Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Data show that knockdown of thymidylate synthase (TS) significantly impairs TH17 and TH1 (zeige HAND1 Proteine) cell differentiation.
Possible interaction routes between hydrophobic residues of the mouse thymidylate synthase protein N-terminal segment and the active site are also discussed
SHMT1 (zeige SHMT1 Proteine) and TYMS localization to the nucleus is essential to prevent uracil accumulation in DNA
Synergistic activation of the TATA-less thymidylate synthase promoter by the Ets transcription factor (zeige ELF2 Proteine) GABP and Sp1 (zeige SP1 Proteine).
downregulation of expression results in block of cell cycle expression when influenced by Fe65 (zeige APBB1 Proteine)
posttranslationally-modified thymidylate synthase is associated with cell resistance to 5-fluoro-dUrd
Dihydrofolate reductase (zeige DHFR Proteine) and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells.
High expression level of TYMS is associated with neuroendocrine lung tumors.
This study finds that measurement of tumor levels of thymidylate synthase is not helpful in assigning specific adjuvant treatment for colorectal cancer. It also highlights the importance of using prospective analyses within treatment clinical trials as the optimal method of determining biomarker utility.
Study shows that the TYMS TSER 3R allele increases the risk of thymic lymphoid hyperplasia in AChR+ Myasthenia Gravis (MG) patients and that the 3R allele in the promoter enhancer region results in increased protein production required for the synthesis of DNA precursors.
polymorphisms of TS 5'-UTR 2R (double repeats)/3R (triple repeats) of a 28-bp sequence (11 articles) and 3'-UTR del6/ins6 (seven articles) were not significantly associated with increased risk of gastric cancer.
There was significantly higher thymidylate synthase (TS) expression in non-small cell lung cancer (NSCLC) tumor tissue comparing to normal lung tissue.
Crystal structure of the active form of native human thymidylate synthase in the absence of bound substrates has been reported.
The Thymidylate synthase (TS)-ZEB1 association was confirmed in clinical specimens from lung tumours and in a genetic mouse model of pancreatic cancer with ZEB1 deletion. Interestingly, TS itself appeared to have a regulatory role in epithelial-to-mesenchymal in cancer cells, as TS knockdown could directly reduce the EMT (zeige ITK Proteine) phenotype, the migratory ability of cells, the expression of stem-like markers, and chemoresistance.
Study of genetic risk of prevalent hrHPV infections in Nigerian women found significant associations with SNPs on ribosomal protein gene S19 (RPS19 (zeige RPS19 Proteine)) and Thymidylate Synthase gene (TYMS), in an allelic model. This risk remained significant, after adjusting for age, body mass index, smoking, age at menarche, age at sexual debut, lifetime total number of sexual partners and the total number of pregnancies.
High thymidylate synthetase expression is associated with chemoresistance in glioblastoma multiforme.
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
, thymidylate synthase
, thymidylate synthetase
, thymidylate synthase-like