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The abnormal social behaviors of Dio3 (zeige DIO3 Proteine)-/- mice were associated with sexually dimorphic alterations in the physiology of oxytocin (OXT) and arginine vasopressin (AVP (zeige AVP Proteine)), 2 neuropeptides with important roles in determining social interactions.
Activation of the oxytocin receptor (zeige OXTR Proteine) in brain regions facilitates social defeat posture.
the absence of OT leads to significant changes in the expression of the studied genes (OTR (zeige OXTR Proteine), ERalpha (zeige ESR1 Proteine), ERbeta (zeige ESR2 Proteine), V1aR (zeige AVPR1A Proteine)), and these changes may contribute to the decreased sexual behavior observed in OT gene knockout females.
These results reveal that Oxt protects pancreatic beta cells against death caused by metabolic stress, and Oxt signaling may be a potential therapeutic target.
CA3 (zeige CA3 Proteine) pyramidal cells in the adult mouse hippocampus express OXT receptors and receive inputs from hypothalamic OXT neurons.
These results identify G9a (zeige EHMT2 Proteine)-induced histone methylation at the OXT and AVP (zeige AVP Proteine) promoters in the Basolateral Amygdala as a mechanism for mediating stress-induced lasting behavioral depression and its reversal by exercise.
OXT was up-regulated in both hypothalamic magnocellular neurosecretory cells and parvocellular cells by chronic inflammation, and also that OXT in the PVN-spinal pathway may be involved in sensory modulation
Oxtr (zeige OXTR Proteine) signaling is crucial for entrainment of odor to social cues but is dispensable for entrainment to nonsocial cues. Oxt conveys saliency of social stimuli to sensory representations in the piriform cortex during odor-driven social learning.
Nos1 (zeige NOS1 Proteine) neurons of paraventricular nucleus of the hypothalamus promote negative energy balance through changes in feeding and energy expenditure, whereas OXT neurons regulate energy expenditure alone.
Data suggest that oxytocin plays a crucial role in the sexual behavior display, number of released oocytes and density of dendritic spines in the MePD (zeige THOP1 Proteine) of female mice without affecting AVP (zeige AVP Proteine) plasma concentration
Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1 (zeige IGF1 Proteine)/oxytocin system.
loop status modulates dimerization via long-range effects on neurophysin (zeige AVP Proteine) conformation involving neighboring Phe22 as a key intermediary
Intraluteal OXT may locally modulate secretion of vasoactive substances, particularly EDN1 (zeige EDN1 Proteine) and PGF (zeige PGF Proteine)(2alpha) within the corpus luteum.
A significant moderating effect of OXT genotype (rs2740210) on the relationship between social support and psychiatric distress was detected
These results suggest that OXT and OXTR (zeige OXTR Proteine) are controlled mainly by E2 in the placenta via ESR1 (zeige ESR1 Proteine) and thus may play physiological functions in the human placenta during the late stage of pregnancy.
Study found a higher expression of paraventricular nucleus OXT in the mood disorder patients than in the control subjects, and observed a clear co-localization of androgen receptor (zeige AR Proteine) in OXT-expressing neurons, both in the cytoplasm and in the nucleus. In addition, a significant decrease in OXT-mRNA levels was observed after pre-incubation of the SK-N-SH cells with testosterone.
Serum and prostatic oxytocin levels are increased in the PCa (zeige FLVCR1 Proteine) subjects. Serum oxytocin level may be a biomarker for PCa (zeige FLVCR1 Proteine) in the future. Oxytocin increases PCa (zeige FLVCR1 Proteine) growth and APPL1 (zeige APPL1 Proteine) expression.
Obese children had significantly higher irisin (zeige FNDC5 Proteine) and lower oxytocin levels than the healthy controls.
study found that rs6133010 in the OXT gene is associated with alcohol dependence in the northern Chinese Han population
OXT levels were lowest in anorexia nervosa, higher in healthy controls, and highest in obesity. There were positive associations between OXT and body mass index, total, visceral, and subcutaneous fat, and bone mineral density.
epigenetic modification of OXT is linked to several overt measures of sociability
Oxytocin prevents cartilage matrix destruction via regulating MMP1 (zeige MMP1 Proteine) and MMP13 (zeige MMP13 Proteine).
This is the first known study to show a significant association between callous unemotional traits in children and adolescents with extreme, persistent pervasive aggression and a polymorphism on the oxytocin receptor (zeige OXTR Proteine).
The presence of oxytocin in the mare (zeige C16orf35 Proteine) uterus was determined by radioimmunoassay of tissue extracts and uterine lavage fluid, and by immunohistochemistry.
There are two proteins encoded by this gene, oxytocin and neurophysin I. Oxytocin is posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.
, oxytocin-neurophysin 1
, oxytocin, prepro- (neurophysin I)
, oxytocin, prepropeptide
, oxytocin/neurophysin (Oxt) gene, complete gene, complete cds
, neurophysin I
, oxytocin-neurophysin I, preproprotein
, oxytocin-neurophysin I