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AMACR expression was studied in normal mucosa of the colon, adenomas with different degrees of dysplasia, colonic carcinomas, lymph nodes and liver metastases of colonic carcinomas. Expression was nearly absent in samples of normal mucosa, increased in both adenomas and carcinomas, decreased in lymph node metastases but was significantly increased in liver metastases.
IMP3 (zeige IGF2BP3 Proteine) has a similar specificity, but a better sensitivity, intensity, and extent of reactivity in comparison with AMACR, and may be used as an alternative to AMACR, in support of the diagnosis of BE-dysplasia and EAC (zeige CYLD Proteine)
As an adjunct to biopsy, AMACR and HMWCK have value for resolving diagnostically challenging cases
Single nucleotide polymorphism in AMACR gene is associated with schizophrenia risk loci with potential implications for neurocognitive performance.
Results show that AMACR expression is significantly high in patients with prostate cancer.
High AMACR expression is associated with prostate cancer.
AMACR staining was positively expressed in 86 of the prostate carcinoma cases and completely absent in remaining 12.
Data show a significant association between Alpha-methylacyl-CoA racemase (AMACR) and ERG (zeige ERG Proteine) protein with prognostic implication in prostate cancer.
AMACR is expressed in most of the chordomas but only in a minority of chondrosarcomas. AMACR may serve as IHC marker of chordoma with differentiating ability comparable to that of beta-catenin (zeige CTNNB1 Proteine).
AMACR transcripts were detected in all radical prostatectomy(RP)-prostate cancer and RP-Benign samples but not in non-cancerous cystoprostatectomy samples, which suggest a global increase of AMACR expression in cancerous prostates.
observed a disease-dependent elevation of AMACR expression in monocytes and T cells from blood, draining lymph nodes and spleen of autoimmune experimental encephalomyelitis mice during preclinical phase; in vitro analysis revealed proliferation of T cells was inhibited in AMACR KO mice, but T-cell polarization was switched toward a pathogenic state
Phytol causes primary failure in liver leading to death of Amacr-/- mice thus emphasizing the indispensable role of Amacr in detoxification of alpha-methyl-branched fatty acids.
AMACR has a role in the synthesis of bile acids.
Metabolic adaptation allows Amacr-deficient mice to remain symptom-free despite low levels of mature bile acids.
This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene.
, Alpha-methylacyl-CoA racemase
, alpha-methylacyl-CoA racemase-like
, amacr protein
, 2-methylacyl-CoA racemase
, 2-arylpropionyl-CoA epimerase
, alpha-methylacyl-Coenzyme A racemase