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Findings provide the first direct evidence for the function of alternative form of RPA in human DNA metabolism and support a model for aRPA functioning in chromosome maintenance functions in nonproliferating cells.
Hyperphosphorylated replication protein A (zeige GPR153 Proteine) is preferentially localized to double-stranded break repair and the DNA damage checkpoint complexes in response to DNA damage.
This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.
RF-A protein 4
, RP-A p30
, replication factor A protein 4
, replication protein A 30 kDa subunit
, replication protein A complex 34 kd subunit homolog Rpa4
, replication protein A4, 34kDa