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Data suggest that Gpr176 (G-protein coupled receptor 176 (zeige GPR176 Proteine)) is an SCN (zeige SRI Proteine)-(suprachiasmatic nucleus-)enriched orphan GPCR (zeige NMUR1 Proteine) (G-protein-coupled receptor (zeige ADRA1A Proteine)) that sets the pace of circadian behavior; a unique cAMP-repressing G-protein subclass Gz is required for the activity of Gpr176 (zeige GPR176 Proteine). [REVIEW]
These results suggest that the expression of RGS20 may promote metastasis of tumor cells.
Findings suggest that high regulator of G protein signaling 20 (RGS20) expression is associated with unfavorable survival in triple-negative breast cancer (TNBC).
provide new evidence that RGSZ1 interacts not only with Galpha (zeige SUCLG1 Proteine)(z,) but also with Galpha (zeige SUCLG1 Proteine)(i), as supported by in vitro binding assays and functional studies
The major function of PKCI-1 (zeige HINT1 Proteine) is to modulate mu opioid receptor (zeige OPRM1 Proteine) signaling pathway along with RGSZ1, rather than directly mediating the Galphaz RGSZ1 interaction.
RGSz1 function suppression optimizes the actions of opioid analgesics by mechanisms that involve the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway
Analysis of in vitro microtubule polymerization/depolymerization showed that binding of RGSZ1 to SCG10 (zeige STMN2 Proteine) effectively blocked the ability of SCG10 (zeige STMN2 Proteine) to induce microtubule disassembly
The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, gz-selective GTPase-activating protein
, regulator of G-protein signaling 20 variant 2
, regulator of G-protein signaling Z1
, regulator of G-protein signalling 20
, regulator of Gz-selective protein signaling 1
, Gz-selective GTPase-activating protein
, Gz-specific GAP
, RGS protein Gz-GAP
, retina-specific regulator of G-protein signaling 1