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anti-Mouse (Murine) PEX5 Antikörper:
anti-Rat (Rattus) PEX5 Antikörper:
anti-Human PEX5 Antikörper:
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Mouse (Murine) Monoclonal PEX5 Primary Antibody für IF, WB - ABIN968605
Baes, Gressens, Baumgart, Carmeliet, Casteels, Fransen, Evrard, Fahimi, Declercq, Collen, van Veldhoven, Mannaerts: A mouse model for Zellweger syndrome. in Nature genetics 1997
Show all 4 Pubmed References
Human Polyclonal PEX5 Primary Antibody für ELISA, WB - ABIN4344980
Alencastre, Rodrigues, Grou, Fransen, Sá-Miranda, Azevedo: Mapping the cargo protein membrane translocation step into the PEX5 cycling pathway. in The Journal of biological chemistry 2009
monoubiquitination of the N-terminal cysteine of peroxisome-associated PEX5 not only functions to recycle the peroxin back to the cytosol, but also serves as a quality control mechanism to eliminate peroxisomes with a defective protein import machinery
Demyelination in cerebellum and brain stem preceded major myelin loss in corpus callosum of Pex5 deficient mice.
interaction of PEX5 with catalase (zeige CAT Antikörper) and PEX14 (zeige PEX14 Antikörper)
Peroxisomes were selectively reconstituted in brain or liver of Pex5 knock-out mice, a model for Zellweger syndrome (zeige PEX1 Antikörper), by tissue-selective overexpression of Pex5p. We found that both rescue strains exhibited a correction of the neuronal migration defect
these findings lend credit to the idea that inefficient catalase (zeige CAT Antikörper) import, when coupled with the role of PEX5 as a redox-regulated import receptor, constitutes a cellular defense mechanism to combat oxidative insults of extra-peroxisomal origin.
TRIM37 (zeige TRIM37 Antikörper)-mediated ubiquitylation stabilizes PEX5 and promotes peroxisomal matrix protein import, suggesting that mulibrey nanism is a new peroxisomal biogenesis disorder.
Data suggest that soluble/cytosolic PEX5 interacts with PEX14 (zeige PEX14 Antikörper)/PEX13 (zeige PEX13 Antikörper) complex, a model for the docking/translocation module (DTM) of the peroxisomal matrix protein translocon; PEX14 (zeige PEX14 Antikörper)/PEX13 (zeige PEX13 Antikörper) complex appears to function in peroxisomal membrane as large cavity into which cytosolic PEX5 can enter to release its cargo. (PEX (zeige PHEX Antikörper) = peroxisomal biogenesis factor)
data reveal subpopulations of peroxisomes showing only weak colocalization between PEX14 (zeige PEX14 Antikörper) and PEX5 or PEX11 but at the same time a clear compartmentalized organization. This compartmentalization, which was less evident in cases of strong colocalization, indicates dynamic protein reorganization linked to changes occurring in the peroxisomes.
our data suggest that insertion of the trimeric PEX5-PEX7 (zeige PEX7 Antikörper)-PTS2 protein complex into the DTM is probably accompanied by conformational alterations in PEX5 to allow release of the PTS2 protein into the organelle matrix
Our data suggest that the functional polymorphism rs3814058C>T in 3'-UTR (zeige UTS2R Antikörper) of PXR (zeige NR1I2 Antikörper) may be a functional biomarker to predict risk of colorectal cancer
PEX5 encodes two isoforms, PEX5L (zeige PEX5L Antikörper) & PEX5S, & a homozygous frame shift mutation c.722dupA (p.Val242Glyfs( *)33), located in the PEX5L (zeige PEX5L Antikörper)-specific exon 9, results in loss of PEX5L (zeige PEX5L Antikörper) only. Loss of PEX5L (zeige PEX5L Antikörper) results in deficient import of PTS2-tagged proteins
bulky side chain within the recognition motif, which blocks contraction of the PEX5 binding cavity
Data show that ataxia-telangiectasia mutated (ATM (zeige ATM Antikörper)) phosphorylates peroxisomal biogenesis factor 5 (PEX5) at serine 141 in response to reactive oxygen species.
ubiquitination of peroxisome-targeting signal type 1 (PTS1) receptor Pex5p regulating PTS1 protein import
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.
peroxisome biogenesis factor 5
, PTS1 receptor
, peroxin 5
, peroxisomal C-terminal targeting signal import receptor
, peroxisomal targeting signal 1 receptor
, peroxisome receptor 1
, peroxisomal targeting signal 1 (SKL type) receptor
, peroxisomal targeting signal import receptor
, peroxisomal targeting signal receptor 1
, Peroxisomal C-terminal targeting signal import receptor
, Peroxisome receptor 1