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these results indicated that TOP2 gene was involved in candidal pathogenicity, and the major reasons for the comparatively high virulence of null mutants were the higher capacity to produce hyphae and the increased phospholipase and proteinase activities
These results demonstrate a close relationship between the TOP2 gene and drug susceptibility in C. albicans.
The Top2-Mus101 interaction is important for maintaining the fidelity of chromosome segregation during mitosis.
our results suggest that the previously observed discrepancies in the chromosomal phenotypes elicited by Topo II downregulation in vertebrates might depend on slight differences in Topo II concentration and/or activity
These data suggest both that Topoisomerase II is involved in the resolution of heterochromatic DNA entanglements during meiosis I and that these entanglements must be resolved in order to complete meiosis.
Topo II is required to prevent Mod(mdg4)2.2 degradation and, consequently, to stabilize Su(Hw) insulator-mediated chromatin organization
Topo II does have some role in mitotic chromatin condensation
Results suggest that displacement of the heterochromatin proteins D1, HP1 and topoisomerase II from satellite III result in stochastic chromatin opening and desilencing of the nearby white gene in white-mottled flies.
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
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