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Human CAMK1 Protein expressed in Wheat germ - ABIN1347913
Mallampalli, Kaercher, Snavely, Pulijala, Chen, Coon, Zhao, Agassandian: Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I. in Cellular signalling 2013
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Characterization of extensive electrostatic and hydrophobic contacts between calmodulin (CaM) and the CaM-binding domain peptide allows a detailed analysis of the structural basis of the kinase activation process.
The mRNA expressions of PPP3CB (zeige PPP3CB Proteine) and MEF2C (zeige MEF2C Proteine) were significantly up-regulated, and CAMK1 and PPP3R1 (zeige PPP3R1 Proteine) were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB (zeige PPP3CB Proteine), MEF2C (zeige MEF2C Proteine) and PLCE1 (zeige PLCE1 Proteine) compared to aortic valve disease patients
Barettin has inhibitory activity against two protein kinases related to inflammation, namely the receptor-interacting serine/threonine kinase 2 (RIPK2 (zeige RIPK2 Proteine)) and calcium/calmodulin-dependent protein kinase 1alpha (CAMK1alpha).
CAMK1 functional regulation subnetwork in hepatocellular carcinoma
this study suggests that the tightly linked regulatory loop comprised of the SIK2 (zeige SIK2 Proteine)-PP2A (zeige PPP2R4 Proteine) and CaMKI and PME-1 (zeige PPME1 Proteine) networks may function in fine-tuning cell proliferation and stress response.
It is one of Ca(2 (zeige CA2 Proteine)+)-sensing proteins and substantial age- and Alzheimer disease(AD)-related alterations in Ca(2 (zeige CA2 Proteine)+)-sensing proteins most likely contribute to selective vulnerability of basal forebrain cholinergic neurons to degeneration in AD.
Fbxl12 (zeige FBXL12 Proteine)-induced CaMKI degradation attenuates p27 (zeige PAK2 Proteine) phosphorylation at these sites in early G1 and iii) activation of CaMKI during G1 transition followed by p27 (zeige PAK2 Proteine) phosphorylation appears to be upstream to other p27 (zeige PAK2 Proteine) phosphorylation events
structures of three CaMKIalpha truncates in apo (zeige C9orf3 Proteine) form and in complexes with ATP
CaMKI was significantly upregulated in adrenal adenomas.
variants in doublecortin (zeige DCX Proteine)- and calmodulin kinase like 1, a gene up-regulated by BDNF (zeige BDNF Proteine), have roles in memory and general cognitive abilities
CaMKI is involved in angiotensin II and K(+) stimulation of CYP11B2 (zeige CYP11B2 Proteine) transcription and the capacity of the adrenal to produce aldosterone
report that Parvalbumin (zeige PVALB Proteine) positive interneurons employ a novel CaMK (zeige CAMK2G Proteine)-dependent pathway to trigger CREB (zeige CREB1 Proteine) phosphorylation and gene expression.
the CaMKK (zeige CAMKK2 Proteine)-CaMKIalpha cascade is required for the axonal growth effect of Wnt5a (zeige WNT5A Proteine) during neuronal polarization.
CaMKIalpha regulates AMP (zeige TMPRSS5 Proteine) kinase-dependent, TORC-1 (zeige CRTC1 Proteine)-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation.
CaMKI vies with CRM1/exportin 1 (zeige XPO1 Proteine) for access to a nuclear export signal, and assembly of a CaMKI-14-3-3 zeta (zeige YWHAZ Proteine)-CCTalpha (zeige PCYT1A Proteine) complex is a key effector mechanism that drives nuclear CCTalpha (zeige PCYT1A Proteine) translocation.
CaMKIalpha signaling is integral to the Mvarphi responding to LPS (zeige TLR4 Proteine) and may also be operant in vivo in regulating the inflammation and organ dysfunction consequent to sepsis.
Inflammatory acidic environments activate Trpv1 (zeige TRPV1 Proteine), leading to an up-regulation of CGRP (zeige CALCA Proteine) expression via CaMK (zeige CAMK2G Proteine)-CREB (zeige CREB1 Proteine) cascade, a series of events that may be associated with inflammatory pain.
calcium/calmodulin-dependent protein kinase I and IV in vitro substrates reveals distinct catalytic preferences
ERK (zeige EPHB2 Proteine) activation and neurite outgrowth in response to depolarization are mediated by CaMKK (zeige CAMKK2 Proteine) activation of CaMKI
Full-length cDNA encoded am amino acid sequence similar to that of calmodulin kinase I.
Interaction of MARK2 (zeige MARK2 Proteine) with CaMKI results in a novel, calcium-dependent pathway that plays an important role in neuronal differentiation.
Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.
, calmodulin-dependent kinase
, caM kinase I alpha
, calcium/calmodulin-dependent protein kinase type 1
, G alpha interacting protein
, regulator of G-protein signalling 19
, Ca++/calmodulin-dependent protein kinase 2 delta subunit
, Ca++/calmodulin-dependent protein kinase II delta subunit
, Ca++/calmodulin-dependent protein kinase II, delta subunit
, caM kinase II subunit delta
, caM-kinase II delta chain
, caMK-II subunit delta
, calcium/calmodulin-dependent protein kinase (CaM kinase) II delta
, calcium/calmodulin-dependent protein kinase type II delta chain
, calcium/calmodulin-dependent protein kinase type II subunit delta