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Gbetagamma signaling controls the polarization of zebrafish primordial germ cells by regulating Rac (zeige AKT1 ELISA Kits) activity.
We show that targeted knockdown of the G protein gng2 gene (Ggamma2) blocks the normal angiogenic process in developing zebrafish embryos. Moreover, loss of gng2 function inhibits the ability of VEGF to promote the angiogenic sprouting of blood vessels.
High GNG2 expression is associated with alcoholic hepatitis.
G-protein betagamma subunits are positive regulators of Kv7.4 (zeige KCNQ4 ELISA Kits) and native vascular Kv7 channel activity.
Alteration of gene expression profiling including GPR174 and GNG2 is associated with vasovagal syncope.
Data indicate that endogenous mTOR (zeige FRAP1 ELISA Kits) interacts with Gbetagamma.
increased protein expression level of GNG2 alone inhibits proliferation of malignant melanoma cells in vitro and in vivo
presence of Gng2 and Netrin-G2 immunoreactive elements in the insular cortex, but not in the putamen, suggests a possible common ontogeny of the claustrum and insula
Gbetagamma inhibits Epac (zeige RAPGEF3 ELISA Kits)-induced Ca 2 (zeige CA2 ELISA Kits)+ elevation in melanoma cells. Cross talk of Ca 2 (zeige CA2 ELISA Kits)+ signaling between Gbetagamma & Epac (zeige RAPGEF3 ELISA Kits) plays a major role in melanoma cell migration.
Data implicate the domain I-II linker region as an important contributor to voltage dependent Gbeta1/Ggamma2 modulation of Cav2.2 (zeige CACNA1B ELISA Kits) calcium channels.
Data show that activation of PLCbeta(2) by alpha(q) and beta1gamma2 differ from activation by Rac2 (zeige RAC2 ELISA Kits) and from each other.
Data show that G protein inhibition of N-type calcium channels is critically dependent on two separate but adjacent approximately 20-amino acid regions of the Gbeta (zeige SUCLG2 ELISA Kits) subunit, as examined with Gbetas 1 and 5 and Ggamma2.
determined the crystallographic structure of GRK2 in complex with G protein beta1gamma2 subunits
It was concluded that GIRK2 (zeige KCNJ6 ELISA Kits), through its dual responsiveness to G protein beta (zeige GNB3 ELISA Kits)-gamma and Na+, mediates a form of neuronal inhibition that is amplifiable in the setting of excess electrical activity.
signaling pathway by which G(i)-coupled receptor specifically induces Rac (zeige AKT1 ELISA Kits) and Cdc42 (zeige CDC42 ELISA Kits) activation through direct interaction of Gbetagamma with FLJ00018.
This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules.
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
, guanine nucleotide-binding protein gamma 2
, g gamma-I
, guanine nucleotide binding protein gamma 2
, guanine nucleotide-binding protein G(I)/G(O) gamma-2 subunit
, guanine nucleotide binding protein (G protein), gamma 2 subunit