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Bifurcation of the Tre1 G protein-coupled receptor signaling response via G protein-dependent and independent branches enables distinct spatiotemporal regulation of germ cell migration.
The scattershot allele results in an in-frame deletion of 8 amino acids at the junction of the third transmembrane domain and the second intracellular loop of Tre1 that dramatically impairs the function of this GPCR in germ cell migration.
plays an important role in regulation of germ cell migration, polarity , cell adhesion, and cadherin binding. (review)
Tre1 is a G protein-coupled receptor (zeige GPBAR1 Proteine) that directs transepithelial migration of Drosophila germ cells
Down-regulation of E-cadherin causes germ cell dispersal but is not sufficient for transepithelial migration in the absence of Tre1, suggesting a new mechanism for Tre1 GPCR function that links cell polarity, modulation of cell adhesion, and invasion.
CXCL12 (zeige CXCL12 Proteine)-CXCR7 axis accelerates migration and invasion of pancreatic cancer cells through mTOR (zeige FRAP1 Proteine) and Rho/ROCK pathways, and predicts poor prognosis of pancreatic cancer
The CXCR7/CXCL12 (zeige CXCL12 Proteine) axis is involved in lymph node and liver metastasis of gastric cancer.
Among 479 individuals affected with clear cell renal cell carcinoma (zeige MOK Proteine), only synonymous variants were found in COPS8 (zeige COPS8 Proteine) and one of the missense variants in ACKR3:c.892C>T, was observed in 4/479 individuals screened
Results show that CXCR7 is highly expressed in metastatic lymph node (MNL) of non-small cell lung neoplasm (NSCLC) and is associated with poor prognosis.
While the potencies of all proteins in ACKR3 Presto-Tango (zeige ARNT Proteine) assays were comparable, the efficacy of CXCL12 (zeige CXCL12 Proteine)(3-68) to activate ACKR3 was significantly reduced
CXCR7 mediates CD14 (zeige NDUFA2 Proteine)(+)CD16 (zeige CD16 Proteine)(+) monocyte transmigration across the blood brain barrier, and is a potential therapeutic target for neuro AIDS.
CXCR7 signaling could not be detected using impedance measurements. However, increasing levels of CXCR7 expression significantly reduced the CXCR4 (zeige CXCR4 Proteine)-mediated impedance readout, suggesting a regulatory role for CXCR7 on CXCR4 (zeige CXCR4 Proteine)-mediated signaling.
CXCR7 expression in gastric cancer tissues was significantly higher than that in adjacent non-cancer tissues and associated with tumor size, TNM (zeige ODZ1 Proteine) stage and lymph node metastasis. CXCR7 was identified as a novel promoter in gastric cancer initiation and progression.
the data identified the pivotal role of the receptor CXCR7 in pulmonary inflammation with a predominant effect on the pulmonary epithelium and polymorphonuclear neutrophils
SDF-1 (zeige CXCL12 Proteine)/CXCR7 plays a positive role in the proliferation and invasion of endometrial carcinoma cells.
the pivotal role of CXCR4 (zeige CXCR4 Proteine)- and CXCR7-inhibition in acute pulmonary inflammation, which depended on A2B (zeige ADORA2B Proteine)-receptor signaling, is reported.
endothelial CXCR7+ cells regulate CXCL12 (zeige CXCL12 Proteine) gradient direction by controlling concentrations near but not far from the vasculature.
High CXCR7 expression is associated with Prostate Cancer.
CXCR7 expression in adipose tissue macrophages is upregulated in obesity.
Elevated expression of CXCR7 enhances endothelial progenitor cell resistance to diabetes mellitus-induced oxidative damage.
expression of CXCR7 in normal and pathological nervous system suggests CXCR4 (zeige CXCR4 Proteine)-independent functions of SDF-1/CXCL12 (zeige CXCL12 Proteine) mediated through its interaction with CXCR7
confirm a pivotal role of the SDF-1 (zeige CXCL12 Proteine)/CXCR4 (zeige CXCR4 Proteine)/CXCR7 axis for chronic allograft vasculopathy development
our present study provided evidence that SDF-1 (zeige CXCL12 Proteine) mediated CSCs migration through CXCR4 (zeige CXCR4 Proteine) and CXCR7 via MEK (zeige MDK Proteine)/ERK (zeige EPHB2 Proteine) and PI3K/Akt (zeige AKT1 Proteine) pathway
Endothelial CXCR7 limits breast cancer metastasis at multiple steps in the metastatic cascade, advancing understanding of CXCL12 (zeige CXCL12 Proteine) pathways in tumor environments and informing ongoing drug development targeting CXCR7 in cancer.
This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas.
, G protein coupled receptor
, trapped in endoderm 1
, trapped in endoderm-1
, C-X-C chemokine receptor type 7
, G protein-coupled receptor
, G-protein coupled receptor 159
, G-protein coupled receptor RDC1 homolog
, chemokine (C-X-C motif) receptor 7
, chemokine orphan receptor 1
, RDC1-like G protein-coupled receptor
, G-protein coupled receptor RDC1