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TP53 (zeige TP53 Proteine) mutant cancer cells had elevation of ribonucleotide reductase subunit 1 (RRM1 (zeige RRM1 Proteine)) and 2 (RRM2), which was reduced by inhibition of mTORC1.
Results indicate CREB1 (zeige CREB1 Proteine) as a critical transcription factor of RRM2 which promotes tumor aggressiveness, and imply a significant correlation between CREB1 (zeige CREB1 Proteine) and RRM2 in CRC (zeige CALR Proteine) specimens.
These findings suggest that the identified APLP2 (zeige APLP2 Proteine), RRM2, and PRC1 (zeige PRC1 Proteine) signature could be useful for distinguishing between benign (follicular adenoma) and malignant (follicular carcionma and follicular variant of papillary carcinoma) tumors of the thyroid follicular epithelium.
Data show that inhibition of sphingosine kinase-2 (zeige SPHK2 Proteine) by ABC294640 is synergistically cytotoxic with gemcitabine toward three pancreatic cancer cell lines, resulting in decreased expression of both ribonucleotide reductase regulatory subunit M2 (RRM2) and c-MYC (zeige MYC Proteine) protein (Myc (zeige MYC Proteine)) in all three cell lines.
Based on the results of clinical trials, we conclude that Ribonucleotide reductase (RR) enzymes (RR1 (zeige RRM1 Proteine) and RR2)inhibitors are viable treatment options, either as a monotherapy or as a combination in cancer chemotherapy. With the recent advances made in cancer biology, further development of RR inhibitors with improved efficacy and reduced toxicity is possible for treatment of variety of cancers.
Here we designed UC-rich and CU-rich 10-nt sequences for engagement of both RRM2 and RRM3 and demonstrated that the TIA-1 (zeige TIA1 Proteine) RRM23 construct preferentially binds the UC-rich RNA ligand. Together our data support a specific mode of TIA-1 (zeige TIA1 Proteine) RRM23 interaction with target oligonucleotides consistent with the role of TIA-1 (zeige TIA1 Proteine) in binding RNA to regulate gene expression
These data suggest that VASH2 (zeige VASH2 Proteine) reduces the chemosensitivity to gemcitabine in pancreatic cancer cells via JUN (zeige JUN Proteine)-dependent transactivation of RRM2.
HPV31 regulates RRM2 levels through expression of E7 and activation of the ATR (zeige ANTXR1 Proteine)-Chk1 (zeige CHEK1 Proteine)-E2F1 (zeige E2F1 Proteine) DNA damage response, which is essential to combat replication stress upon entry into S-phase.
To the best of our knowledge, this is the first study that investigated the relationship of RRM1 and RRM2 gene polymorphisms and Coronary artery disease (CAD).
The SCYL1- BP1 (zeige GORAB Proteine) affects the cell cycle through increasing steady state levels of Cyclin F (zeige CCNF Proteine) and RRM2 proteins, thus constituting a dual regulatory circuit.
This work reveals that binding of RRM1 (zeige RRM1 Proteine) to RRM2 is essential for mammalian cells and provides the first loss-of-function model of the ribonucleotide reductase complex for genetic studies.
mice carrying extra alleles of the RNR regulatory subunit RRM2 (Rrm2(TG)) present supraphysiological RNR activity and reduced chromosomal breakage at fragile sites
analysis of transgenic overexpression of ribonucleotide reductase Rrm1 (zeige RRM1 Proteine) and Rrm2 improves cardiac performance
Cinobufotalin significantly inhibits the growth of the xenografts of endometrial carcinoma Ishikawa in nude mice by inhibiting RRM2 expression.
Data suggest that RRM2 may be an important effector of progesterone signaling to induce cell proliferation and decidualization in uterus.
illegitimate recombination initiated by c-Myc (zeige MYC Proteine)
Adrenergic stimulation of brown adipocytes elevates ribonucleotide reductase subunit R2 in the proliferative stage of adipocyte development; mediating pathways include cAMP/PKA cascades, Src (zeige SRC Proteine) and Erk (zeige EPHB2 Proteine) Map Kinases.
S Phase-specific transcription of the mouse ribonucleotide reductase R2 gene requires both a proximal repressive E2F (zeige E2F1 Proteine)-binding site and an upstream promoter activating region
Chk1 is required for DNA replication at least through regulating RNR2 gene transcription.
results indicate that the affinity of the RNR R2 proteins for binding metals is determined by the nature of one specific residue in the vicinity of the dimetal site, namely the one that carries the tyrosyl radical in class Ia and Ib R2 proteins
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.
ribonucleoside-diphosphate reductase subunit M2
, ribonucleotide reductase M2 polypeptide
, ribonucleotide reductase small chain
, ribonucleotide reductase small subunit
, ribonucleoside-diphosphate reductase M2 chain
, Ribonucleotide reductase 2
, reductase M2 polypeptide variant 1
, reductase M2 polypeptide variant 2
, reductase M2 polypeptide variant 3a
, reductase M2 polypeptide variant 3b
, reductase M2 polypeptide variant 3c
, reductase M2 polypeptide variant 3d
, ribonucleotide reductase protein r2 class I