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The abnormal social behaviors of Dio3 (zeige DIO3 Proteine)-/- mice were associated with sexually dimorphic alterations in the physiology of oxytocin (OXT) and arginine vasopressin (AVP (zeige AVP Proteine)), 2 neuropeptides with important roles in determining social interactions.
Activation of the oxytocin receptor (zeige OXTR Proteine) in brain regions facilitates social defeat posture.
the absence of OT leads to significant changes in the expression of the studied genes (OTR (zeige OXTR Proteine), ERalpha (zeige ESR1 Proteine), ERbeta (zeige ESR2 Proteine), V1aR (zeige AVPR1A Proteine)), and these changes may contribute to the decreased sexual behavior observed in OT gene knockout females.
These results reveal that Oxt protects pancreatic beta cells against death caused by metabolic stress, and Oxt signaling may be a potential therapeutic target.
CA3 (zeige CA3 Proteine) pyramidal cells in the adult mouse hippocampus express OXT receptors and receive inputs from hypothalamic OXT neurons.
These results identify G9a (zeige EHMT2 Proteine)-induced histone methylation at the OXT and AVP (zeige AVP Proteine) promoters in the Basolateral Amygdala as a mechanism for mediating stress-induced lasting behavioral depression and its reversal by exercise.
OXT was up-regulated in both hypothalamic magnocellular neurosecretory cells and parvocellular cells by chronic inflammation, and also that OXT in the PVN-spinal pathway may be involved in sensory modulation
Oxtr (zeige OXTR Proteine) signaling is crucial for entrainment of odor to social cues but is dispensable for entrainment to nonsocial cues. Oxt conveys saliency of social stimuli to sensory representations in the piriform cortex during odor-driven social learning.
Nos1 (zeige NOS1 Proteine) neurons of paraventricular nucleus of the hypothalamus promote negative energy balance through changes in feeding and energy expenditure, whereas OXT neurons regulate energy expenditure alone.
Data suggest that oxytocin plays a crucial role in the sexual behavior display, number of released oocytes and density of dendritic spines in the MePD (zeige THOP1 Proteine) of female mice without affecting AVP (zeige AVP Proteine) plasma concentration
Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Neurophysin 1 specifically binds oxytocin.
, oxytocin-neurophysin 1