatiotemporal localization of activins and their antagonists during mouse prostate development.

5. Oviducts of tghFST315 mice failed to coil, the myometrium was disorganised, endometrial gland number was reduced and oviducts and uteri contained abundant leukocytes. These studies show that follistatin is crucial to postnatal oviductal-uterine development and function.

6. OVOL1 (zeige OVOL1 Antikörper)-regulated Fst and SFRP1 (zeige SFRP1 Antikörper) affect hair inductive potency of neonatal dermal cells.

7. This study assesses the regulation of activin A (zeige INHBA Antikörper) and follistatin in a murine myocardial ischaemia-reperfusion model.

8. Results implicate a role of follistatin (Fst) in the induction of brown adipocyte character and regulation of energy metabolism.

9. follistatin induces hair wave propagation and its level decreases in aging mice.

10. Follistatin aids in maintaining proper somite size, and consequently sclerotome progenitor numbers, by preventing paraxial mesoderm from adopting an intermediate/lateral plate mesodermal fate in the Noggin (zeige NOG Antikörper)-deficient state.

Zebrafish Follistatin (FST) Interaktionspartner

1. Roles of follistatin 1 in regulation of zebrafish fecundity and sexual differentiation.

2. Results suggest that Follistatin 1 overexpression can promote zebrafish muscle growth by enhancing myofiber hyperplasia.

3. Follistatin increased with growth of ovary. Increased significantly during vitellogenesis. Gradually increased during daily ovulatory cycle.

4. fst, a bone morphogenetic protein antagonist expressed in gastrulation, is dispensable for neural crest induction.