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Human ATF3 Protein expressed in Wheat germ - ABIN1345929
Wang, Brennan, Gutierrez, Wang, Wang, Yang: SUMOylation of ATF3 alters its transcriptional activity on regulation of TP53 gene. in Journal of cellular biochemistry 2013
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Data show that Atf3 was detected in retinal ganglion cell axons in both the nerve fiber layer and the optic nerve on the injured side.
Data show that ATF3 may be an important mediator of optic nerve regeneration-promoting gene expression in fish, a role which merits further investigation.
ATF3 plays a significant role in regulating human endometrial receptivity and embryo attachment in vitro via up-regulation of leukemia inhibitory factor (zeige LIF Proteine).
Upregulation of ATF3 in lung cancer promotes cell proliferation, migration, and invasion, and may represent a novel therapeutic target for lung cancer
ATF3 is a negative regulator of inflammation in human fetal membranes; in primary amnion cells, ATF3 expression is induced by IL-1beta (zeige IL1B Proteine) and fsl-1 (zeige FSTL1 Proteine), and ATF3 silencing further exacerbates the inflammatory response when stimulated with these factors. Subsequently, ATF3 expression is decreased in fetal membranes after term labour and with preterm chorioamnionitis, conditions closely associated with inflammation and infection.
Altering TR4 (zeige NR2C2 Proteine)-ATF3 signaling increases the efficacy of cisplatin to suppress hepatocellular carcinoma growth/progression.
ATF3 may be a potential early diagnostic biomarker for silicosis and ATF3 acts as a repressor in inflammatory responses induced by silica
The analysis showed higher urinary NGAL (zeige LCN2 Proteine) and urinary ATF3 in patients with sepsis-AKI in comparison with patients with sepsis-non-AKI and healthy volunteers.
ATF3 mRNA and protein expression was significantly reduced in preterm Preeclamptic placentas. Therefore, reduced ATF3 may be centrally involved in the pathology of Preeclampsia.
Data suggest that suppression of nonsense-mediated RNA decay due to persistent DNA damage (from exposure to either mutagens, gamma rays, or oxidative stress) requires the activity of p38alpha (zeige MAPK14 Proteine) MAPK (zeige MAPK1 Proteine) (MAPK14 (zeige MAPK14 Proteine), mitogen-activated protein kinase 14 (zeige MAPK14 Proteine), MAP kinase p38 alpha (zeige MAPK14 Proteine)); mRNA of ATF3 (activating transcription factor 3) is stabilized by persistent DNA damage in a p38alpha (zeige MAPK14 Proteine) MAPK (zeige MAPK1 Proteine)-dependent manner.
The microvascular injury phenotypes observed in vitro and in vivo were similar. ATF3 plays an important role in mediating brain microvascular responses to acute and chronic lipotoxic injury and may be an important preventative and therapeutic target for endothelial dysfunction in vascular cognitive impairment .
we have identified ATF3 as an important regulator of cisplatin cytotoxicity and that ATF3 inducers in combination with platins are a potential novel therapeutic approach for NSCLC.
ATF3 inhibit the expression and release of TNF-alpha (zeige TNF Proteine), IL-1beta (zeige IL1B Proteine), IL-6 (zeige IL6 Proteine), and IL-18 (zeige IL18 Proteine) induced by Mycoplasma pneumonia in vitro and in vivo, which is associated with its negative regulation of Egr-1 (zeige EGR1 Proteine)/Fyn (zeige FYN Proteine) signaling pathway.
The different anti-inflammatory mechanisms of the ApoA-I (zeige APOA1 Proteine) cysteine mutants might be associated with the regulation of ATF3 level.
ATF3 is a new co-factor of c-Fos and NFATc1 (zeige NFATC1 Proteine) to activate osteoclast differentiation and activity.
This study shows, for the first time, that alpha-lactalbumin (zeige LALBA Proteine) isolated in a rare 28kDa dimeric form induces cell death, while 14kDa (zeige SRP14 Proteine) monomeric alpha-lactalbumin (zeige LALBA Proteine) is inactive.
Results show a pro-regenerative ATF3 function during PNS nerve regeneration involving transcriptional activation of a neuropeptide-encoding regeneration-associated gene cluster.
Results reveal a critical role for ATF3 as a key regulator of the acinar cell transcriptional response during injury and may provide a link between chronic pancreatitis and PDAC.
The lung injury score and mortality were higher in ATF3 knock-out mice treated with Pseudomonas aeruginosa. Moreover, ATF3 was demonstrated to bind to lipopolysaccharide binding protein (zeige LBP Proteine). These findings suggest ATF3 protects mice against acute lung injury induced by Pseudomonas aeruginosa partly due to the binding to lipopolysaccharide binding protein (zeige LBP Proteine).
ATF3-KO mice escape from PE-dependent maladaptive cardiac remodeling by suppressing the IFNgamma-CXCL10 (zeige CXCL10 Proteine)-CXCR3 (zeige CXCR3 Proteine) axis at multiple levels.
ATF3 has a protective role in dampening the high fat-induced cardiac remodeling processes.
ATF3 protects against LPS (zeige TLR4 Proteine)-induced acute lung injury by inhibiting TL1A (zeige TNFSF15 Proteine) expression.
ATF3 appears to affect gonadotropin-stimulated progesterone secretion at a step or steps downstream of PKA signaling and before cholesterol conversion to progesterone.
ATF3 induction by acute hypoxia is mediated by nitric oxide and the JNK (zeige MAPK8 Proteine) pathway in endothelial cells
Data indicate increasing expression for CREB (zeige CREB1 Proteine), ATF1 (zeige AFT1 Proteine), and ATF3 during gastrulation.
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes.
cyclic AMP-dependent transcription factor ATF-3
, activating transcription factor 3
, cAMP-dependent transcription factor ATF-3
, transcription factor LRG-21
, liver regeneration factor 1