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this study shows an essential role of CXCR7, together with CXCR4, in the control of normal and malignant hematopoietic cell migration and homing induced by CXCL12.
Expression of CXCR7 associates with increased survival in CXCR4+ but not in CXCR4- DLBCL patients. CXCR7 overexpression in vitro is able to diminish DLBCL cell survival and increase their sensitivity to antitumor drugs.
Residues 2-6 of ACKR3 form an antiparallel beta-sheet with the beta1 strand (residues 25-29) of CXCL12.
These findings suggest that the manipulation of miR-539-5p/CXCR7 levels may have important therapeutic implications in choroidal neovascularization-associated diseases
CXCR7 is an oncogene in PCa that can promote aggressive progression of PCa through enhancing proliferation and migration of the tumor cells.
Study shows that overexpression of CXCR7 in different cellular populations of endometriosis microenvironment may play a role in the pathogenesis and represent a novel target for treatment.
CXCR7 silencing inhibits the migration and invasion of human tumor endothelial cells derived from hepatocellular carcinoma by suppressing STAT3.
Hetero-oligomerization of a1B/D-adrenergic receptor with the chemokine (C-X-C motif) receptor 4:atypical chemokine receptor 3 heteromeric complex is required for a1B/Dadrenergic receptor function
This work demonstrates distinct roles for the SDF-1/CXCR4 or CXCR7 network in human induced pluripotent stem cell-derived ventricular cardiomyocyte specification, maturation and function.
A role for CXCR7 in bladder cancer [review]
CXCR7-small hairpin RNA inhibits tumour invasion and metastasis.
Chemokine receptor CXCR7 may involve in the clinical glioblastoma (GBM) progression, and CXCR7 could be a valuable prognostic marker in the treatment of GBM.
Therefore, CXCR7 may be associated with peritoneal metastasis in gastric cancer.
CXCL12-CXCR7 axis accelerates migration and invasion of pancreatic cancer cells through mTOR and Rho/ROCK pathways, and predicts poor prognosis of pancreatic cancer
The CXCR7/CXCL12 axis is involved in lymph node and liver metastasis of gastric cancer.
Among 479 individuals affected with clear cell renal cell carcinoma, only synonymous variants were found in COPS8 and one of the missense variants in ACKR3:c.892C>T, was observed in 4/479 individuals screened
Results show that CXCR7 is highly expressed in metastatic lymph node (MNL) of non-small cell lung neoplasm (NSCLC) and is associated with poor prognosis.
While the potencies of all proteins in ACKR3 Presto-Tango assays were comparable, the efficacy of CXCL12(3-68) to activate ACKR3 was significantly reduced
CXCR7 mediates CD14(+)CD16(+) monocyte transmigration across the blood brain barrier, and is a potential therapeutic target for neuro AIDS.
CXCR7 signaling could not be detected using impedance measurements. However, increasing levels of CXCR7 expression significantly reduced the CXCR4-mediated impedance readout, suggesting a regulatory role for CXCR7 on CXCR4-mediated signaling.
CXCR7 gene overexpression promoted mesenchymal stem cell proliferation and migration, whereas suppressing CXCR7 had the opposite effect.
the Sdf-1 receptors - Cxcr4 and Cxcr7, as well as signaling pathways induced by these molecules in primary myoblasts, as well as various stem cells, were studied.
the pivotal role of CXCR4- and CXCR7-inhibition in acute pulmonary inflammation, which depended on A2B-receptor signaling, is reported.
endothelial CXCR7+ cells regulate CXCL12 gradient direction by controlling concentrations near but not far from the vasculature.
High CXCR7 expression is associated with Prostate Cancer.
the data identified the pivotal role of the receptor CXCR7 in pulmonary inflammation with a predominant effect on the pulmonary epithelium and polymorphonuclear neutrophils
CXCR7 expression in adipose tissue macrophages is upregulated in obesity.
Elevated expression of CXCR7 enhances endothelial progenitor cell resistance to diabetes mellitus-induced oxidative damage.
expression of CXCR7 in normal and pathological nervous system suggests CXCR4-independent functions of SDF-1/CXCL12 mediated through its interaction with CXCR7
confirm a pivotal role of the SDF-1/CXCR4/CXCR7 axis for chronic allograft vasculopathy development
our present study provided evidence that SDF-1 mediated CSCs migration through CXCR4 and CXCR7 via MEK/ERK and PI3K/Akt pathway
Endothelial CXCR7 limits breast cancer metastasis at multiple steps in the metastatic cascade, advancing understanding of CXCL12 pathways in tumor environments and informing ongoing drug development targeting CXCR7 in cancer.
Sata demonstrate that CXCR7 has a role in the positioning of hem and pallium-subpallium boundary-derived Cajal-Retzius (CR)cells, CXCL12 regulating CR cell subpial localization through the combined action of CXCR4 and CXCR7.
CXCR7 acts to prevent epithelial damage and ameliorate fibrosis after a single lung injury, repeated injury leads to suppression of CXCR7 expression and recruitment of VEGFR1 expressing macrophages, Wnt and Notch signaling, and enhanced fibrosis.
CXCR7 overexpression in MSCs reversed the inhibitory effect of high concentrations of SDF-1alpha.
Collectively, our data demonstrate that CXCR7 suppression modulates microglial chemotaxis to ameliorate EAE.
Both CXCR7 and Rac1 are required for extracellular signal-regulated kinases (ERK) 1/2 activation and subsequent NPC migration, indicating that CXCR7 could serve as a functional receptor in CXCL12-mediated NPC migration independent of CXCR4.
Blockade of CXCR7 suppressed MIF-mediated ERK- and zeta-chain-associated protein kinase (ZAP)-70 activation
The inhibitory effect of corticosterone on mesenchymal stromal cells (MSC) migration might be mediated via decreasing the expression of CXCR4 and CXCR7 in MSCs.
expression patterns of xSDF-1a, xCXCR4, and xCXCR7 during gastrulation; results suggest SDF-1 signaling supports migration of the mesendoderm cell cohort toward the animal pole and that activin/nodal signaling acts as a regulator of the expression of xSDF-1a and xCXCR4, but not xCXCR7
This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas.
C-X-C chemokine receptor type 7
, G protein-coupled receptor
, G-protein coupled receptor 159
, G-protein coupled receptor RDC1 homolog
, chemokine (C-X-C motif) receptor 7
, chemokine orphan receptor 1
, G protein coupled receptor
, G-protein coupled receptor RDC1
, RDC1-like G protein-coupled receptor
, RDC1 like protein
, atypical chemokine receptor 3 L homeolog
, atypical chemokine receptor 3