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GNB4 is important for growth of breast cancer cells and a potential target for treatment
A novel missense GNB4 variant causes Charcot-Marie-Tooth disease F in two patients, who represent the first record of the disease in the Japanese population.
Suggest Gbeta4gamma1 as a modulator of M3 muscarinic receptor signaling.
Analysis of GNB4 in an additional 88 unrelated CMT individuals uncovered another de novo mutation.
Gbeta4 subunit is coexpressed in physiologically ON-type cone bipolar cells with Ggamma13 and Gbeta3 but is not present in OFF-type bipolar cells.
Gbeta4 is widely expressed, located on chromosome 3 with a genomic structure like Gbeta1 to Gbeta3, but different from Gbeta5
Intron-1 haplotypes of GNB4 may, thus, serve as predictive markers for progression and survival of patients suffering from bladder cancer.
Intron-1 haplotypes of GNB4 is associated with colorectal carcinoma.
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.
guanine nucleotide binding protein, beta 4
, guanine nucleotide-binding protein subunit beta-4
, transducin beta chain 4
, G protein beta-4 subunit
, G-protein beta 4 subunit
, guanine nucleotide binding protein (G protein), beta 4
, guanine nucleotide binding protein beta 4 subunit