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Human ATF3 Protein expressed in Wheat germ - ABIN1345929
Wang, Brennan, Gutierrez, Wang, Wang, Yang: SUMOylation of ATF3 alters its transcriptional activity on regulation of TP53 gene. in Journal of cellular biochemistry 2013
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Data show that Atf3 was detected in retinal ganglion cell axons in both the nerve fiber layer and the optic nerve on the injured side.
Data show that ATF3 may be an important mediator of optic nerve regeneration-promoting gene expression in fish, a role which merits further investigation.
electrophilic properties of itaconate and derivatives regulate the IkappaBzeta (zeige NFKBIZ Proteine)-ATF3 inflammatory axis; results demonstrate that targeting the DI-IkappaBzeta (zeige NFKBIZ Proteine) regulatory axis could be an important new strategy for the treatment of IL-17 (zeige IL17A Proteine)-IkappaBzeta (zeige NFKBIZ Proteine)-mediated autoimmune diseases
High ATF3 expression is associated with breast cancer.
ATF3 and EGR1 (zeige EGR1 Proteine) are involved in the beginning of inflammatory processes. Whether these two transcription factors act as tumour suppressors or promoters is context dependent and warrants analysis in further studies
ATF3 and PRAP1 (zeige PRAP1 Proteine) play important roles in cisplatin-induced DNA damage repair process.
Data show that amino acid limitation (amino acid response, AAR) activation of activating transcription factor 3 (ATF3) transcription is transient relative to activation by the unfolded protein response (UPR).
In patients with NAFLD and/or T2D, a significant positive correlation was observed between hepatic ATF3 expression and surrogate markers of T2D, mitochondrial dysfunction, and macrophage infiltration.
our results suggest that ATF3 promotes the invasion and proliferation of CRC (zeige CALR Proteine) cells, at least in part, via the regulation of CEACAM1 (zeige CEACAM1 Proteine)-mediated EMT (zeige ITK Proteine).
ATF3 is involved in promoting particulate matter-induced pulmonary inflammation.
Negative pressure wound therapy exerts an anti-inflammatory effect, possibly through the suppression of proinflammatory enzymes and cytokines resulting from Ik B-alpha inhibition and ATF-3 activation, which may prevent the activation of the NF-kappaB (zeige NFKB1 Proteine) pathway in human diabetic foot wounds.
ATF3 plays a significant role in regulating human endometrial receptivity and embryo attachment in vitro via up-regulation of leukemia inhibitory factor (zeige LIF Proteine).
ATF3 in the host cells regulated a chemotherapeutic agent to immune modulation and cancer metastasis.
this study reveals a novel mechanism of naringenin through AMPK (zeige PRKAA1 Proteine)-ATF3-dependent negative regulation of the LPS/TLR4 (zeige TLR4 Proteine) signalling pathway, which thereby confers protection against murine endotoxaemia.
Conditional deletion of ATF3 in osteoclast precursors protects RANKL (zeige TNFSF11 Proteine)-induced osteoclast activation and bone loss.
Data (including data from studies using mutant, transgenic, and knockout mice) suggest that gene targets of leptin/leptin (zeige LEP Proteine)-receptor (zeige LEPR Proteine) (Lep (zeige LEP Proteine)/Lepr (zeige LEPR Proteine)) signaling in hypothalamic neurons regulate energy metabolism; Lep (zeige LEP Proteine)/Lepr (zeige LEPR Proteine) signaling appears to up-regulate expression of Atf3 (activating transcription factor-3) in hypothalamic neurons.
ATF3 promotes macrophage migration and reverses M1polarized macrophages to the M2 phenotype by upregulation of TNC via the Wnt/betacatenin signaling pathway.
Microglia make contact through unknown neuronal signals regulated by ATF3 in hypoglossal nucleus.
ATF3 inhibit the expression and release of TNF-alpha (zeige TNF Proteine), IL-1beta (zeige IL1B Proteine), IL-6 (zeige IL6 Proteine), and IL-18 (zeige IL18 Proteine) induced by Mycoplasma pneumonia in vitro and in vivo, which is associated with its negative regulation of Egr-1 (zeige EGR1 Proteine)/Fyn (zeige FYN Proteine) signaling pathway.
The different anti-inflammatory mechanisms of the ApoA-I (zeige APOA1 Proteine) cysteine mutants might be associated with the regulation of ATF3 level.
ATF3 appears to affect gonadotropin-stimulated progesterone secretion at a step or steps downstream of PKA signaling and before cholesterol conversion to progesterone.
ATF3 induction by acute hypoxia is mediated by nitric oxide and the JNK (zeige MAPK8 Proteine) pathway in endothelial cells
Data indicate increasing expression for CREB (zeige CREB1 Proteine), ATF1 (zeige AFT1 Proteine), and ATF3 during gastrulation.
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes.
cyclic AMP-dependent transcription factor ATF-3
, activating transcription factor 3
, cAMP-dependent transcription factor ATF-3
, transcription factor LRG-21
, liver regeneration factor 1